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PROGRESS IN PEDIATRICS RECENT CONTRIBUTIONS TO OUR KNOWLEDGE OF NEPHRITIS RICHARD M. M.D. SMITH, BOSTON PRODUCTION OF NEPHRITIS '11 ! Dickson1 has succeeded in a diffuse in chronic producing nephritis of and the administration uranium rabbits, dogs guinea-pigs by repeated nitrate. The resembled that found in man histologie picture closely for In the absence of demonstrable arterial lesions. except guinea-pigs was to acute death due an attack of accom¬ usually nephritis, frequently more or less anasarca. In the more severe cases there was panied by found also some of the left ventricle of the heart. usually hypertrophy O'Hare2 a chronic has also produced nephritis by injecting living colon bacilli cultures of into animals under the influence intravenously In of uranium nitrate. he on 40 excludes but all, rabbits, experimented from further consideration 22 which died after the first shortly injection. of of the chronic The 12 18 showed sufficient kidneys remaining change to the term chronic so "The lesions justify experimental pro¬ nephritis. are to duced similar those the renal tissues in chronic closely involving interstitial in man." of six rabbits The the nephritis kidneys remaining showed no found more than is in the normal animal. change frequently Christian
American journal of diseases of children – American Medical Association
Published: May 1, 1914
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