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RAPID DETERMINATION OF OPTIMUM MEDICATION IN RECALCITRANT CASES OF EPILEPSY

RAPID DETERMINATION OF OPTIMUM MEDICATION IN RECALCITRANT CASES OF EPILEPSY Abstract SINCE THE development of the conception of specific anticonvulsant drugs and of methods of testing anticonvulsant activity in animals1 a long list of new medicines has been introduced into clinical practice for the control of epilepsy. It includes diphenylhydantoin U. S. P. (phenytoin, Dilantin), methylphenylethylhydantoin (Mesantoin), phenacemide (Phenurone), trimethadione U. S. P. (Tridione), paramethadione (Paradione), phethenylate (Thiantoin), and glutamic acid. Others not yet on the market are under investigation, and of course phenobarbital is still a strong contender. Almost alone among recent authors, Arieff2 maintains 12% of his patients on bromides, and 73% are seizure-free. Even the ketogenic diet is still used,3 and interest in the use of surgical measures has widened.4 The practitioner, and even the specialist, is apt to find himself confused by this plethora, and reference to the literature is not particularly helpful. Usually an investigator who wishes to try a new drug References 1. References 8 and 9. 2. References 20 and 21. 3. References 26 and 27. 4. Putnam, T. J., and Merritt, H. H.: Experimental Determination of the Anticonvulsant Properties of Some Phenyl Derivatives , Science 85:525-526 ( (May 28) ) 1937.Crossref 5. Arieff, A. J.: Twelve-Year Résumé in a Clinic for Epilepsy , Dis. Nerv. System 12:19-22 ( (Jan.) ) 1951. 6. Keith, H. M.: Results of Treatment of Recurring Convulsive Attacks of Epilepsy , Am. J. Dis. Child. 74:140-146 ( (Aug.) ) 1947. 7. Bailey, P., and Gibbs, F. A.: Surgical Treatment of Psychomotor Epilepsy , J. A. M. A. 145:365-370 ( (Feb. 10) ) 1951.Crossref 8. Locock, C.: Discussion on Sieveking, E. H.: Analysis of 52 Cases of Epilepsy Observed by the Author , Lancet 1:528, 1857. 9. Pollock, L. J.: Remissions of Attacks in Epilepsy Treated with Sodium Bromide , J. A. M. A. 110:632-634 ( (Feb. 26) ) 1938.Crossref 10. Lennox, W. G.: Pharmacopeia and the Physician: Drug Therapy of Epilepsy , J. A. M. A. 114:1347-1354 ( (April 6) ) 1940. 11. Merritt, H. H., and Putnam, T. J.: Sodium Diphenyl Hydantoinate in the Treatment of Convulsive Disorders , J. A. M. A. 111:1068-1073 ( (Sept. 17) ) 1938.Crossref 12. Merritt, H. H., and Putnam, T. J.: Further Experiences with the Use of Sodium Diphenyl Hydantoinate in the Treatment of Convulsive Disorders , Am. J. Psychiat. 96:1023-1027 ( (March) ) 1940. 13. Kozol, H. L.: Mesantoin in the Treatment of Epilepsy: Report on 200 Patients Under Treatment for Periods Ranging from 2 Months to 4 Years , Arch. Neurol. & Psychiat. 63:235-248 ( (Feb.) ) 1950. 14. Lennox, W. G.: Petit Mal Epilepsies: Their Treatment with Tridione , J. A. M. A. 129:1069-1074 ( (Dec. 15) ) 1945. 15. Penfield, W., and Steelman, H.: Treatment of Focal Epilepsy by Cortical Excision , Ann. Surg. 126:740-762 ( (Nov.) ) 1947. 16. Chaiken, B. H.; Goldberg, B. I., and Segal, J. P.: Dilantin Sensitivity: Report of a Case of Hepatitis with Jaundice, Pyrexia and Exfoliative Dermatitis , New England J. Med. 242:897-898 ( (June 8) ) 1950. 17. Hambourger, W. E.: Study of Promiscuous Use of the Barbiturates: Their Use in Suicides , J. A. M. A. 112:1340-1343 ( (April 8) ) 1939. 18. Abbott, J. A., and Schwab, R. S.: Serious Side Effects of the Newer Antiepileptic Drugs: Their Control and Prevention , New England J. Med. 242:943-949 ( (June 15) ) 1950. 19. Putnam, T. J.: On the Nature and Treatment of Epilepsy , Connecticut M. J. 5:257-260 ( (April) ) 1941. 20. Yahr, M. D.; Sciarra, D.; Carter, S., and Merritt, H. H.: Evaluation of Standard Anticonvulsant Therapy in 319 Patients , J. A. M. A. 150:663-667 ( (Oct. 18) ) 1952. 21. Ziskin, D. E.; Stowe, L. R., and Zegarelli, E. V.: Dilantin Hyperplastic Gingivitis: Its Treatment and Prevention , Arch. Neurol. & Psychiat. 46:897-907 ( (Nov.) ) 1941. 22. Price, J. C.; Waelsch, H., and Putnam, T. J.: dl-Glutmic Acid Hydrochloride in Treatment of Petit Mal and Psychomotor Seizures , J. A. M. A. 122:1153-1156 ( (Aug. 21) ) 1943. 23. Putnam, T. J.: Hyperintensive Treatment of Epilepsy , Tr. Am. Neurol. A. 74:48-49, 1949. 24. Putnam, T. J., and Rothenberg, S. F.: Results of Intensive (Narcosis) and Standard Medical Treatment of Epilepsy , J. A. M. A. 152:1400-1406 ( (Aug. 8) ) 1953.Crossref 25. Gibbs, F. A.; Davis, H., and Lennox, W. G.: Electroencephalogram in Epilepsy and in Conditions of Impaired Consciousness , Arch. Neurol. & Psychiat. 34:1133-1148 ( (Dec.) ) 1935. 26. Lennox, W. G.; Gibbs, F. A., and Gibbs, E. L.: Effect on the Electroencephalogram of Drugs and Conditions Which Influence Seizures , Arch. Neurol. & Psychiat. 36:1236-1245 ( (Dec.) ) 1936. 27. Lennox, W. G.: Influence of Drugs on the Human Electroencephalogram , Electroencephalog. & Clin. Neurophysiol. 1:45-51 ( (Feb.) ) 1949. 28. Schwab, R. S.; Grunwald, A., and Sargant, W.: Regulation of the Treatment of Epilepsy by Synchronized Recording of Respiration and Brain Waves , Arch. Neurol. & Psychiat. 46:1017-1034 ( (Dec.) ) 1941. 29. Bercel, N. A., and Ziskind, E.: Comparative Efficacy of Anticonvulsants Studied with New Technique , Tr. Am. Neurol. A. 72:173-176, 1947. 30. Ziskind, E., and Bercel, N. A.: Preconvulsive Paroxysmal Electroencephalographic Changes After Metrazol Injections , J. Nerv. & Ment. Dis. 111:52-63 ( (Jan.) ) 1950. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png A.M.A. Archives of Neurology & Psychiatry American Medical Association

RAPID DETERMINATION OF OPTIMUM MEDICATION IN RECALCITRANT CASES OF EPILEPSY

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Publisher
American Medical Association
Copyright
Copyright © 1954 American Medical Association. All Rights Reserved.
ISSN
0096-6886
DOI
10.1001/archneurpsyc.1954.02330020037004
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Abstract

Abstract SINCE THE development of the conception of specific anticonvulsant drugs and of methods of testing anticonvulsant activity in animals1 a long list of new medicines has been introduced into clinical practice for the control of epilepsy. It includes diphenylhydantoin U. S. P. (phenytoin, Dilantin), methylphenylethylhydantoin (Mesantoin), phenacemide (Phenurone), trimethadione U. S. P. (Tridione), paramethadione (Paradione), phethenylate (Thiantoin), and glutamic acid. Others not yet on the market are under investigation, and of course phenobarbital is still a strong contender. Almost alone among recent authors, Arieff2 maintains 12% of his patients on bromides, and 73% are seizure-free. Even the ketogenic diet is still used,3 and interest in the use of surgical measures has widened.4 The practitioner, and even the specialist, is apt to find himself confused by this plethora, and reference to the literature is not particularly helpful. Usually an investigator who wishes to try a new drug References 1. References 8 and 9. 2. References 20 and 21. 3. References 26 and 27. 4. Putnam, T. J., and Merritt, H. H.: Experimental Determination of the Anticonvulsant Properties of Some Phenyl Derivatives , Science 85:525-526 ( (May 28) ) 1937.Crossref 5. Arieff, A. J.: Twelve-Year Résumé in a Clinic for Epilepsy , Dis. Nerv. System 12:19-22 ( (Jan.) ) 1951. 6. Keith, H. M.: Results of Treatment of Recurring Convulsive Attacks of Epilepsy , Am. J. Dis. Child. 74:140-146 ( (Aug.) ) 1947. 7. Bailey, P., and Gibbs, F. A.: Surgical Treatment of Psychomotor Epilepsy , J. A. M. A. 145:365-370 ( (Feb. 10) ) 1951.Crossref 8. Locock, C.: Discussion on Sieveking, E. H.: Analysis of 52 Cases of Epilepsy Observed by the Author , Lancet 1:528, 1857. 9. Pollock, L. J.: Remissions of Attacks in Epilepsy Treated with Sodium Bromide , J. A. M. A. 110:632-634 ( (Feb. 26) ) 1938.Crossref 10. Lennox, W. G.: Pharmacopeia and the Physician: Drug Therapy of Epilepsy , J. A. M. A. 114:1347-1354 ( (April 6) ) 1940. 11. Merritt, H. H., and Putnam, T. J.: Sodium Diphenyl Hydantoinate in the Treatment of Convulsive Disorders , J. A. M. A. 111:1068-1073 ( (Sept. 17) ) 1938.Crossref 12. Merritt, H. H., and Putnam, T. J.: Further Experiences with the Use of Sodium Diphenyl Hydantoinate in the Treatment of Convulsive Disorders , Am. J. Psychiat. 96:1023-1027 ( (March) ) 1940. 13. Kozol, H. L.: Mesantoin in the Treatment of Epilepsy: Report on 200 Patients Under Treatment for Periods Ranging from 2 Months to 4 Years , Arch. Neurol. & Psychiat. 63:235-248 ( (Feb.) ) 1950. 14. Lennox, W. G.: Petit Mal Epilepsies: Their Treatment with Tridione , J. A. M. A. 129:1069-1074 ( (Dec. 15) ) 1945. 15. Penfield, W., and Steelman, H.: Treatment of Focal Epilepsy by Cortical Excision , Ann. Surg. 126:740-762 ( (Nov.) ) 1947. 16. Chaiken, B. H.; Goldberg, B. I., and Segal, J. P.: Dilantin Sensitivity: Report of a Case of Hepatitis with Jaundice, Pyrexia and Exfoliative Dermatitis , New England J. Med. 242:897-898 ( (June 8) ) 1950. 17. Hambourger, W. E.: Study of Promiscuous Use of the Barbiturates: Their Use in Suicides , J. A. M. A. 112:1340-1343 ( (April 8) ) 1939. 18. Abbott, J. A., and Schwab, R. S.: Serious Side Effects of the Newer Antiepileptic Drugs: Their Control and Prevention , New England J. Med. 242:943-949 ( (June 15) ) 1950. 19. Putnam, T. J.: On the Nature and Treatment of Epilepsy , Connecticut M. J. 5:257-260 ( (April) ) 1941. 20. Yahr, M. D.; Sciarra, D.; Carter, S., and Merritt, H. H.: Evaluation of Standard Anticonvulsant Therapy in 319 Patients , J. A. M. A. 150:663-667 ( (Oct. 18) ) 1952. 21. Ziskin, D. E.; Stowe, L. R., and Zegarelli, E. V.: Dilantin Hyperplastic Gingivitis: Its Treatment and Prevention , Arch. Neurol. & Psychiat. 46:897-907 ( (Nov.) ) 1941. 22. Price, J. C.; Waelsch, H., and Putnam, T. J.: dl-Glutmic Acid Hydrochloride in Treatment of Petit Mal and Psychomotor Seizures , J. A. M. A. 122:1153-1156 ( (Aug. 21) ) 1943. 23. Putnam, T. J.: Hyperintensive Treatment of Epilepsy , Tr. Am. Neurol. A. 74:48-49, 1949. 24. Putnam, T. J., and Rothenberg, S. F.: Results of Intensive (Narcosis) and Standard Medical Treatment of Epilepsy , J. A. M. A. 152:1400-1406 ( (Aug. 8) ) 1953.Crossref 25. Gibbs, F. A.; Davis, H., and Lennox, W. G.: Electroencephalogram in Epilepsy and in Conditions of Impaired Consciousness , Arch. Neurol. & Psychiat. 34:1133-1148 ( (Dec.) ) 1935. 26. Lennox, W. G.; Gibbs, F. A., and Gibbs, E. L.: Effect on the Electroencephalogram of Drugs and Conditions Which Influence Seizures , Arch. Neurol. & Psychiat. 36:1236-1245 ( (Dec.) ) 1936. 27. Lennox, W. G.: Influence of Drugs on the Human Electroencephalogram , Electroencephalog. & Clin. Neurophysiol. 1:45-51 ( (Feb.) ) 1949. 28. Schwab, R. S.; Grunwald, A., and Sargant, W.: Regulation of the Treatment of Epilepsy by Synchronized Recording of Respiration and Brain Waves , Arch. Neurol. & Psychiat. 46:1017-1034 ( (Dec.) ) 1941. 29. Bercel, N. A., and Ziskind, E.: Comparative Efficacy of Anticonvulsants Studied with New Technique , Tr. Am. Neurol. A. 72:173-176, 1947. 30. Ziskind, E., and Bercel, N. A.: Preconvulsive Paroxysmal Electroencephalographic Changes After Metrazol Injections , J. Nerv. & Ment. Dis. 111:52-63 ( (Jan.) ) 1950.

Journal

A.M.A. Archives of Neurology & PsychiatryAmerican Medical Association

Published: Aug 1, 1954

References