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Rat Salivary Glands After Long-Term Isoproterenol Administration

Rat Salivary Glands After Long-Term Isoproterenol Administration Abstract The pathogenesis of human salivary gland tumors and stones remains an enigma. Presently used model systems are not valid in light of known epidemiologic data. A large literature exists concerning the effects of the autonomic nervous system on salivary gland anatomy and physiology. The present study was undertaken to see if stones or tumors could be induced In the salivary glands of rats subjected to long-term parenteral administration of isoproterenol. One-micron and electron microscopic evaluation demonstrated reversible acinar hyperplasia. No stones or tumors were found, even with the added stimulus of cyclophosphamide. References 1. Selye H, Veilleux R, Cantin M: Excessive stimulation of salivary gland growth by isoproterenol . Science 133:44-45, 1961.Crossref 2. Selye H, Cantin M, Veilleux R: Abnormal growth and sclerosis of the salivary glands induced by chronic treatment with isoproterenol . Growth 25:243-248, 1961. 3. Mandel ID, Katz R: The effect of pharmacologic agents on salivary secretion and composition: II. Isoproterenol alpha and beta adrenergic blockers . J Oral Therap Pharmacol 4:260-269, 1968. 4. Zengo AN, et al: Chemistry of rat saliva following isoproterenol administration . J Oral Therap Pharmacol 4:359-363, 1968. 5. Schantz A, Schecter A: Iron-hematoxylin and safranin O as a polychrome stain for epon sections . Stain Technol 4:279-283, 1965. 6. Sevier AC: The use of oxone in staining osmium-fixed epoxy-embedded sections . Anat Rec 157:403, 1967. 7. Fisher DB: Protein staining of ribboned epon sections for light microscopy . Histochemie 16:92-96, 1968.Crossref 8. Pohto P: Studies on salivary gland hypertrophy induced in rats by isoprenaline . Acta Pharmacol Toxicol 21:45-50, 1964.Crossref 9. Barka T: Stimulation of deoxyribonucleic acid synthesis in salivary gland by isoproterenol . Exp Cell Res 48:53-60, 1967.Crossref 10. Barka T: Stimulation of protein and ribonucleic acid synthesis in rat submaxillary gland by isoproterenol . Lab Invest 18:38-41, 1968. 11. Kirby KC Jr, Swern D, Baserga R: The effect of structural modifications of the isoproterenol molecule on the stimulation of deoxyribonucleic acid synthesis in mouse salivary glands . Mol Pharmacol 5:572-579, 1969. 12. Houssay AB, et al: Accion del isoproterenol en glandulas salivares normales y patologicas . Rev Asoc Odont Argent 53:299-306, 1965. 13. Novi AM, Baserga R: Association of hypertrophy and DNA synthesis in mouse salivary glands after chronic administration of isoproterenol . Am J Pathol 62:295-308, 1971. 14. Radley JM: Changes in ploidy in the rat submaxillary gland induced by isoprenaline . Exp Cell Res 48:679-681, 1967.Crossref 15. Ershoff E, Bajura C: Submaxillary gland hypertrophy in rats fed proteolytic enzymes . Proc Soc Exp Biol Med 113:879-881, 1963.Crossref 16. Wells H, Handelman C, Milgram E: Regulation by sympathetic nervous system of accelerated growth of salivary glands of rats . Am J Physiol 201:707-710, 1961. 17. Brenner GM, Stanton HC: Adrenergic mechanisms responsible for submandibular salivary glandular hypertrophy in the rat . J Pharmacol Exp Ther 173:166-175, 1970. 18. Emmelin N, Holmberg J, Ohlin P: Receptors for catecholamines in the submaxillary glands of rats . Br J Pharmacol Chemother 25:134-138, 1965.Crossref 19. Holmberg J: Action of new beta blocking agents on the submaxillary gland of the rat . Experentia 23:734-735, 1967.Crossref 20. Yoshida Y, et al: Role of beta receptors in sympathetic regulation of electrolytes in rat submaxillary saliva . Proc Soc Exp Biol Med 126:912-916, 1967.Crossref 21. Brusilow SW, Cook RW: Role of parotid ducts in secretion of hypotonic saliva . Am J Physiol 196:831-834, 1959. 22. Mangos JA, Braun G, Hammann KF: Micropuncture study of sodium and potassium excretion in the rat parotid saliva . Arch Ges Physiol 291:99-106, 1966.Crossref 23. Mangos JA, McSherry NR: Micropuncture study of sodium and potassium excretion in rat parotid saliva: Role of aldosterone . Proc Soc Exp Biol Med 132:797-801, 1969.Crossref 24. Norberg KA, Eneroth C-M, Hokfelt T: The significance of the autonomic innervation for the salivary secretion in the human parotid and submandibular glands . Acta Otolaryngol 263:193-194, 1970.Crossref 25. Lowenstein C: Uber atypische epithelwucherungen und tumoren der speicheldrusen, besonders der parotis . Z Pathol 4:187-202, 1910. 26. Bauer WH, Byrne JJ: Induced tumors of the parotid gland . Cancer Res 10:755-761, 1950. 27. Cataldo E, Shklar G, Chauncey HH: Experimental submaxillary gland tumors in rats . Arch Pathol 77:305-316, 1964. 28. Shklar G, Cataldo E: Effects of a chemical carcinogen on the submaxillary gland of albino rats treated with isoproterenol . Cancer Res 26:1319-1323, 1966. 29. Sheehan R, Shklar G: The effect of cyclophosphamide on experimental salivary gland neoplasia . Cancer Res 32:420-425, 1972. 30. Cowdry EV: Etiology and Prevention of Cancer in Man . New York, Appleton-Century Crofts, 1968. 31. Rowe NH, et al: Proceedings of the Fourth International Academy of Oral Pathology . New York, Gordon & Breach Scientific Publications Inc, 1970. 32. Rowe NH, et al: A study of environmental influence upon salivary gland neoplasia in rats . Cancer 26:436-444, 1970.Crossref 33. McLaren DS: Biochemical and hematologic changes in the vitamin A deficient rat . Am J Clin Nutr 17:131-138, 1965. 34. Nielson SW, et al: Parotid duct metaplasia in marginal bovine vitamin A deficiency . Am J Vet Res 27:223-233, 1966. 35. Lawrence DJ, Bern HA: Mucous metaplasia and mucous gland formation in keratinized adult epithelium in-situ treated with vitamin A . Exp Cell Res 21:443-446, 1960.Crossref 36. Orr IM: Oral cancer in betel nut chewers in Travancore . Lancet 2:575-580, 1963. 37. Wahi PN, Kehar U, Lahiri B: Factors influencing oral and oropharyngeal cancers in India . Br J Cancer 19:642-660, 1965.Crossref 38. Saffioti U, et al: Experimental cancer of the lung inhibition by vitamin A of the induction of tracheobronchial squamous metaplasia and squamous cell tumors . Cancer 20:857-864, 1967.Crossref 39. Hitchcock CR: Attempts to Abet the Action of Methylcholanthracene in the Induction of Gastric Cancers in Mice, Using Dietary Deficiencies, thesis. Department of Surgery of the Graduate School, University of Minnesota, Minneapolis, 1954. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Otolaryngology American Medical Association

Rat Salivary Glands After Long-Term Isoproterenol Administration

Archives of Otolaryngology , Volume 100 (4) – Oct 1, 1974

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Publisher
American Medical Association
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Copyright © 1974 American Medical Association. All Rights Reserved.
ISSN
0003-9977
DOI
10.1001/archotol.1974.00780040266003
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Abstract

Abstract The pathogenesis of human salivary gland tumors and stones remains an enigma. Presently used model systems are not valid in light of known epidemiologic data. A large literature exists concerning the effects of the autonomic nervous system on salivary gland anatomy and physiology. The present study was undertaken to see if stones or tumors could be induced In the salivary glands of rats subjected to long-term parenteral administration of isoproterenol. One-micron and electron microscopic evaluation demonstrated reversible acinar hyperplasia. No stones or tumors were found, even with the added stimulus of cyclophosphamide. References 1. Selye H, Veilleux R, Cantin M: Excessive stimulation of salivary gland growth by isoproterenol . Science 133:44-45, 1961.Crossref 2. Selye H, Cantin M, Veilleux R: Abnormal growth and sclerosis of the salivary glands induced by chronic treatment with isoproterenol . Growth 25:243-248, 1961. 3. Mandel ID, Katz R: The effect of pharmacologic agents on salivary secretion and composition: II. Isoproterenol alpha and beta adrenergic blockers . J Oral Therap Pharmacol 4:260-269, 1968. 4. Zengo AN, et al: Chemistry of rat saliva following isoproterenol administration . J Oral Therap Pharmacol 4:359-363, 1968. 5. Schantz A, Schecter A: Iron-hematoxylin and safranin O as a polychrome stain for epon sections . Stain Technol 4:279-283, 1965. 6. Sevier AC: The use of oxone in staining osmium-fixed epoxy-embedded sections . Anat Rec 157:403, 1967. 7. Fisher DB: Protein staining of ribboned epon sections for light microscopy . Histochemie 16:92-96, 1968.Crossref 8. Pohto P: Studies on salivary gland hypertrophy induced in rats by isoprenaline . Acta Pharmacol Toxicol 21:45-50, 1964.Crossref 9. Barka T: Stimulation of deoxyribonucleic acid synthesis in salivary gland by isoproterenol . Exp Cell Res 48:53-60, 1967.Crossref 10. Barka T: Stimulation of protein and ribonucleic acid synthesis in rat submaxillary gland by isoproterenol . Lab Invest 18:38-41, 1968. 11. Kirby KC Jr, Swern D, Baserga R: The effect of structural modifications of the isoproterenol molecule on the stimulation of deoxyribonucleic acid synthesis in mouse salivary glands . Mol Pharmacol 5:572-579, 1969. 12. Houssay AB, et al: Accion del isoproterenol en glandulas salivares normales y patologicas . Rev Asoc Odont Argent 53:299-306, 1965. 13. Novi AM, Baserga R: Association of hypertrophy and DNA synthesis in mouse salivary glands after chronic administration of isoproterenol . Am J Pathol 62:295-308, 1971. 14. Radley JM: Changes in ploidy in the rat submaxillary gland induced by isoprenaline . Exp Cell Res 48:679-681, 1967.Crossref 15. Ershoff E, Bajura C: Submaxillary gland hypertrophy in rats fed proteolytic enzymes . Proc Soc Exp Biol Med 113:879-881, 1963.Crossref 16. Wells H, Handelman C, Milgram E: Regulation by sympathetic nervous system of accelerated growth of salivary glands of rats . Am J Physiol 201:707-710, 1961. 17. Brenner GM, Stanton HC: Adrenergic mechanisms responsible for submandibular salivary glandular hypertrophy in the rat . J Pharmacol Exp Ther 173:166-175, 1970. 18. Emmelin N, Holmberg J, Ohlin P: Receptors for catecholamines in the submaxillary glands of rats . Br J Pharmacol Chemother 25:134-138, 1965.Crossref 19. Holmberg J: Action of new beta blocking agents on the submaxillary gland of the rat . Experentia 23:734-735, 1967.Crossref 20. Yoshida Y, et al: Role of beta receptors in sympathetic regulation of electrolytes in rat submaxillary saliva . Proc Soc Exp Biol Med 126:912-916, 1967.Crossref 21. Brusilow SW, Cook RW: Role of parotid ducts in secretion of hypotonic saliva . Am J Physiol 196:831-834, 1959. 22. Mangos JA, Braun G, Hammann KF: Micropuncture study of sodium and potassium excretion in the rat parotid saliva . Arch Ges Physiol 291:99-106, 1966.Crossref 23. Mangos JA, McSherry NR: Micropuncture study of sodium and potassium excretion in rat parotid saliva: Role of aldosterone . Proc Soc Exp Biol Med 132:797-801, 1969.Crossref 24. Norberg KA, Eneroth C-M, Hokfelt T: The significance of the autonomic innervation for the salivary secretion in the human parotid and submandibular glands . Acta Otolaryngol 263:193-194, 1970.Crossref 25. Lowenstein C: Uber atypische epithelwucherungen und tumoren der speicheldrusen, besonders der parotis . Z Pathol 4:187-202, 1910. 26. Bauer WH, Byrne JJ: Induced tumors of the parotid gland . Cancer Res 10:755-761, 1950. 27. Cataldo E, Shklar G, Chauncey HH: Experimental submaxillary gland tumors in rats . Arch Pathol 77:305-316, 1964. 28. Shklar G, Cataldo E: Effects of a chemical carcinogen on the submaxillary gland of albino rats treated with isoproterenol . Cancer Res 26:1319-1323, 1966. 29. Sheehan R, Shklar G: The effect of cyclophosphamide on experimental salivary gland neoplasia . Cancer Res 32:420-425, 1972. 30. Cowdry EV: Etiology and Prevention of Cancer in Man . New York, Appleton-Century Crofts, 1968. 31. Rowe NH, et al: Proceedings of the Fourth International Academy of Oral Pathology . New York, Gordon & Breach Scientific Publications Inc, 1970. 32. Rowe NH, et al: A study of environmental influence upon salivary gland neoplasia in rats . Cancer 26:436-444, 1970.Crossref 33. McLaren DS: Biochemical and hematologic changes in the vitamin A deficient rat . Am J Clin Nutr 17:131-138, 1965. 34. Nielson SW, et al: Parotid duct metaplasia in marginal bovine vitamin A deficiency . Am J Vet Res 27:223-233, 1966. 35. Lawrence DJ, Bern HA: Mucous metaplasia and mucous gland formation in keratinized adult epithelium in-situ treated with vitamin A . Exp Cell Res 21:443-446, 1960.Crossref 36. Orr IM: Oral cancer in betel nut chewers in Travancore . Lancet 2:575-580, 1963. 37. Wahi PN, Kehar U, Lahiri B: Factors influencing oral and oropharyngeal cancers in India . Br J Cancer 19:642-660, 1965.Crossref 38. Saffioti U, et al: Experimental cancer of the lung inhibition by vitamin A of the induction of tracheobronchial squamous metaplasia and squamous cell tumors . Cancer 20:857-864, 1967.Crossref 39. Hitchcock CR: Attempts to Abet the Action of Methylcholanthracene in the Induction of Gastric Cancers in Mice, Using Dietary Deficiencies, thesis. Department of Surgery of the Graduate School, University of Minnesota, Minneapolis, 1954.

Journal

Archives of OtolaryngologyAmerican Medical Association

Published: Oct 1, 1974

References