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Racial/Ethnic Disparities in Genomic Sequencing

Racial/Ethnic Disparities in Genomic Sequencing Key PointsQuestionWhat is the racial distribution among samples sequenced within The Cancer Genome Atlas and the deficit of samples needed to detect moderately common mutational frequencies in racial minorities? FindingsA review of individual patient data from 5729 samples showed that only 12% were black, 3% were Asian, and 3% were Hispanic. For no racial minorities could we detect a mutational frequency of 5% in any cancer type analyzed. MeaningThere are insufficient samples from racial minorities to detect moderately common genomic alterations in this population, which may be inadvertently widening the already pervasive gap in healthcare disparities. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA Oncology American Medical Association

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Publisher
American Medical Association
Copyright
Copyright 2016 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
2374-2437
eISSN
2374-2445
DOI
10.1001/jamaoncol.2016.1854
pmid
27366979
Publisher site
See Article on Publisher Site

Abstract

Key PointsQuestionWhat is the racial distribution among samples sequenced within The Cancer Genome Atlas and the deficit of samples needed to detect moderately common mutational frequencies in racial minorities? FindingsA review of individual patient data from 5729 samples showed that only 12% were black, 3% were Asian, and 3% were Hispanic. For no racial minorities could we detect a mutational frequency of 5% in any cancer type analyzed. MeaningThere are insufficient samples from racial minorities to detect moderately common genomic alterations in this population, which may be inadvertently widening the already pervasive gap in healthcare disparities.

Journal

JAMA OncologyAmerican Medical Association

Published: Aug 1, 2016

References