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ARTICLE ONLINE FIRST |JOURNAL CLUB Reduced Risks of Neural Tube Defects and Orofacial Clefts With Higher Diet Quality Suzan L. Carmichael, PhD; Wei Yang, MD, MS, MA; Marcia Lynn Feldkamp, PhD, PA, MSPH; Ronald G. Munger, PhD; Anna Maria Siega-Riz, PhD; Lorenzo D. Botto, MD; Gary Shaw, DrPH; for the National Birth Defects Prevention Study Objective: To examine whether better maternal diet Results: After covariate adjustment, increasing diet qual- quality was associated with reduced risk for selected birth ity based on either index was associated with reduced risks defects. for the birth defects studied. The strongest association was between anencephaly and DQI; the OR for highest Design: A multicenter, population-based case-control vs lowest quartile was 0.49 (95% CI, 0.31-0.75). The ORs study, the National Birth Defects Prevention Study. for cleft lip with or without cleft palate and cleft palate and DQI were also notable (0.66 [95% CI, 0.54-0.81] and Setting: Ten participating centers in the United States. 0.74 [95%CI, 0.56-0.96], respectively). Participants: Eligible subjects’ estimated due dates were Conclusions: Healthier maternal dietary patterns, as mea- from October 1997 through December 2005. Tele- sured by diet quality scores, were associated with re- phone interviews were conducted with 72% of case
JAMA Pediatrics – American Medical Association
Published: Feb 1, 2012
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