ORIGINAL ARTICLE Reduced Structural Connectivity of a Major Frontolimbic Pathway in Generalized Anxiety Disorder Do P. M. Tromp, MS; Daniel W. Grupe, MS; Desmond J. Oathes, PhD; Daniel R. McFarlin, PhD; Patric J. Hernandez, MPA; Tammi R. A. Kral, BS; Jee Eun Lee, PhD; Marie Adams, MS; Andrew L. Alexander, PhD; Jack B. Nitschke, PhD Context: Emotion regulation deficits figure promi- Main Outcome Measures: The mean fractional anisot- ropy values in the left and right uncinate fasciculus, as nently in generalized anxiety disorder (GAD) and in other measured by tract-based analysis for diffusion-tensor anxiety and mood disorders. Research examining emo- imaging data. tion regulation and top-down modulation has impli- cated reduced coupling of the amygdala with prefrontal Results: Lower mean fractional anisotropy values in the cortex and anterior cingulate cortex, suggesting altered bilateral uncinate fasciculus indicated reduced fronto- frontolimbic white matter connectivity in GAD. limbic structural connectivity in patients with GAD. This reduction in uncinate fasciculus integrity was most pro- Objectives: To investigate structural connectivity be- nounced for patients without comorbidity and was not tween ventral prefrontal cortex or anterior cingulate cor- observed in other white matter tracts. Across all partici- tex areas and the amygdala in GAD and
JAMA Psychiatry – American Medical Association
Published: Sep 1, 2012
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.