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Rectal Motility Patterns in Infants and Children With Aganglionic Megacolon

Rectal Motility Patterns in Infants and Children With Aganglionic Megacolon Abstract Rectal activity patterns were obtained in 15 children with aganglionic megacolon by open-tipped catheter and were compared with 51 normal children. Bethanechol chloride (Urecholine) was given to six children with aganglionic megacolon and six well children without gastrointestinal complaints, and the responses were evaluated. An increased motor activity during resting periods and a heightened response to cholinergic stimulation with increased wave amplitude were demonstrated in the children with aganglionic megacolon. This evidence supports a concept of spastic contractility in the aganglionic segment of Hirschsprung's disease. References 1. Kamijo K, Hiatt RB, Koelle GB: Congenital megacolon: A comparison of the spastic and hypertrophied segments with respect to cholinesterase activities and sensitivities to acetylcholine: DFP and the barium ion . Gastroenterology 24:173-185, 1953. 2. Whitehouse FR, Kernohan JW: Myenteric plexus in congenital megacolon . Arch Intern Med 82:75-111, 1948.Crossref 3. Ehrenpreis T: Some newer aspects on Hirschsprung's disease and allied disorders . J Pediat Surg 1:329-337, 1966.Crossref 4. Swenson O, Rheinlander FH, Diamond I: Hirschsprung's disease: A new concept of the etiology . New Eng J Med 241:551-556, 1949.Crossref 5. Davidson M, Sleisenger HT, Steinberg H, et al: Studies of distal colonic motility in children: III. The pathologic physiology of congenital megacolon . Gastroenterology 29:803-823, 1955. 6. Hiatt RB: The pathologic physiology of congenital megacolon . Ann Surg 133:313-320, 1951.Crossref 7. Davidson M, Sleisenger MH, Almy TP, et al: Studies in distal colonic motility in children: I. Nonpropulsive patterns in normal children . Pediatrics 17:807-820, 1956. 8. Kim IC, Barbero GJ: The pattern of rectosigmoid motility in children . Gastroenterology 45: 57-66, 1963. 9. Code CF, Hightower NC Jr, Morlock CG: Motility of the alimentary canal in man: Review of recent studies . Amer J Med 13:328-351, 1952.Crossref 10. Cannon WB: A law of denervation . Amer J Med Sci 198:737-750, 1939.Crossref 11. Hope WJ, Borns FP, Berg KP: Roentgenologic manifestations of Hirschsprung's disease in infancy . Amer J Roentgen 95:217-229, 1965.Crossref 12. Tobon F, Reid NCRW, Talbert LJ, et al: Non-surgical test for the diagnosis of Hirschsprung's disease . New Eng J Med 278:188-194, 1968.Crossref 13. Ehrenpreis TH, Norberg KA, Wirsen C: Sympathetic innervation of the colon in Hirschsprung's disease: A histochemical study . J Pediat Surg 3:43-49, 1968.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of Diseases of Children American Medical Association

Rectal Motility Patterns in Infants and Children With Aganglionic Megacolon

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Publisher
American Medical Association
Copyright
Copyright © 1970 American Medical Association. All Rights Reserved.
ISSN
0002-922X
DOI
10.1001/archpedi.1970.02100050496007
Publisher site
See Article on Publisher Site

Abstract

Abstract Rectal activity patterns were obtained in 15 children with aganglionic megacolon by open-tipped catheter and were compared with 51 normal children. Bethanechol chloride (Urecholine) was given to six children with aganglionic megacolon and six well children without gastrointestinal complaints, and the responses were evaluated. An increased motor activity during resting periods and a heightened response to cholinergic stimulation with increased wave amplitude were demonstrated in the children with aganglionic megacolon. This evidence supports a concept of spastic contractility in the aganglionic segment of Hirschsprung's disease. References 1. Kamijo K, Hiatt RB, Koelle GB: Congenital megacolon: A comparison of the spastic and hypertrophied segments with respect to cholinesterase activities and sensitivities to acetylcholine: DFP and the barium ion . Gastroenterology 24:173-185, 1953. 2. Whitehouse FR, Kernohan JW: Myenteric plexus in congenital megacolon . Arch Intern Med 82:75-111, 1948.Crossref 3. Ehrenpreis T: Some newer aspects on Hirschsprung's disease and allied disorders . J Pediat Surg 1:329-337, 1966.Crossref 4. Swenson O, Rheinlander FH, Diamond I: Hirschsprung's disease: A new concept of the etiology . New Eng J Med 241:551-556, 1949.Crossref 5. Davidson M, Sleisenger HT, Steinberg H, et al: Studies of distal colonic motility in children: III. The pathologic physiology of congenital megacolon . Gastroenterology 29:803-823, 1955. 6. Hiatt RB: The pathologic physiology of congenital megacolon . Ann Surg 133:313-320, 1951.Crossref 7. Davidson M, Sleisenger MH, Almy TP, et al: Studies in distal colonic motility in children: I. Nonpropulsive patterns in normal children . Pediatrics 17:807-820, 1956. 8. Kim IC, Barbero GJ: The pattern of rectosigmoid motility in children . Gastroenterology 45: 57-66, 1963. 9. Code CF, Hightower NC Jr, Morlock CG: Motility of the alimentary canal in man: Review of recent studies . Amer J Med 13:328-351, 1952.Crossref 10. Cannon WB: A law of denervation . Amer J Med Sci 198:737-750, 1939.Crossref 11. Hope WJ, Borns FP, Berg KP: Roentgenologic manifestations of Hirschsprung's disease in infancy . Amer J Roentgen 95:217-229, 1965.Crossref 12. Tobon F, Reid NCRW, Talbert LJ, et al: Non-surgical test for the diagnosis of Hirschsprung's disease . New Eng J Med 278:188-194, 1968.Crossref 13. Ehrenpreis TH, Norberg KA, Wirsen C: Sympathetic innervation of the colon in Hirschsprung's disease: A histochemical study . J Pediat Surg 3:43-49, 1968.Crossref

Journal

American Journal of Diseases of ChildrenAmerican Medical Association

Published: Jun 1, 1970

References