Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

Reduction of Human Intraocular Pressure with Intravenous Mannitol

Reduction of Human Intraocular Pressure with Intravenous Mannitol Abstract The reduction of intraocular pressure when this is acutely raised and prior to surgery is often essential. Osmotically acting urea has been used for this purpose during the past 2 years.1-11 It is desirable that such therapy should be both effective and free from harmful and annoying side-effects to the patient. This has not been entirely the case with urea which can produce uncontrollable diuresis, headaches analogous to postlumbar puncture headaches, necrosis of soft tissue, nausea and vomiting, arm pain, confusion, hyperthermia, a shock-like state,2 hypertension in labile hypertensives, thirst,7 and increase in blood volume with pulmonary edema.4 Hypertonic mannitol has been used to reduce intracranial pressures in animals and humans and would appear to be safe and effective for this purpose.13 The use of mannitol to reduce intraocular pressure was suggested to one of us by Dr. Shaffer on a recent visit to San References 1. Tarter, R. C., and Linn, J. G.: A Clinical Study of the Use of Intravenous Urea in Glaucoma , Amer. J. Ophthal. 52:323, 1961. 2. Crews, S. J., and Davidson, S. I.: Intravenous Urea Therapy in Glaucoma , Brit. J. Ophthal. 45: 769, 1961.Crossref 3. Fink, A. J.; Binkhorst, R. D., and Funahashi, R.: Intravenous Urea and Angle Closure Glaucoma , Amer. J. Ophthal. 52:872, 1961. 4. Ackerman, A. L.: The Action of Urea in Acute Glaucoma , Amer. J. Ophthal. 52:875, 1961. 5. Hill, K.; Whitney, J. B., and Trotter, R. R.: Intravenous Hypertonic Urea in the Management of Acute Angle-Closure Glaucoma , Arch. Ophthal. 65:497, 1961.Crossref 6. Davis, M. D.; Duehr, P. A., and Javid, M.: The Clinical Use of Urea for Reduction of Intraocular Pressure , Arch. Ophthal. 65:526, 1961.Crossref 7. Klöti, R.: The Indications for Intravenous Urea in Ophthalmology , Ophthalmologica 141:378, 1961.Crossref 8. Galin, M. A.; Nano, H. D., and Davidson, R. A.: Aqueous and Blood Urea Nitrogen Levels After Intravenous Urea Administration , Arch. Ophthal. 65:805, 1961.Crossref 9. Galin, M. A., and Baras, I.: Intravenous Urea in Retinal Detachment Surgery , Arch. Ophthal. 65:652, 1961.Crossref 10. Drance, S. M.: Unpublished data. 11. Klöti, R.: The Use of Urea in Glaucoma Therapy, Abstract , Amer. J. Ophthal. 51:355, 1961. 12. Weiss, D. I.; Shaffer, R. N., and Wise, B. L.: Mannitol Infusion to Reduce Intraocular Pressure , Arch. Ophthal. 68:341, 1962.Crossref 13. Wise, B. L., and Chater, N.: Effect of Mannitol on Cerebrospinal Fluid Pressure , Arch. Neurol. 4:200, 1961.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Ophthalmology American Medical Association

Reduction of Human Intraocular Pressure with Intravenous Mannitol

Archives of Ophthalmology , Volume 68 (6) – Dec 1, 1962

Loading next page...
 
/lp/american-medical-association/reduction-of-human-intraocular-pressure-with-intravenous-mannitol-VNKoGj0T1t
Publisher
American Medical Association
Copyright
Copyright © 1962 American Medical Association. All Rights Reserved.
ISSN
0003-9950
eISSN
1538-3687
DOI
10.1001/archopht.1962.00960030738007
Publisher site
See Article on Publisher Site

Abstract

Abstract The reduction of intraocular pressure when this is acutely raised and prior to surgery is often essential. Osmotically acting urea has been used for this purpose during the past 2 years.1-11 It is desirable that such therapy should be both effective and free from harmful and annoying side-effects to the patient. This has not been entirely the case with urea which can produce uncontrollable diuresis, headaches analogous to postlumbar puncture headaches, necrosis of soft tissue, nausea and vomiting, arm pain, confusion, hyperthermia, a shock-like state,2 hypertension in labile hypertensives, thirst,7 and increase in blood volume with pulmonary edema.4 Hypertonic mannitol has been used to reduce intracranial pressures in animals and humans and would appear to be safe and effective for this purpose.13 The use of mannitol to reduce intraocular pressure was suggested to one of us by Dr. Shaffer on a recent visit to San References 1. Tarter, R. C., and Linn, J. G.: A Clinical Study of the Use of Intravenous Urea in Glaucoma , Amer. J. Ophthal. 52:323, 1961. 2. Crews, S. J., and Davidson, S. I.: Intravenous Urea Therapy in Glaucoma , Brit. J. Ophthal. 45: 769, 1961.Crossref 3. Fink, A. J.; Binkhorst, R. D., and Funahashi, R.: Intravenous Urea and Angle Closure Glaucoma , Amer. J. Ophthal. 52:872, 1961. 4. Ackerman, A. L.: The Action of Urea in Acute Glaucoma , Amer. J. Ophthal. 52:875, 1961. 5. Hill, K.; Whitney, J. B., and Trotter, R. R.: Intravenous Hypertonic Urea in the Management of Acute Angle-Closure Glaucoma , Arch. Ophthal. 65:497, 1961.Crossref 6. Davis, M. D.; Duehr, P. A., and Javid, M.: The Clinical Use of Urea for Reduction of Intraocular Pressure , Arch. Ophthal. 65:526, 1961.Crossref 7. Klöti, R.: The Indications for Intravenous Urea in Ophthalmology , Ophthalmologica 141:378, 1961.Crossref 8. Galin, M. A.; Nano, H. D., and Davidson, R. A.: Aqueous and Blood Urea Nitrogen Levels After Intravenous Urea Administration , Arch. Ophthal. 65:805, 1961.Crossref 9. Galin, M. A., and Baras, I.: Intravenous Urea in Retinal Detachment Surgery , Arch. Ophthal. 65:652, 1961.Crossref 10. Drance, S. M.: Unpublished data. 11. Klöti, R.: The Use of Urea in Glaucoma Therapy, Abstract , Amer. J. Ophthal. 51:355, 1961. 12. Weiss, D. I.; Shaffer, R. N., and Wise, B. L.: Mannitol Infusion to Reduce Intraocular Pressure , Arch. Ophthal. 68:341, 1962.Crossref 13. Wise, B. L., and Chater, N.: Effect of Mannitol on Cerebrospinal Fluid Pressure , Arch. Neurol. 4:200, 1961.Crossref

Journal

Archives of OphthalmologyAmerican Medical Association

Published: Dec 1, 1962

References