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RECOVERY OF POLIOMYELITIS VIRUS FROM THE THROAT DURING THE INCUBATION PERIOD

RECOVERY OF POLIOMYELITIS VIRUS FROM THE THROAT DURING THE INCUBATION PERIOD Recovery of poliomyelitis virus from pharyngeal washings, tissues, and swabs of patients has been described repeatedly.1 Virus has also been recovered from similar sources in "healthy carriers."2 The early reports of this nature formed a basis for the hypothesis that the upper respiratory tract is the site of entrance and egress of virus. Studies in monkeys supported, by analogy, the theory that virus reached the central nervous system from the nasopharynx via the olfactory nerve.3 When histologic studies4 failed to supply evidence for passage of virus through the human olfactory bulb and newer methods allowed the ready demonstration of virus in stools,5 increased attention was directed to the alimentary canal. Although it became easier to demonstrate virus in stools than in nasopharyngeal washings, it was realized6 that the difference could be accounted for by longer persistence of virus in the stool (to the seventh http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA American Medical Association

RECOVERY OF POLIOMYELITIS VIRUS FROM THE THROAT DURING THE INCUBATION PERIOD

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References (26)

Publisher
American Medical Association
Copyright
Copyright © 1947 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
0098-7484
eISSN
1538-3598
DOI
10.1001/jama.1947.02890140004002
Publisher site
See Article on Publisher Site

Abstract

Recovery of poliomyelitis virus from pharyngeal washings, tissues, and swabs of patients has been described repeatedly.1 Virus has also been recovered from similar sources in "healthy carriers."2 The early reports of this nature formed a basis for the hypothesis that the upper respiratory tract is the site of entrance and egress of virus. Studies in monkeys supported, by analogy, the theory that virus reached the central nervous system from the nasopharynx via the olfactory nerve.3 When histologic studies4 failed to supply evidence for passage of virus through the human olfactory bulb and newer methods allowed the ready demonstration of virus in stools,5 increased attention was directed to the alimentary canal. Although it became easier to demonstrate virus in stools than in nasopharyngeal washings, it was realized6 that the difference could be accounted for by longer persistence of virus in the stool (to the seventh

Journal

JAMAAmerican Medical Association

Published: Dec 6, 1947

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