Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You and Your Team.

Learn More →

Quantitative Brain Measurements in Community-Dwelling Elderly Persons With Mild Parkinsonian Signs

Quantitative Brain Measurements in Community-Dwelling Elderly Persons With Mild Parkinsonian Signs ORIGINAL CONTRIBUTION Quantitative Brain Measurements in Community-Dwelling Elderly Persons With Mild Parkinsonian Signs Elan D. Louis, MD, MSc; Adam M. Brickman, PhD; Charles DeCarli, MD; Scott A. Small, MD; Karen Marder, MD, MPH; Nicole Schupf, PhD; Truman R. Brown, PhD Background: Mild parkinsonian signs (MPS) are a Results: Mild parkinsonian signs were present in 111 of marker of incident dementia. They have been linked with 666 participants (16.7%). Mean (SD) relative WMH vol- cerebrovascular disease, which can be evaluated using ume was larger in participants with MPS vs those without magnetic resonance imaging (MRI). Also, if MPS are a MPS (1.70 [1.28] vs 1.17 [1.18]; P .001). In a multivar- marker for developing Alzheimer-type changes, hippo- iate logistic regression analysis adjusting for age, sex, race/ campal volume on MRI might be diminished in indi- ethnicity, years of educational achievement, and depres- viduals with MPS. sion, relative WMH volume was associated with MPS (odds ratio, 1.26; 95% confidence interval, 1.08-1.47; P = .004). Objective: To examine white matter hyperintensity In both unadjusted and adjusted analyses, total relative hip- (WMH) volume and total hippocampal volume in el- pocampal volume was similar in participants with MPS vs derly individuals with and without http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA Neurology American Medical Association

Quantitative Brain Measurements in Community-Dwelling Elderly Persons With Mild Parkinsonian Signs

Loading next page...
 
/lp/american-medical-association/quantitative-brain-measurements-in-community-dwelling-elderly-persons-4yrC6JC4cf
Publisher
American Medical Association
Copyright
Copyright 2008 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
2168-6149
eISSN
2168-6157
DOI
10.1001/archneurol.2008.504
pmid
19064753
Publisher site
See Article on Publisher Site

Abstract

ORIGINAL CONTRIBUTION Quantitative Brain Measurements in Community-Dwelling Elderly Persons With Mild Parkinsonian Signs Elan D. Louis, MD, MSc; Adam M. Brickman, PhD; Charles DeCarli, MD; Scott A. Small, MD; Karen Marder, MD, MPH; Nicole Schupf, PhD; Truman R. Brown, PhD Background: Mild parkinsonian signs (MPS) are a Results: Mild parkinsonian signs were present in 111 of marker of incident dementia. They have been linked with 666 participants (16.7%). Mean (SD) relative WMH vol- cerebrovascular disease, which can be evaluated using ume was larger in participants with MPS vs those without magnetic resonance imaging (MRI). Also, if MPS are a MPS (1.70 [1.28] vs 1.17 [1.18]; P .001). In a multivar- marker for developing Alzheimer-type changes, hippo- iate logistic regression analysis adjusting for age, sex, race/ campal volume on MRI might be diminished in indi- ethnicity, years of educational achievement, and depres- viduals with MPS. sion, relative WMH volume was associated with MPS (odds ratio, 1.26; 95% confidence interval, 1.08-1.47; P = .004). Objective: To examine white matter hyperintensity In both unadjusted and adjusted analyses, total relative hip- (WMH) volume and total hippocampal volume in el- pocampal volume was similar in participants with MPS vs derly individuals with and without

Journal

JAMA NeurologyAmerican Medical Association

Published: Dec 1, 2008

References

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Search

Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly

Organize

Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.

Access

Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

DeepDyve

Freelancer

DeepDyve

Pro

Price

FREE

$49/month
$499/year

Save searches from
Google Scholar,
PubMed

Create folders to
organize your research

Export folders, citations

Read DeepDyve articles

Abstract access only

Unlimited access to over
18 million full-text articles

Print

20 pages / month