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Radiofrequency Ablation of Advanced Head and Neck Cancer

Radiofrequency Ablation of Advanced Head and Neck Cancer ORIGINAL ARTICLE Radiofrequency Ablation of Advanced Head and Neck Cancer Randall P. Owen, MD, MS; Sajid A. Khan, MD; Abdissa Negassa, PhD; Jonathan J. Beitler, MD, MBA; Jacqueline A. Bello, MD; Allan Brook, MD; Joaquim Farinhas, MD; Madhur K. Garg, MD; Missak Haigentz Jr, MD; Todd S. Miller, MD; Melody S. Hsu, MD; Thanjuvar S. Ravikumar, MD; Keivan Shifteh, MD; Richard V. Smith, MD; Carl E. Silver, MD Objective: To determine if the application of radiofre- Main Outcome Measures: The primary end point was quency ablation to advanced head and neck cancer (HNC) local control. Computed tomographic scan tumor mea- would result in local control of the tumor. surements were used to assess response by standard re- sponse evaluation criteria in solid tumors (RECIST) guide- Design: Radiofrequency ablation was applied to ad- lines. Secondary outcome measures included survival and vanced head and neck malignant tumors in the partici- quality of life. pants of this nonrandomized controlled trial. Results: Eight of 13 participants had stable disease af- Setting: Academic tertiary care medical center. ter intervention. Median survival was 127 days, and an improvement in University of Washington quality-of- Participants: Twenty-one participants with recurrent life scores was noted. Adverse outcomes included http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA Otolaryngology - Head & Neck Surgery American Medical Association

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Publisher
American Medical Association
Copyright
Copyright 2011 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
2168-6181
eISSN
2168-619X
DOI
10.1001/archoto.2011.62
pmid
21576561
Publisher site
See Article on Publisher Site

Abstract

ORIGINAL ARTICLE Radiofrequency Ablation of Advanced Head and Neck Cancer Randall P. Owen, MD, MS; Sajid A. Khan, MD; Abdissa Negassa, PhD; Jonathan J. Beitler, MD, MBA; Jacqueline A. Bello, MD; Allan Brook, MD; Joaquim Farinhas, MD; Madhur K. Garg, MD; Missak Haigentz Jr, MD; Todd S. Miller, MD; Melody S. Hsu, MD; Thanjuvar S. Ravikumar, MD; Keivan Shifteh, MD; Richard V. Smith, MD; Carl E. Silver, MD Objective: To determine if the application of radiofre- Main Outcome Measures: The primary end point was quency ablation to advanced head and neck cancer (HNC) local control. Computed tomographic scan tumor mea- would result in local control of the tumor. surements were used to assess response by standard re- sponse evaluation criteria in solid tumors (RECIST) guide- Design: Radiofrequency ablation was applied to ad- lines. Secondary outcome measures included survival and vanced head and neck malignant tumors in the partici- quality of life. pants of this nonrandomized controlled trial. Results: Eight of 13 participants had stable disease af- Setting: Academic tertiary care medical center. ter intervention. Median survival was 127 days, and an improvement in University of Washington quality-of- Participants: Twenty-one participants with recurrent life scores was noted. Adverse outcomes included

Journal

JAMA Otolaryngology - Head & Neck SurgeryAmerican Medical Association

Published: May 1, 2011

References

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