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REACTIONS TO MAPHARSEN: WITH SPECIAL REFERENCE TO ITS USE IN PATIENTS WHO REACT TO THE ARSPHENAMINES

REACTIONS TO MAPHARSEN: WITH SPECIAL REFERENCE TO ITS USE IN PATIENTS WHO REACT TO THE ARSPHENAMINES Abstract Recently Tatum and Cooper1 reinvestigated a drug (metaaminoparahydroxyphenylarsine oxide) which they named mapharsen. This drug had originally been studied by Ehrlich and Hata,2 who expressed the belief that it was too toxic for use in the treatment of human syphilis. Tatum and Cooper, however, found that the "sterilizing therapeutic index" in rabbit syphilis was higher with mapharsen than with neoarsphenamine (1.66 compared with 1.11) and that doses of a given quantity of mapharsen produced results equal to those obtained by from thirty to fifty times as much neoarsphenamine. Raiziss and Severac3 later disagreed with Tatum and Cooper, stating that the "therapeutic index" given by the latter authors for neoarsphenamine in rabbit syphilis was too low. Raiziss and Severac pointed out that most investigators found neoarsphenamine to have a therapeutic index of about 5. They studied the effects of mapharsen and neoarsphenamine in rabbit syphilis and determined a References 1. Tatum, A. L., and Cooper, G. A.: Experimental Study of Mapharsen (Meta-Amino Para-Hydroxy Phenyl Arsine Oxide) as Antisyphilitic Agent , J. Pharmacol. & Exper. Therap. 50:198-215 ( (Feb.) ) 1934. 2. Ehrlich, P., and Hata, S.: Die experimentelle Chemotherapie der Spirollosen , Berlin, Julius Springer, 1910. 3. Raiziss, G. W., and Severac, M.: Comparative Chemotherapeutic Studies of "Arsenoxide" (3-Amino-4-Hydroxy-Phenyl-Arsenoxide) and Neoarsphenamine , Am. J. Syph. & Neurol. 19:473-480 ( (Oct.) ) 1935. 4. Gruhzit, O. M.: Mapharsen ("Arsenoxide") in Therapy of Experimental Syphilis and Trypanosomiasis , Arch. Dermat. & Syph. 32:848-867 ( (Dec.) ) 1935. 5. Foerster, O. H.; McIntosh, R. L.; Wieder, L. M.; Foerster, H. R., and Cooper, G. A.: Mapharsen in Treatment of Syphilis: Preliminary Report , Arch. Dermat. & Syph. 32:868-892 ( (Dec.) ) 1935. 6. Kulchar, G. V., and Barnett, C. W.: Mapharsen in the Treatment of Early Syphilis , Am. J. Syph., Gonor. & Ven. Dis. 20:482-486 ( (Sept.) ) 1936. 7. Moore, J. E.; Hardy, S. M.; Robinson, H. M., and Eagle, H.: The Response of the Quantitatively Titered Wassermann Test in Early Syphilis to Treatment with Five Different Arsenical Drugs , Am. J. Syph., Gonor. & Ven. Dis. 20:503-514 ( (Sept.) ) 1936. 8. Gruhzit, O. M., and Dixon, R. S.: Mapharsen in Mass Treatment of Syphilis in a Clinic for Venereal Diseases , Arch. Dermat. & Syph. 34:432-454 ( (Sept.) ) 1936. 9. Jordon, J. W., and Osborne, E. D.: Observations on Arsphenamine Dermatitis, with Special Reference to Reliability of Patch Test , New York State J. Med. 35:210-215 ( (March 1) ) 1935. 10. Cole, H. N., and others: Cooperative Clinical Studies in the Treatment of Syphilis: Arsenical Reactions , Ven. Dis. Inform. 14:173-200 ( (Aug.) ) 1933. 11. Moore, J. E.: The Modern Treatment of Syphilis , Springfield, Ill., Charles C. Thomas, Publisher, 1933. 12. Wile, U. J., and Sams, W. M.: Study of Jaundice in Syphilis: Its Relation to Therapy , Am. J. M. Sc. 187:297-315 ( (March) ) 1934. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Dermatology and Syphilology American Medical Association

REACTIONS TO MAPHARSEN: WITH SPECIAL REFERENCE TO ITS USE IN PATIENTS WHO REACT TO THE ARSPHENAMINES

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References (13)

Publisher
American Medical Association
Copyright
Copyright © 1937 American Medical Association. All Rights Reserved.
ISSN
0096-6029
DOI
10.1001/archderm.1937.01480060031004
Publisher site
See Article on Publisher Site

Abstract

Abstract Recently Tatum and Cooper1 reinvestigated a drug (metaaminoparahydroxyphenylarsine oxide) which they named mapharsen. This drug had originally been studied by Ehrlich and Hata,2 who expressed the belief that it was too toxic for use in the treatment of human syphilis. Tatum and Cooper, however, found that the "sterilizing therapeutic index" in rabbit syphilis was higher with mapharsen than with neoarsphenamine (1.66 compared with 1.11) and that doses of a given quantity of mapharsen produced results equal to those obtained by from thirty to fifty times as much neoarsphenamine. Raiziss and Severac3 later disagreed with Tatum and Cooper, stating that the "therapeutic index" given by the latter authors for neoarsphenamine in rabbit syphilis was too low. Raiziss and Severac pointed out that most investigators found neoarsphenamine to have a therapeutic index of about 5. They studied the effects of mapharsen and neoarsphenamine in rabbit syphilis and determined a References 1. Tatum, A. L., and Cooper, G. A.: Experimental Study of Mapharsen (Meta-Amino Para-Hydroxy Phenyl Arsine Oxide) as Antisyphilitic Agent , J. Pharmacol. & Exper. Therap. 50:198-215 ( (Feb.) ) 1934. 2. Ehrlich, P., and Hata, S.: Die experimentelle Chemotherapie der Spirollosen , Berlin, Julius Springer, 1910. 3. Raiziss, G. W., and Severac, M.: Comparative Chemotherapeutic Studies of "Arsenoxide" (3-Amino-4-Hydroxy-Phenyl-Arsenoxide) and Neoarsphenamine , Am. J. Syph. & Neurol. 19:473-480 ( (Oct.) ) 1935. 4. Gruhzit, O. M.: Mapharsen ("Arsenoxide") in Therapy of Experimental Syphilis and Trypanosomiasis , Arch. Dermat. & Syph. 32:848-867 ( (Dec.) ) 1935. 5. Foerster, O. H.; McIntosh, R. L.; Wieder, L. M.; Foerster, H. R., and Cooper, G. A.: Mapharsen in Treatment of Syphilis: Preliminary Report , Arch. Dermat. & Syph. 32:868-892 ( (Dec.) ) 1935. 6. Kulchar, G. V., and Barnett, C. W.: Mapharsen in the Treatment of Early Syphilis , Am. J. Syph., Gonor. & Ven. Dis. 20:482-486 ( (Sept.) ) 1936. 7. Moore, J. E.; Hardy, S. M.; Robinson, H. M., and Eagle, H.: The Response of the Quantitatively Titered Wassermann Test in Early Syphilis to Treatment with Five Different Arsenical Drugs , Am. J. Syph., Gonor. & Ven. Dis. 20:503-514 ( (Sept.) ) 1936. 8. Gruhzit, O. M., and Dixon, R. S.: Mapharsen in Mass Treatment of Syphilis in a Clinic for Venereal Diseases , Arch. Dermat. & Syph. 34:432-454 ( (Sept.) ) 1936. 9. Jordon, J. W., and Osborne, E. D.: Observations on Arsphenamine Dermatitis, with Special Reference to Reliability of Patch Test , New York State J. Med. 35:210-215 ( (March 1) ) 1935. 10. Cole, H. N., and others: Cooperative Clinical Studies in the Treatment of Syphilis: Arsenical Reactions , Ven. Dis. Inform. 14:173-200 ( (Aug.) ) 1933. 11. Moore, J. E.: The Modern Treatment of Syphilis , Springfield, Ill., Charles C. Thomas, Publisher, 1933. 12. Wile, U. J., and Sams, W. M.: Study of Jaundice in Syphilis: Its Relation to Therapy , Am. J. M. Sc. 187:297-315 ( (March) ) 1934.

Journal

Archives of Dermatology and SyphilologyAmerican Medical Association

Published: Dec 1, 1937

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