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Reduced Risks of Neural Tube Defects and Orofacial Clefts With Higher Diet Quality

Reduced Risks of Neural Tube Defects and Orofacial Clefts With Higher Diet Quality ARTICLE ONLINE FIRST |JOURNAL CLUB Reduced Risks of Neural Tube Defects and Orofacial Clefts With Higher Diet Quality Suzan L. Carmichael, PhD; Wei Yang, MD, MS, MA; Marcia Lynn Feldkamp, PhD, PA, MSPH; Ronald G. Munger, PhD; Anna Maria Siega-Riz, PhD; Lorenzo D. Botto, MD; Gary Shaw, DrPH; for the National Birth Defects Prevention Study Objective: To examine whether better maternal diet Results: After covariate adjustment, increasing diet qual- quality was associated with reduced risk for selected birth ity based on either index was associated with reduced risks defects. for the birth defects studied. The strongest association was between anencephaly and DQI; the OR for highest Design: A multicenter, population-based case-control vs lowest quartile was 0.49 (95% CI, 0.31-0.75). The ORs study, the National Birth Defects Prevention Study. for cleft lip with or without cleft palate and cleft palate and DQI were also notable (0.66 [95% CI, 0.54-0.81] and Setting: Ten participating centers in the United States. 0.74 [95%CI, 0.56-0.96], respectively). Participants: Eligible subjects’ estimated due dates were Conclusions: Healthier maternal dietary patterns, as mea- from October 1997 through December 2005. Tele- sured by diet quality scores, were associated with re- phone interviews were conducted with 72% of case http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA Pediatrics American Medical Association

Reduced Risks of Neural Tube Defects and Orofacial Clefts With Higher Diet Quality

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References (44)

Publisher
American Medical Association
Copyright
Copyright 2012 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
2168-6203
eISSN
2168-6211
DOI
10.1001/archpediatrics.2011.185
pmid
21969361
Publisher site
See Article on Publisher Site

Abstract

ARTICLE ONLINE FIRST |JOURNAL CLUB Reduced Risks of Neural Tube Defects and Orofacial Clefts With Higher Diet Quality Suzan L. Carmichael, PhD; Wei Yang, MD, MS, MA; Marcia Lynn Feldkamp, PhD, PA, MSPH; Ronald G. Munger, PhD; Anna Maria Siega-Riz, PhD; Lorenzo D. Botto, MD; Gary Shaw, DrPH; for the National Birth Defects Prevention Study Objective: To examine whether better maternal diet Results: After covariate adjustment, increasing diet qual- quality was associated with reduced risk for selected birth ity based on either index was associated with reduced risks defects. for the birth defects studied. The strongest association was between anencephaly and DQI; the OR for highest Design: A multicenter, population-based case-control vs lowest quartile was 0.49 (95% CI, 0.31-0.75). The ORs study, the National Birth Defects Prevention Study. for cleft lip with or without cleft palate and cleft palate and DQI were also notable (0.66 [95% CI, 0.54-0.81] and Setting: Ten participating centers in the United States. 0.74 [95%CI, 0.56-0.96], respectively). Participants: Eligible subjects’ estimated due dates were Conclusions: Healthier maternal dietary patterns, as mea- from October 1997 through December 2005. Tele- sured by diet quality scores, were associated with re- phone interviews were conducted with 72% of case

Journal

JAMA PediatricsAmerican Medical Association

Published: Feb 1, 2012

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