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A. Tatum, G. Cooper (1932)
META-AMINO PARA-HYDROXY PHENYL ARSINE OXIDE AS AN ANTISYPHILITIC AGENT.Science, 75 1951
A. L. Tatum (1934)
Experimental Study of Mapharsen (Meta-Amino Para-Hydroxy Phenyl Arsine Oxide) as Antisyphilitic AgentJ. Pharmacol. & Exper. Therap., 50
J. W. Jordon (1935)
Observations on Arsphenamine Dermatitis, with Special Reference to Reliability of Patch TestNew York State J. Med., 35
H. Cole, J. Moore, P. O’leary, J. Stokes, U. Wile, T. Clark, T. Parran, L. Usilton (1933)
Cooperative Clinical Studies in the Treatment of Syphilis-Arsenical Reactions.Venereal Disease Information, 14
O. H. Foerster , R. L. McIntosh, L. M. Wieder, H. R. Foerster (1935)
Mapharsen in Treatment of Syphilis: Preliminary ReportArch. Dermat. & Syph., 32
U. J. Wile (1934)
Study of Jaundice in Syphilis: Its Relation to TherapyAm. J. M. Sc., 187
O. Gruhzit, W. Lindsay, G. Hendricks, M. Dodd (1935)
MAPHARSEN (ARSENOXIDE) IN THE THERAPY OF EXPERIMENTAL SYPHILIS AND TRYPANOSOMIASISArchives of Dermatology, 32
P. Ehrlich (1910)
Die experimentelle Chemotherapie der Spirollosen
J. E. Moore , S. M. Hardy, H. M. Robinson (1936)
The Response of the Quantitatively Titered Wassermann Test in Early Syphilis to Treatment with Five Different Arsenical DrugsAm. J. Syph., Gonor. & Ven. Dis., 20
J. Moore (1934)
The modern treatment of syphilisThe American Journal of the Medical Sciences, 187
G. Kulchar, C. Barnett (1936)
Mapharsen in the Treatment of Early Syphilis.American Journal of Syphilis, 20
G. W. Raiziss (1935)
Comparative Chemotherapeutic Studies of "Arsenoxide" (3-Amino-4-Hydroxy-Phenyl-Arsenoxide) and NeoarsphenamineAm. J. Syph. & Neurol., 19
O. Gruhzit, R. Dixon, William McALONAN, W. Sherman, K. Merriman, G. Sewell, E. Arnold, P. Dowling, M. Pierson, E. Chambers, F. Lauppe (1936)
MAPHARSEN IN MASS TREATMENT OF SYPHILIS IN A CLINIC FOR VENEREAL DISEASESArchives of Dermatology, 34
Abstract Recently Tatum and Cooper1 reinvestigated a drug (metaaminoparahydroxyphenylarsine oxide) which they named mapharsen. This drug had originally been studied by Ehrlich and Hata,2 who expressed the belief that it was too toxic for use in the treatment of human syphilis. Tatum and Cooper, however, found that the "sterilizing therapeutic index" in rabbit syphilis was higher with mapharsen than with neoarsphenamine (1.66 compared with 1.11) and that doses of a given quantity of mapharsen produced results equal to those obtained by from thirty to fifty times as much neoarsphenamine. Raiziss and Severac3 later disagreed with Tatum and Cooper, stating that the "therapeutic index" given by the latter authors for neoarsphenamine in rabbit syphilis was too low. Raiziss and Severac pointed out that most investigators found neoarsphenamine to have a therapeutic index of about 5. They studied the effects of mapharsen and neoarsphenamine in rabbit syphilis and determined a References 1. Tatum, A. L., and Cooper, G. A.: Experimental Study of Mapharsen (Meta-Amino Para-Hydroxy Phenyl Arsine Oxide) as Antisyphilitic Agent , J. Pharmacol. & Exper. Therap. 50:198-215 ( (Feb.) ) 1934. 2. Ehrlich, P., and Hata, S.: Die experimentelle Chemotherapie der Spirollosen , Berlin, Julius Springer, 1910. 3. Raiziss, G. W., and Severac, M.: Comparative Chemotherapeutic Studies of "Arsenoxide" (3-Amino-4-Hydroxy-Phenyl-Arsenoxide) and Neoarsphenamine , Am. J. Syph. & Neurol. 19:473-480 ( (Oct.) ) 1935. 4. Gruhzit, O. M.: Mapharsen ("Arsenoxide") in Therapy of Experimental Syphilis and Trypanosomiasis , Arch. Dermat. & Syph. 32:848-867 ( (Dec.) ) 1935. 5. Foerster, O. H.; McIntosh, R. L.; Wieder, L. M.; Foerster, H. R., and Cooper, G. A.: Mapharsen in Treatment of Syphilis: Preliminary Report , Arch. Dermat. & Syph. 32:868-892 ( (Dec.) ) 1935. 6. Kulchar, G. V., and Barnett, C. W.: Mapharsen in the Treatment of Early Syphilis , Am. J. Syph., Gonor. & Ven. Dis. 20:482-486 ( (Sept.) ) 1936. 7. Moore, J. E.; Hardy, S. M.; Robinson, H. M., and Eagle, H.: The Response of the Quantitatively Titered Wassermann Test in Early Syphilis to Treatment with Five Different Arsenical Drugs , Am. J. Syph., Gonor. & Ven. Dis. 20:503-514 ( (Sept.) ) 1936. 8. Gruhzit, O. M., and Dixon, R. S.: Mapharsen in Mass Treatment of Syphilis in a Clinic for Venereal Diseases , Arch. Dermat. & Syph. 34:432-454 ( (Sept.) ) 1936. 9. Jordon, J. W., and Osborne, E. D.: Observations on Arsphenamine Dermatitis, with Special Reference to Reliability of Patch Test , New York State J. Med. 35:210-215 ( (March 1) ) 1935. 10. Cole, H. N., and others: Cooperative Clinical Studies in the Treatment of Syphilis: Arsenical Reactions , Ven. Dis. Inform. 14:173-200 ( (Aug.) ) 1933. 11. Moore, J. E.: The Modern Treatment of Syphilis , Springfield, Ill., Charles C. Thomas, Publisher, 1933. 12. Wile, U. J., and Sams, W. M.: Study of Jaundice in Syphilis: Its Relation to Therapy , Am. J. M. Sc. 187:297-315 ( (March) ) 1934.
Archives of Dermatology and Syphilology – American Medical Association
Published: Dec 1, 1937
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