Key PointsQuestionWhat is the racial distribution among samples sequenced within The Cancer Genome Atlas and the deficit of samples needed to detect moderately common mutational frequencies in racial minorities? FindingsA review of individual patient data from 5729 samples showed that only 12% were black, 3% were Asian, and 3% were Hispanic. For no racial minorities could we detect a mutational frequency of 5% in any cancer type analyzed. MeaningThere are insufficient samples from racial minorities to detect moderately common genomic alterations in this population, which may be inadvertently widening the already pervasive gap in healthcare disparities.
JAMA Oncology – American Medical Association
Published: Aug 1, 2016