CLINICAL SCIENCES Radiation-Related Cancer Risk Associated With Surveillance Imaging for Metastasis From Choroidal Melanoma Joanne C. Wen, MD; Victor Sai, MD; Bradley R. Straatsma, MD, JD; Tara A. McCannel, MD, PhD Objective: To estimate the lifetime attributable risk of mated lifetime attributable risk of cancer of 0.9% for male cancer associated with whole-body positron emission to- patients and 1.3% for female patients, whereas an an- mography (PET)/computed tomography (CT) and with nual PET/CT each year for 10 years carries an estimated CT of the chest, abdomen, and pelvis if performed at vari- lifetime attributable risk of cancer of 1.6% for male pa- ous frequencies and for different durations for surveil- tients and 1.9% for female patients. Lifetime risk was found lance of patients with primary choroidal or ciliary body to be higher in younger, female patients. The lifetime at- melanoma for distant metastasis. tributable risk of cancer was estimated to be as high as 7.9% for a 20-year-old female patient receiving a PET/CT Methods: Effective radiation doses for whole-body CT scan every 6 months for 10 years. and for CT of the chest, abdomen, and pelvis were cal- culated using Monte Carlo simulation studies. The ef- Conclusions: Aggressive surveillance
JAMA Ophthalmology – American Medical Association
Published: Jan 1, 2013
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