Abstract • A patient with recurrent middle ear infections may have an underlying disease that causes him to have an increased susceptibility to infection. An 8-year-old boy had recurrent otitis media in association with common variable immunodeficiency (VID). HLA typing and in vitro tests for lymphocyte function were carried out on members of his family, and results suggested that the mother's HLA haplotypes might provide a link to low responsiveness of lymphocytes to one of the streptococcal cell wall antigens. The site of lesion of B-cell differentiation and immunological and clinical aspects of VID are discussed. (Arch Otolaryngol 1982;108:204-207) References 1. Paradise JL: Otitis media in infants and children . Pediatrics 1980;65:917-943. 2. Qvarnberg Y: Acute otitis media: A prospective clinical study of myringotomy and antimicrobial treatment . Acta Otolaryngol 1981;375 ( (suppl) ):1-157. 3. Hill HR, Book LS, Hemming VG, et al: Defective neutrophil chemotactic responses in patients with recurrent episodes of otitis media and chronic diarrhea . Am J Dis Child 1977; 131:433-436. 4. Sacchi FT, Ferrari FA, Fortunato A, et al: A defect in neutrophil motility in two siblings with recurrent infections and a remarkable family history . Infection 1979;7:45-47.Crossref 5. Juhlin L, Nichaelsson G: A new syndrome characterized by absence of eosinophils and basophils . Lancet 1977;1:1233-1235.Crossref 6. Fischer TJ, McAdams JA, Entis GN, et al: Middle ear ciliary defect in Kartagener's syndrome . Pediatrics 1978;62:443-445. 7. Kimmerlmann CP, Potsic WP: Immunodeficiency in pediatric otolaryngology . Am J Otolaryngol 1979;1:33-38.Crossref 8. Sasaki CT, Askenase P, Dwyer J, et al: Chronic ear infection in the immunodeficient patient . Arch Otolaryngol 1981;107:82-86.Crossref 9. Sasazuki T, Kaneoka H, Nishimura Y, et al: An HLA-linked immune suppression gene in man . J Exp Med 1980;152:297-313. 10. Matsumoto S: Classification and diagnostics criteria of primary immunodeficiency disease . Jpn J Pediatr 1977;30:989-999. 11. Fudenberg H, Good RA, Goodman HC, et al: Primary immunodeficiencies: Report of a World Health Organization Committee . Pediatrics 1971;47:927-946. 12. Geha RS, Schneeberger E, Merler E, et al: Heterogeneity of 'acquired' or common variable agammaglobulinemia . N Engl J Med 1974;291:1-6.Crossref 13. Hermans PE, Diaz-Buxo JA, Stobo JD: Idiopathic late-onset immunoglobulin deficiency: Clinical observations in 50 patients . Am J Med 1976;61:221-237.Crossref 14. Matsumoto S: Heterogeneity of primary hypogammaglobulinemia: Relations between abnormalities of B-lymphocyte differentiations and the developments of hypogammaglobulinemias . Saishin-Igaku (Jpn) 1977;32:618-624. 15. Choi YS, Biggar WD, Good RA: Biosynthesis and secretion of immunoglobulins by peripheral-blood lymphocytes in severe hypogammaglobulinemia . Lancet 1972;1:1149-1152.Crossref 16. Waldmann TA, Durm M, Broder S, et al: Role of suppressor T cells in pathogenesis of common variable hypogammaglobulinemia . Lancet 1974;2:609-613.Crossref 17. Chipps BE, Talamo RC, Winkelstein JA: IgA deficiency, recurrent pneumonias, and bronchiectasis . Chest 1978;73:519-526.Crossref 18. Ogra PL, Bernstein JM, Yurchak AM, et al: Characteristics of secretory immune system in human middle ear: Implications in otitis media . J Immunol 1974;112:488-495. 19. Mogi G, Maeda S, Yoshida T, et al: Immunochemistry of otitis media with effusion . J Infect Dis 1976;133:126-136.Crossref 20. Lewis DM, Schram JL, Meadema SJ, et al: Experimental otitis media in chinchillas . Ann Otol Rhinol Laryngol 1980;89( (suppl 68) ):344-350. 21. Mogi G, Maeda S, Watanabe N: The development of mucosal immunity in guinea pig middle ears . Int J Pediatr Otorhinolaryngol 1980; 1:331-349.Crossref 22. Yata J: Immunodeficiency diseases . Metabol Dis (Jpn) 1975;12:801-809.
Archives of Otolaryngology – American Medical Association
Published: Apr 1, 1982
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