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Rebooting Cancer Tissue Handling in the Sequencing Era

Rebooting Cancer Tissue Handling in the Sequencing Era VIEWPOINT Rebooting Cancer Tissue Handling in the Sequencing Era Toward Routine Use of Frozen Tumor Tissue nomic changes occur in many solid adult tumors, and in Laura Goetz, MD, MPH many patients, the critical driver mutations and biologic path- Kelly Bethel, MD ways can be determined. Discovering this level of crucial Eric J. Topol, MD detail is possible only with whole genome and exome se- quencing of frozen tissue. ENOMICS IS POISED TO REVOLUTIONIZE CANCER TREAT- Obtaining Tissue: Noninvasive Equals ment. Whole genome sequencing is becoming more Noninformative? rapid, accurate, and affordable, and the ability to Guse genomic data to match biologically based Procuring frozen tissue for comprehensive genomic analy- therapy to an individual is becoming a reality. As the sequenc- sis requires adding an extra step to the established process ing endeavor transitions from a heroic effort performed by a of formalin fixation and also may require obtaining extra dedicated team for a particular patient to a routine compo- tissue (BOX). This is a significant concern in today’s world nent of most, if not all, cancer diagnoses, standards for ac- of less invasive procedures retrieving smaller and smaller quiring appropriate tissue samples also must evolve. This is amounts http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA American Medical Association

Rebooting Cancer Tissue Handling in the Sequencing Era

JAMA , Volume 309 (1) – Jan 2, 2013

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Publisher
American Medical Association
Copyright
Copyright 2013 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
0098-7484
eISSN
1538-3598
DOI
10.1001/jama.2012.70832
pmid
23280221
Publisher site
See Article on Publisher Site

Abstract

VIEWPOINT Rebooting Cancer Tissue Handling in the Sequencing Era Toward Routine Use of Frozen Tumor Tissue nomic changes occur in many solid adult tumors, and in Laura Goetz, MD, MPH many patients, the critical driver mutations and biologic path- Kelly Bethel, MD ways can be determined. Discovering this level of crucial Eric J. Topol, MD detail is possible only with whole genome and exome se- quencing of frozen tissue. ENOMICS IS POISED TO REVOLUTIONIZE CANCER TREAT- Obtaining Tissue: Noninvasive Equals ment. Whole genome sequencing is becoming more Noninformative? rapid, accurate, and affordable, and the ability to Guse genomic data to match biologically based Procuring frozen tissue for comprehensive genomic analy- therapy to an individual is becoming a reality. As the sequenc- sis requires adding an extra step to the established process ing endeavor transitions from a heroic effort performed by a of formalin fixation and also may require obtaining extra dedicated team for a particular patient to a routine compo- tissue (BOX). This is a significant concern in today’s world nent of most, if not all, cancer diagnoses, standards for ac- of less invasive procedures retrieving smaller and smaller quiring appropriate tissue samples also must evolve. This is amounts

Journal

JAMAAmerican Medical Association

Published: Jan 2, 2013

References