ORIGINAL ARTICLE Radiofrequency Ablation of Advanced Head and Neck Cancer Randall P. Owen, MD, MS; Sajid A. Khan, MD; Abdissa Negassa, PhD; Jonathan J. Beitler, MD, MBA; Jacqueline A. Bello, MD; Allan Brook, MD; Joaquim Farinhas, MD; Madhur K. Garg, MD; Missak Haigentz Jr, MD; Todd S. Miller, MD; Melody S. Hsu, MD; Thanjuvar S. Ravikumar, MD; Keivan Shifteh, MD; Richard V. Smith, MD; Carl E. Silver, MD Objective: To determine if the application of radiofre- Main Outcome Measures: The primary end point was quency ablation to advanced head and neck cancer (HNC) local control. Computed tomographic scan tumor mea- would result in local control of the tumor. surements were used to assess response by standard re- sponse evaluation criteria in solid tumors (RECIST) guide- Design: Radiofrequency ablation was applied to ad- lines. Secondary outcome measures included survival and vanced head and neck malignant tumors in the partici- quality of life. pants of this nonrandomized controlled trial. Results: Eight of 13 participants had stable disease af- Setting: Academic tertiary care medical center. ter intervention. Median survival was 127 days, and an improvement in University of Washington quality-of- Participants: Twenty-one participants with recurrent life scores was noted. Adverse outcomes included
JAMA Otolaryngology - Head & Neck Surgery – American Medical Association
Published: May 1, 2011
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