ORIGINAL CONTRIBUTION Quantitative Brain Measurements in Community-Dwelling Elderly Persons With Mild Parkinsonian Signs Elan D. Louis, MD, MSc; Adam M. Brickman, PhD; Charles DeCarli, MD; Scott A. Small, MD; Karen Marder, MD, MPH; Nicole Schupf, PhD; Truman R. Brown, PhD Background: Mild parkinsonian signs (MPS) are a Results: Mild parkinsonian signs were present in 111 of marker of incident dementia. They have been linked with 666 participants (16.7%). Mean (SD) relative WMH vol- cerebrovascular disease, which can be evaluated using ume was larger in participants with MPS vs those without magnetic resonance imaging (MRI). Also, if MPS are a MPS (1.70 [1.28] vs 1.17 [1.18]; P .001). In a multivar- marker for developing Alzheimer-type changes, hippo- iate logistic regression analysis adjusting for age, sex, race/ campal volume on MRI might be diminished in indi- ethnicity, years of educational achievement, and depres- viduals with MPS. sion, relative WMH volume was associated with MPS (odds ratio, 1.26; 95% confidence interval, 1.08-1.47; P = .004). Objective: To examine white matter hyperintensity In both unadjusted and adjusted analyses, total relative hip- (WMH) volume and total hippocampal volume in el- pocampal volume was similar in participants with MPS vs derly individuals with and without
JAMA Neurology – American Medical Association
Published: Dec 1, 2008
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