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QUANTITATIVE ABSORPTION OF PHENOLSULFONPHTHALEIN FROM SUBARACHNOID SPACE

QUANTITATIVE ABSORPTION OF PHENOLSULFONPHTHALEIN FROM SUBARACHNOID SPACE Abstract In the study of normal and abnormal physiology of the nervous system it would be of considerable assistance to the clinician to know the quantitative return of the cerebrospinal fluid into the blood stream per unit of time. It has long been known that certain substances when injected subarachnoidally eventually appear in the urine. In their study of such agents, the quantitative output of which from the subarachnoid space could easily be determined in the urine, Dandy and Blackfan1 adopted neutral phenolsulfonphthalein for clinical use. After experimental trials it was concluded by these investigators that the quantitative results of the absorption of this dye from the human subarachnoid space are similar to those in animals; that is, for approximately three to four hours the absorption is fairly constant and then diminishes progressively as dilution with fresh fluid occurs. The dye appears in the urine in from six to eight References 1. Dandy, W. E., and Blackfan, K. D.: An Experimental and Clinical Study of Internal Hydrocephalus , J. A. M. A. 61:2216-2217 ( (Dec. 20) ) 1913.Crossref 2. Mehrtens, H. G., and West, H. F.: The Absorption of Phenolsulphonephthalein from the Subarachnoid Space in Diseases of the Central Nervous System , Arch. Int. Med. 20:575-585 ( (Oct.) ) 1917.Crossref 3. Weston, P. G.: Phenolsulphonephthalein Absorption from the Subarachnoid Space in Paresis and Dementia Praecox , Arch. Neurol. & Psychiat. 5:58-63 ( (Jan.) ) 1921. 4. Kendall, E. C.: The Fate of Phenolsulphonephthalein When Injected into the Animal Organism , J. A. M. A. 68:343-345 ( (Feb. 3) ) 1915. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Neurology & Psychiatry American Medical Association

QUANTITATIVE ABSORPTION OF PHENOLSULFONPHTHALEIN FROM SUBARACHNOID SPACE

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Publisher
American Medical Association
Copyright
Copyright © 1939 American Medical Association. All Rights Reserved.
ISSN
0096-6754
DOI
10.1001/archneurpsyc.1939.02270150058004
Publisher site
See Article on Publisher Site

Abstract

Abstract In the study of normal and abnormal physiology of the nervous system it would be of considerable assistance to the clinician to know the quantitative return of the cerebrospinal fluid into the blood stream per unit of time. It has long been known that certain substances when injected subarachnoidally eventually appear in the urine. In their study of such agents, the quantitative output of which from the subarachnoid space could easily be determined in the urine, Dandy and Blackfan1 adopted neutral phenolsulfonphthalein for clinical use. After experimental trials it was concluded by these investigators that the quantitative results of the absorption of this dye from the human subarachnoid space are similar to those in animals; that is, for approximately three to four hours the absorption is fairly constant and then diminishes progressively as dilution with fresh fluid occurs. The dye appears in the urine in from six to eight References 1. Dandy, W. E., and Blackfan, K. D.: An Experimental and Clinical Study of Internal Hydrocephalus , J. A. M. A. 61:2216-2217 ( (Dec. 20) ) 1913.Crossref 2. Mehrtens, H. G., and West, H. F.: The Absorption of Phenolsulphonephthalein from the Subarachnoid Space in Diseases of the Central Nervous System , Arch. Int. Med. 20:575-585 ( (Oct.) ) 1917.Crossref 3. Weston, P. G.: Phenolsulphonephthalein Absorption from the Subarachnoid Space in Paresis and Dementia Praecox , Arch. Neurol. & Psychiat. 5:58-63 ( (Jan.) ) 1921. 4. Kendall, E. C.: The Fate of Phenolsulphonephthalein When Injected into the Animal Organism , J. A. M. A. 68:343-345 ( (Feb. 3) ) 1915.

Journal

Archives of Neurology & PsychiatryAmerican Medical Association

Published: Mar 1, 1939

References