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Recurrent Cushing's Syndrome with Trichophyton Rubrum Infection

Recurrent Cushing's Syndrome with Trichophyton Rubrum Infection Abstract The effects of adrenal hypercorticism on bacterial infections are well recognized. The effects of hypercorticism on mycotic infections are not as widely appreciated. The following case warrants reporting because the patient shows dramatically the effect of hyperadrenocorticism on a Trichophyton rubrum infection. The steroid assays on this patient with adrenal hyperplasia and adenomas were within the levels usually found in adrenal malignancy. Report of a Case A white married engineer, aged 30, was seen at the Clinic in June, 1954, because of progressive weakness of six months' duration, obesity, known hypertension, and a dermatitis which had first appeared in September of 1953. Pertinent physical findings at that time were moderate obesity (height 72 in., weight 220 lb.), a blood pressure of 200/140 (which dropped rapidly to 140/100 on bed rest and reserpine), and electrocardiographic evidence of early left ventricular hypertrophy. Erythematous, scaling plaques, more active at References 1. Bratlund, H., and Holten, C.: Moniliasis of the Mucous Membrane and the Lungs as a Complication of Treatment with Antibiotics Corticotropin, and Cortisone , Danish M. Bull. 1:79 ( (June) ) 1954. 2. Burns, R. E.: Fungous Disease as a Complication of Steroid Therapy , A.M.A. Arch. Dermat. 77:686 ( (June) ) 1958.Crossref 3. Cremer, G.: The Influence of Adrenocortical Hormones on Dermatomycoses, Especially in the Cushing Syndrome , Dermatologica 111:285 ( (Nov.) ) 1955.Crossref 4. Curth, H. D.: In discussion of Newcomer et al.13 5. Engleman, E. P., Krupp, M. A., and Molyneaux, M. G.: Clinical Experiences with Cortisone (Coccidioidomycosis) in U.S. Veterans Administration Conference on Cortisone Research, August, 1950 , Rahway, N.J., Merck & Co., Inc., 1951, 28-30. 6. Fergusson, A. G.; DeWar, W. A., and Milne, J. A.: Steroid Therapy in Reticulosis of the Skin with Special References to Exfoliative Dermatitis , Brit. J. Dermat. 70:58 ( (Feb.) ) 1958.Crossref 7. Jadassohn, W., Mach, R. S., and Nardin, J.: Effet de la cortisone sur la mycose expérimentale du cobaye , Acta endocrinol. 6:351, 1951. 8. Jahn, J. P., et al: The Combination of ACTH-Cortisone-Hydrocortisone with Antibiotics in the Management of Overwhelmingly Severe Infections , J. Pediat. 44:640 ( (June) ) 1954.Crossref 9. Jawetz, E.: Effect of Cortisone on Therapeutic Efficacy of Antibiotics in Experimental Infections , A.M.A. Arch. Int. Med. 93:850 ( (June) ) 1954.Crossref 10. Kass, E. H.: Adrenocortical Steroids and the Management of Infectious Diseases , A.M.A. Arch. Int. Med. 102:1 ( (July) ) 1958.Crossref 11. Kass, E. H., and Finland, M.: Mechanisms Involved in Decreased Resistance to Infection , Ann. Rev. Microbiol. 7:377, 1953.Crossref 12. Levan, N. E., and Einstein, H. E.: Cortisone in Coccidioidomycosis , California Med. 84: 193 ( (March) ) 1956. 13. Newcomer, V. D., Wright, E. T., Tarbet, J. E., Winer, L. H., and Sternberg, T. H.: The Effect of Cortisone on Experimental Coccidioidomycosis , J. Invest. Dermat. 20:315 ( (April) ) 1953. 14. Pillsbury, D. M., and Jacobson, C.: Cushing's Syndrome Complicated by Generalized Trichophyton Rubrum Infection , A.M.A. Arch. Dermat. & Syph. 67:436 ( (April) ) 1953. 15. Reiss, F., and Caroline, L.: The Influence of ACTH and Cortisone upon Experimental Achorian Quinckeanum Infection and upon Anaphylaxis in Guinea Pigs , J. Invest. Dermat. 19:365 ( (Nov.) ) 1952. 16. Rothman, S.: Systemic Disturbances in Recalcitrant Trichophyton Rubrum (Purpureum) Infections , A.M.A. Arch. Dermat. & Syph. 67:239 ( (March) ) 1953. 17. Scheer, G. H.: The Effects of Cortisone on the Course of Systemic Moniliasis in Mice , Mycopath. et mycol. appl. 6:325, 1953. 18. Shields, T. L.: Observation on Steroid Therapy for Kerion, The Schoch Letter, Dec. 1958. 19. Silverman, F. N., Schwarz, J., Lahey, M. E., and Carson, R. P.: Histoplasmosis , Am. J. Med. 19:410 ( (Sept.) ) 1955. 20. Smith, F. P., and Cleve, E. A.: Infections Complicating Cortisone Therapy , New England J. Med. 256:104 ( (Jan. 17) ) 1957. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png A.M.A. Archives of Dermatology American Medical Association

Recurrent Cushing's Syndrome with Trichophyton Rubrum Infection

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Publisher
American Medical Association
Copyright
Copyright © 1959 American Medical Association. All Rights Reserved.
ISSN
0096-5359
DOI
10.1001/archderm.1959.01560240052006
Publisher site
See Article on Publisher Site

Abstract

Abstract The effects of adrenal hypercorticism on bacterial infections are well recognized. The effects of hypercorticism on mycotic infections are not as widely appreciated. The following case warrants reporting because the patient shows dramatically the effect of hyperadrenocorticism on a Trichophyton rubrum infection. The steroid assays on this patient with adrenal hyperplasia and adenomas were within the levels usually found in adrenal malignancy. Report of a Case A white married engineer, aged 30, was seen at the Clinic in June, 1954, because of progressive weakness of six months' duration, obesity, known hypertension, and a dermatitis which had first appeared in September of 1953. Pertinent physical findings at that time were moderate obesity (height 72 in., weight 220 lb.), a blood pressure of 200/140 (which dropped rapidly to 140/100 on bed rest and reserpine), and electrocardiographic evidence of early left ventricular hypertrophy. Erythematous, scaling plaques, more active at References 1. Bratlund, H., and Holten, C.: Moniliasis of the Mucous Membrane and the Lungs as a Complication of Treatment with Antibiotics Corticotropin, and Cortisone , Danish M. Bull. 1:79 ( (June) ) 1954. 2. Burns, R. E.: Fungous Disease as a Complication of Steroid Therapy , A.M.A. Arch. Dermat. 77:686 ( (June) ) 1958.Crossref 3. Cremer, G.: The Influence of Adrenocortical Hormones on Dermatomycoses, Especially in the Cushing Syndrome , Dermatologica 111:285 ( (Nov.) ) 1955.Crossref 4. Curth, H. D.: In discussion of Newcomer et al.13 5. Engleman, E. P., Krupp, M. A., and Molyneaux, M. G.: Clinical Experiences with Cortisone (Coccidioidomycosis) in U.S. Veterans Administration Conference on Cortisone Research, August, 1950 , Rahway, N.J., Merck & Co., Inc., 1951, 28-30. 6. Fergusson, A. G.; DeWar, W. A., and Milne, J. A.: Steroid Therapy in Reticulosis of the Skin with Special References to Exfoliative Dermatitis , Brit. J. Dermat. 70:58 ( (Feb.) ) 1958.Crossref 7. Jadassohn, W., Mach, R. S., and Nardin, J.: Effet de la cortisone sur la mycose expérimentale du cobaye , Acta endocrinol. 6:351, 1951. 8. Jahn, J. P., et al: The Combination of ACTH-Cortisone-Hydrocortisone with Antibiotics in the Management of Overwhelmingly Severe Infections , J. Pediat. 44:640 ( (June) ) 1954.Crossref 9. Jawetz, E.: Effect of Cortisone on Therapeutic Efficacy of Antibiotics in Experimental Infections , A.M.A. Arch. Int. Med. 93:850 ( (June) ) 1954.Crossref 10. Kass, E. H.: Adrenocortical Steroids and the Management of Infectious Diseases , A.M.A. Arch. Int. Med. 102:1 ( (July) ) 1958.Crossref 11. Kass, E. H., and Finland, M.: Mechanisms Involved in Decreased Resistance to Infection , Ann. Rev. Microbiol. 7:377, 1953.Crossref 12. Levan, N. E., and Einstein, H. E.: Cortisone in Coccidioidomycosis , California Med. 84: 193 ( (March) ) 1956. 13. Newcomer, V. D., Wright, E. T., Tarbet, J. E., Winer, L. H., and Sternberg, T. H.: The Effect of Cortisone on Experimental Coccidioidomycosis , J. Invest. Dermat. 20:315 ( (April) ) 1953. 14. Pillsbury, D. M., and Jacobson, C.: Cushing's Syndrome Complicated by Generalized Trichophyton Rubrum Infection , A.M.A. Arch. Dermat. & Syph. 67:436 ( (April) ) 1953. 15. Reiss, F., and Caroline, L.: The Influence of ACTH and Cortisone upon Experimental Achorian Quinckeanum Infection and upon Anaphylaxis in Guinea Pigs , J. Invest. Dermat. 19:365 ( (Nov.) ) 1952. 16. Rothman, S.: Systemic Disturbances in Recalcitrant Trichophyton Rubrum (Purpureum) Infections , A.M.A. Arch. Dermat. & Syph. 67:239 ( (March) ) 1953. 17. Scheer, G. H.: The Effects of Cortisone on the Course of Systemic Moniliasis in Mice , Mycopath. et mycol. appl. 6:325, 1953. 18. Shields, T. L.: Observation on Steroid Therapy for Kerion, The Schoch Letter, Dec. 1958. 19. Silverman, F. N., Schwarz, J., Lahey, M. E., and Carson, R. P.: Histoplasmosis , Am. J. Med. 19:410 ( (Sept.) ) 1955. 20. Smith, F. P., and Cleve, E. A.: Infections Complicating Cortisone Therapy , New England J. Med. 256:104 ( (Jan. 17) ) 1957.

Journal

A.M.A. Archives of DermatologyAmerican Medical Association

Published: Dec 1, 1959

References