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Red Cell Lipids

Red Cell Lipids Abstract The great current interest in plasma fats and their relation to disorders of obvious clinical importance (e. g., arteriosclerosis) has tended to obscure in some degree certain other recent developments in knowledge of lipid metabolism. Among these, it is possible to record for the lipids of the red blood cell advances in our knowledge of their composition as well as a beginning of understanding of the dynamics of their metabolism. While it is too soon to appraise the importance of such researches for medicine, they appear to bear upon at least two old and interrelated problems of physiology. The first of these concerns the architecture of the cell, especially its membranes. It has long been supposed that phospholipids have important structural functions, including those concerned with maintaining the characteristic cellular permeability. The second problem is that of metabolic activity, changes in which may be associated, for example, with hemolytic disease References 1. Muir, H. M.; Neuberger, A., and Perrone, J. C.: Further Isotopic Studies on Hemoglobin Formation in the Rat and Rabbit , Biochem. J. 52:87-95, 1952. 2. James, A. T.; Lovelock, J. E., and Webb, J.: The Biosynthesis of Fatty Acids by Human Red Blood Cells , Biochem. J. 66:60P, 1957. 3. Folch, J.: The Chemistry of Phosphatides , in Phosphorus Metabolism , Baltimore, The Johns Hopkins Press, 1952, Vol. 2, pp. 186-200. 4. Axelrod, J.; Reichenthal, J., and Brodie, B. B.: The Direct Determination of Phosphatidyl Ethanolamine and Phosphatidyl Serine in Plasma and Red Blood Cells , J. Biol. Chem. 204:903-911, 1953. 5. Lea, C. H.; Rhodes, D. N., and Stoll, R. D.: Phospholipids: 3. On the Chromatographic Separation of Glycerophospholipids , Biochem. J. 60: 353-363, 1955. 6. Turner, J. C.: Absence of Lecithin from the Stromata of the Red Cells of Certain Animals and Its Relation to Venom Hemolysis , J. Exper. Med. 105:189-193, 1957.Crossref 7. Hack, M. H.: Estimation of the Phospholipides in Human Blood , J. Biol. Chem. 169:137-143, 1947. 8. Klenk, E., and Lauenstein, K.: Über die zuckerhaltigen Lipoide des Erythrocytenstromas von Mensch und Rind , Ztschr. physiol. Chem. 291:249-258, 1952. 9. Yamakawa, T., and Suzuki, S.: The Chemistry of the Lipids of Posthemolytic Residue of Stroma of Erythrocytes , J. Biochem. 38:199-212, 1951. 10. James, A. T., and Martin, A. J. P.: Gas-Liquid Chromatography , Brit. M. Bull. 10:170-176, 1954. 11. James, A. T.; Lovelock, J. E.; Webb, J., and Trotter, W. R.: The Fatty Acids of the Blood in Coronary Artery Disease , Lancet 1:705-708, 1957.Crossref 12. London, I. M., and Schwarz, H.: Erythrocyte Metabolism: The Metabolic Behavior of the Cholesterol of Human Erythrocytes , J. Clin. Invest. 32:1248-1252, 1953.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png A.M.A. Archives of Internal Medicine American Medical Association

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Publisher
American Medical Association
Copyright
Copyright © 1958 American Medical Association. All Rights Reserved.
ISSN
0888-2479
DOI
10.1001/archinte.1958.00260140142021
Publisher site
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Abstract

Abstract The great current interest in plasma fats and their relation to disorders of obvious clinical importance (e. g., arteriosclerosis) has tended to obscure in some degree certain other recent developments in knowledge of lipid metabolism. Among these, it is possible to record for the lipids of the red blood cell advances in our knowledge of their composition as well as a beginning of understanding of the dynamics of their metabolism. While it is too soon to appraise the importance of such researches for medicine, they appear to bear upon at least two old and interrelated problems of physiology. The first of these concerns the architecture of the cell, especially its membranes. It has long been supposed that phospholipids have important structural functions, including those concerned with maintaining the characteristic cellular permeability. The second problem is that of metabolic activity, changes in which may be associated, for example, with hemolytic disease References 1. Muir, H. M.; Neuberger, A., and Perrone, J. C.: Further Isotopic Studies on Hemoglobin Formation in the Rat and Rabbit , Biochem. J. 52:87-95, 1952. 2. James, A. T.; Lovelock, J. E., and Webb, J.: The Biosynthesis of Fatty Acids by Human Red Blood Cells , Biochem. J. 66:60P, 1957. 3. Folch, J.: The Chemistry of Phosphatides , in Phosphorus Metabolism , Baltimore, The Johns Hopkins Press, 1952, Vol. 2, pp. 186-200. 4. Axelrod, J.; Reichenthal, J., and Brodie, B. B.: The Direct Determination of Phosphatidyl Ethanolamine and Phosphatidyl Serine in Plasma and Red Blood Cells , J. Biol. Chem. 204:903-911, 1953. 5. Lea, C. H.; Rhodes, D. N., and Stoll, R. D.: Phospholipids: 3. On the Chromatographic Separation of Glycerophospholipids , Biochem. J. 60: 353-363, 1955. 6. Turner, J. C.: Absence of Lecithin from the Stromata of the Red Cells of Certain Animals and Its Relation to Venom Hemolysis , J. Exper. Med. 105:189-193, 1957.Crossref 7. Hack, M. H.: Estimation of the Phospholipides in Human Blood , J. Biol. Chem. 169:137-143, 1947. 8. Klenk, E., and Lauenstein, K.: Über die zuckerhaltigen Lipoide des Erythrocytenstromas von Mensch und Rind , Ztschr. physiol. Chem. 291:249-258, 1952. 9. Yamakawa, T., and Suzuki, S.: The Chemistry of the Lipids of Posthemolytic Residue of Stroma of Erythrocytes , J. Biochem. 38:199-212, 1951. 10. James, A. T., and Martin, A. J. P.: Gas-Liquid Chromatography , Brit. M. Bull. 10:170-176, 1954. 11. James, A. T.; Lovelock, J. E.; Webb, J., and Trotter, W. R.: The Fatty Acids of the Blood in Coronary Artery Disease , Lancet 1:705-708, 1957.Crossref 12. London, I. M., and Schwarz, H.: Erythrocyte Metabolism: The Metabolic Behavior of the Cholesterol of Human Erythrocytes , J. Clin. Invest. 32:1248-1252, 1953.Crossref

Journal

A.M.A. Archives of Internal MedicineAmerican Medical Association

Published: Feb 1, 1958

References