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RADIOLOGIC SIGN IN HEMOSIDEROSIS

RADIOLOGIC SIGN IN HEMOSIDEROSIS Approximately 80 cases of exogenous hemosiderosis have been reported in the literature since 1948. This entity has been termed by various observers as iron overload, transfusional hemosiderosis, and secondary hemochromatosis.1 In a review of the literature on hemochromatosis and hemosiderosis we found few references to the x-ray findings in these conditions. Increased liver density, found by use of x-rays, has been reported in cases of hemochromatosis.2 Increased density of the spleen, however, has not been referred to previously. The occurrence of iron and calcium deposits in the spleen in patients with sickle cell anemia has previously been described.3 In idiopathic hemosiderosis, the iron is stored predominantly in the liver; in exogenous hemochromatosis, a greater amount of iron appears to be concentrated in the spleen.4 We were therefore not surprised that in some patients with transfusional hemosiderosis an increased density of the spleen could be seen on http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA American Medical Association

RADIOLOGIC SIGN IN HEMOSIDEROSIS

Shanbrom, Edward; Zheutlin, Norman
JAMA , Volume 168 (1) – Sep 6, 1958
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References (4)

Publisher
American Medical Association
Copyright
Copyright © 1958 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
0098-7484
eISSN
1538-3598
DOI
10.1001/jama.1958.63000010001008
Publisher site
See Article on Publisher Site

Abstract

Approximately 80 cases of exogenous hemosiderosis have been reported in the literature since 1948. This entity has been termed by various observers as iron overload, transfusional hemosiderosis, and secondary hemochromatosis.1 In a review of the literature on hemochromatosis and hemosiderosis we found few references to the x-ray findings in these conditions. Increased liver density, found by use of x-rays, has been reported in cases of hemochromatosis.2 Increased density of the spleen, however, has not been referred to previously. The occurrence of iron and calcium deposits in the spleen in patients with sickle cell anemia has previously been described.3 In idiopathic hemosiderosis, the iron is stored predominantly in the liver; in exogenous hemochromatosis, a greater amount of iron appears to be concentrated in the spleen.4 We were therefore not surprised that in some patients with transfusional hemosiderosis an increased density of the spleen could be seen on

Journal

JAMA – American Medical Association

Published: Sep 6, 1958

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