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Recurrent Seizures After Diphtheria, Tetanus, and Pertussis Vaccine Immunization: Onset Less Than 24 Hours After Vaccination

Recurrent Seizures After Diphtheria, Tetanus, and Pertussis Vaccine Immunization: Onset Less Than... Abstract • Twenty-two patients with recurrent seizures that started less than 24 hours after immunization with diphtheria, tetanus, and pertussis (DTP) vaccine were retrospectively studied. The initial seizure generally occurred after one of the first three DTP vaccine immunizations, and followed that immunization by less than 12 hours. Two of the 22 patients were siblings. Eight patients had additional immunizations with DTP vaccine and four had immediate worsening of their seizures. Of the 22 patients, only one was seizure free and stopped taking anticonvulsants. Three patients exhibited normal development, and 11 had severe developmental delays. Based on these observations, we reviewed current contraindications for immunization with pertussis vaccine. (AJDC 1984;138:908-911) References 1. Madsen T: Vaccination against whooping cough . JAMA 1933;101:187-188.Crossref 2. Byers RK, Moll FC: Encephalopathies following prophylactic pertussis vaccine . Pediatrics 1948;1:437-456. 3. Kulenkampff M, Schwartzman JS, Wilson J: Neurologic complications of pertussis inoculation . Arch Dis Child 1974;49:46-49.Crossref 4. Aicardi J, Chevrie JJ: Accidents neurologiques consecutifs a la vaccination contre la coqueluche . Arch Fr Pediatr 1975;32:309-318. 5. Cody CL, Baraff LJ, Cherry JD, et al: Nature and rates of adverse reactions associated with DPT and DT immunizations in infants and children . Pediatrics 1981;68:650-660. 6. Hirtz DG, Nelson KB, Ellenberg JH: Seizures following childhood immunizations . J Pediatr 1983;102:14-18.Crossref 7. Miller DL, Ross EM, Alderslade R, et al: Pertussis immunization and serious acute neurological illness in children . Br Med J 1981;282: 1595-1599.Crossref 8. Hull D: Interpretation of the contraindications to whooping cough vaccination . Br Med J 1981;283:1231-1233.Crossref 9. Report of the Committee on Infectious Diseases of the American Academy of Pediatrics , ed 19, Evanston, Ill, American Academy of Pediatrics, 1982, pp 200-202. 10. Bellman MH, Ross EM, Miller DL: Infantile spasms and pertussis immunization . Lancet 1983;1:1031-1033.Crossref 11. Steinman L, Sureim S, Adelman NE, et al: Murine model for pertussis vaccine encephalopathy: Linkage to H-2 . Nature 1982;299:738-740.Crossref 12. Annegers JF, Hauser WA, Anderson VE, et al: The risks of seizure disorders among relatives of patients with childhood epilepsy . Neurology 1982;32:174-179.Crossref 13. Baraff LJ, Cherry JD, Cody CL, et al: Pertussis Vaccine Project: Rates, Nature and Etiology of Adverse Reactions Associated With DPT Vaccine: September 30, 1977–December 13, 1979 . Springfield, Va, Department of Commerce, National Technical Information Service, 1980, p 38. 14. Manclark CR, Manclark HJC (eds): Third International Symposium on Pertussis , US Dept of Health, Education and Welfare, publication (NIH) 79-1830, 1970. 15. Miller DL, Alderslade R, Ross EM: Whooping cough and whooping cough vaccine: The risks and benefit debate . Epidemiol Rev 1982;4:1-24. 16. Kanai K: Japan's experience in pertussis epidemiology and vaccination in the past 30 years . Jpn J Med Sci Biol 1980;33:107-143.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of Diseases of Children American Medical Association

Recurrent Seizures After Diphtheria, Tetanus, and Pertussis Vaccine Immunization: Onset Less Than 24 Hours After Vaccination

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Publisher
American Medical Association
Copyright
Copyright © 1984 American Medical Association. All Rights Reserved.
ISSN
0002-922X
DOI
10.1001/archpedi.1984.02140480010004
Publisher site
See Article on Publisher Site

Abstract

Abstract • Twenty-two patients with recurrent seizures that started less than 24 hours after immunization with diphtheria, tetanus, and pertussis (DTP) vaccine were retrospectively studied. The initial seizure generally occurred after one of the first three DTP vaccine immunizations, and followed that immunization by less than 12 hours. Two of the 22 patients were siblings. Eight patients had additional immunizations with DTP vaccine and four had immediate worsening of their seizures. Of the 22 patients, only one was seizure free and stopped taking anticonvulsants. Three patients exhibited normal development, and 11 had severe developmental delays. Based on these observations, we reviewed current contraindications for immunization with pertussis vaccine. (AJDC 1984;138:908-911) References 1. Madsen T: Vaccination against whooping cough . JAMA 1933;101:187-188.Crossref 2. Byers RK, Moll FC: Encephalopathies following prophylactic pertussis vaccine . Pediatrics 1948;1:437-456. 3. Kulenkampff M, Schwartzman JS, Wilson J: Neurologic complications of pertussis inoculation . Arch Dis Child 1974;49:46-49.Crossref 4. Aicardi J, Chevrie JJ: Accidents neurologiques consecutifs a la vaccination contre la coqueluche . Arch Fr Pediatr 1975;32:309-318. 5. Cody CL, Baraff LJ, Cherry JD, et al: Nature and rates of adverse reactions associated with DPT and DT immunizations in infants and children . Pediatrics 1981;68:650-660. 6. Hirtz DG, Nelson KB, Ellenberg JH: Seizures following childhood immunizations . J Pediatr 1983;102:14-18.Crossref 7. Miller DL, Ross EM, Alderslade R, et al: Pertussis immunization and serious acute neurological illness in children . Br Med J 1981;282: 1595-1599.Crossref 8. Hull D: Interpretation of the contraindications to whooping cough vaccination . Br Med J 1981;283:1231-1233.Crossref 9. Report of the Committee on Infectious Diseases of the American Academy of Pediatrics , ed 19, Evanston, Ill, American Academy of Pediatrics, 1982, pp 200-202. 10. Bellman MH, Ross EM, Miller DL: Infantile spasms and pertussis immunization . Lancet 1983;1:1031-1033.Crossref 11. Steinman L, Sureim S, Adelman NE, et al: Murine model for pertussis vaccine encephalopathy: Linkage to H-2 . Nature 1982;299:738-740.Crossref 12. Annegers JF, Hauser WA, Anderson VE, et al: The risks of seizure disorders among relatives of patients with childhood epilepsy . Neurology 1982;32:174-179.Crossref 13. Baraff LJ, Cherry JD, Cody CL, et al: Pertussis Vaccine Project: Rates, Nature and Etiology of Adverse Reactions Associated With DPT Vaccine: September 30, 1977–December 13, 1979 . Springfield, Va, Department of Commerce, National Technical Information Service, 1980, p 38. 14. Manclark CR, Manclark HJC (eds): Third International Symposium on Pertussis , US Dept of Health, Education and Welfare, publication (NIH) 79-1830, 1970. 15. Miller DL, Alderslade R, Ross EM: Whooping cough and whooping cough vaccine: The risks and benefit debate . Epidemiol Rev 1982;4:1-24. 16. Kanai K: Japan's experience in pertussis epidemiology and vaccination in the past 30 years . Jpn J Med Sci Biol 1980;33:107-143.Crossref

Journal

American Journal of Diseases of ChildrenAmerican Medical Association

Published: Oct 1, 1984

References