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Red Blood Cell Distribution Width and Mortality Risk in a Community-Based Prospective Cohort

Red Blood Cell Distribution Width and Mortality Risk in a Community-Based Prospective Cohort ORIGINAL INVESTIGATION Red Blood Cell Distribution Width and Mortality Risk in a Community-Based Prospective Cohort Todd S. Perlstein, MD, MMSc; Jennifer Weuve, ScD; Marc A. Pfeffer, MD, PhD; Joshua A. Beckman, MD, MSc Background: Red blood cell distribution width (RDW), ing for age and 2-fold after multivariable adjustment an automated measure of red blood cell size heteroge- (P .001 for each). A 1–SD increment in RDW (0.98%) trend neity (eg, anisocytosis) that is largely overlooked, is a newly was associated with a 23% greater risk of all-cause mor- recognized risk marker in patients with established car- tality (hazard ratio [HR], 1.23; 95% confidence interval diovascular disease (CVD). It is unknown whether RDW [CI], 1.18-1.28) after multivariable adjustment. The RDW is associated with mortality in the general population or was also associated with risk of death due to CVD (HR, whether this association is specific to CVD. 1.22; 95% CI, 1.14-1.31), cancer (1.28; 1.21-1.36), and chronic lower respiratory tract disease (1.32; 1.17- Methods: We examined the association of RDW with 1.49). all-cause mortality and with CVD, cancer, and chronic lower respiratory tract disease mortality in 15 852 adult Conclusions: Higher RDW is associated with in- participants in the Third National http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA Internal Medicine American Medical Association

Red Blood Cell Distribution Width and Mortality Risk in a Community-Based Prospective Cohort

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References (23)

Publisher
American Medical Association
Copyright
Copyright 2009 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
2168-6106
eISSN
2168-6114
DOI
10.1001/archinternmed.2009.55
pmid
19307522
Publisher site
See Article on Publisher Site

Abstract

ORIGINAL INVESTIGATION Red Blood Cell Distribution Width and Mortality Risk in a Community-Based Prospective Cohort Todd S. Perlstein, MD, MMSc; Jennifer Weuve, ScD; Marc A. Pfeffer, MD, PhD; Joshua A. Beckman, MD, MSc Background: Red blood cell distribution width (RDW), ing for age and 2-fold after multivariable adjustment an automated measure of red blood cell size heteroge- (P .001 for each). A 1–SD increment in RDW (0.98%) trend neity (eg, anisocytosis) that is largely overlooked, is a newly was associated with a 23% greater risk of all-cause mor- recognized risk marker in patients with established car- tality (hazard ratio [HR], 1.23; 95% confidence interval diovascular disease (CVD). It is unknown whether RDW [CI], 1.18-1.28) after multivariable adjustment. The RDW is associated with mortality in the general population or was also associated with risk of death due to CVD (HR, whether this association is specific to CVD. 1.22; 95% CI, 1.14-1.31), cancer (1.28; 1.21-1.36), and chronic lower respiratory tract disease (1.32; 1.17- Methods: We examined the association of RDW with 1.49). all-cause mortality and with CVD, cancer, and chronic lower respiratory tract disease mortality in 15 852 adult Conclusions: Higher RDW is associated with in- participants in the Third National

Journal

JAMA Internal Medicine – American Medical Association

Published: Mar 23, 2009

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