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Pyridoxine Hydrochloride (Vitamin B6) Need in Infants and Children: A Study in Patients with Anemia, Convulsions, and Acute Infections

Pyridoxine Hydrochloride (Vitamin B6) Need in Infants and Children: A Study in Patients with... Abstract The clinical manifestations of pyridoxine deficiency in infants have been described in recent reports. Snyderman and co-workers1 noted the occurrence of microcytic, hypochromic anemia in one and convulsions in the second of two infants maintained on a diet deficient in pyridoxine hyrdochloride for a prolonged period of time. The clinical manifestations were improved by adding pyridoxine hydrochloride to the basal diet. Convulsions occurred in a group of infants fed milk mixtures deficient in pyridoxine hydrochloride according to reports by Coursin2 and Moloney and Parmelee.3 This symptom did not recur when the diet contained adequate amounts of pyridoxine hydrochloride. It is noteworthy that the infants reported in detail were all under 3 months of age, save for the two children reported by Snyderman, who were 8 months and 2 years of age, respectively. Stimulated by these reports we have sought evidence of pyridoxine need in a small group References 1. Synderman, S. E.; Holt, L. E., Jr.; Carretero, R., and Jacobs, K. G.: Pyridoxine Deficiency in the Human Infant , J. Clin. Nutrition. 1:200, 1953. 2. Coursin, D. B.: Convulsive Seizures in Infants with Pyridoxine-Deficient Diet , J. A. M. A. 154:406, 1954.Crossref 3. Moloney, C. J., and Parmelee, A. H.: Convulsions in Young Infants as a Result of Pyridoxine (Vitamin B6) Deficiency , J. A. M. A. 154:405, 1954.Crossref 4. Wachstein, M., and Gudaitis, A.: Disturbance of Vitamin B6 Metabolism in Pregnancy , J. Lab. & Clin. Med. 40:550, 1952. 5. Adam, D. J. D.; Bessey, O. A.; Bussey, D. R., and Hansen, A. E.: Vitamin B6 Requirement in Relation to Convulsive Seizures in Infants , A.M.A. Am. J. Dis. Child. 88:623, 1954. 6. Perlzweig, W. A.; Rosen, F.; Levitas, N., and Robinson, J.: The Excretion of Nicotinic Acid Derivatives After Ingestion of Tryptophane by Man , J. Biol. Chem. 167:511, 1947. 7. Huff, J. W., and Perlzweig, W. A.: The Fluorescent Condensation Product of N1-Methylnicotinamide and Acetone: II. A Sensitive Method for the Determination of N1-Methylnicotinamide in Urine , J. Biol. Chem. 167:157, 1947. 8. Sarett, H. P.: A Study of the Measurement of 4-Pyridoxic Acid in Urine , J. Biol. Chem. 189:769, 1951. 9. Wachstein, M., and Gudaitis, A.; Detection of Vitamin B6 Deficiency: Utilization of Improved Method for Rapid Determination of Xanthurenic Acid in Urine , Am. J. Clin. Path. 22:652, 1952. 10. Huff, J. W., and Perlzweig, W. A.: A Product of Oxidative Metabolism of Pyridoxine-2 Methyl-3 Hydroxy-4 Carboxy-5-Hydroxy-Methylpyridine (4-Pyridoxic Acid) , J. Biol. Chem. 155:345, 1944. 11. Wintrobe, M. M., and others: Pyridoxine Deficiency in Swine with Particular Reference to Anemia, Epileptiform Convulsions and Fatty Liver , Bull. Johns Hopkins Hosp. 72:1, 1943. 12. Rabinowitz, J. C., and Snell, E. E.: Vitamin B6 Group: Urinary Excretion of Pyridoxal, Pyridoxamine, Pyridoxine, and 4-Pyridoxic Acid in Human Subjects , Proc. Soc. Exper. Biol. & Med. 70:235, 1949. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png A.M.A. Journal of Diseases of Children American Medical Association

Pyridoxine Hydrochloride (Vitamin B6) Need in Infants and Children: A Study in Patients with Anemia, Convulsions, and Acute Infections

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Publisher
American Medical Association
Copyright
Copyright © 1956 American Medical Association. All Rights Reserved.
ISSN
0096-6916
DOI
10.1001/archpedi.1956.02060030376007
Publisher site
See Article on Publisher Site

Abstract

Abstract The clinical manifestations of pyridoxine deficiency in infants have been described in recent reports. Snyderman and co-workers1 noted the occurrence of microcytic, hypochromic anemia in one and convulsions in the second of two infants maintained on a diet deficient in pyridoxine hyrdochloride for a prolonged period of time. The clinical manifestations were improved by adding pyridoxine hydrochloride to the basal diet. Convulsions occurred in a group of infants fed milk mixtures deficient in pyridoxine hydrochloride according to reports by Coursin2 and Moloney and Parmelee.3 This symptom did not recur when the diet contained adequate amounts of pyridoxine hydrochloride. It is noteworthy that the infants reported in detail were all under 3 months of age, save for the two children reported by Snyderman, who were 8 months and 2 years of age, respectively. Stimulated by these reports we have sought evidence of pyridoxine need in a small group References 1. Synderman, S. E.; Holt, L. E., Jr.; Carretero, R., and Jacobs, K. G.: Pyridoxine Deficiency in the Human Infant , J. Clin. Nutrition. 1:200, 1953. 2. Coursin, D. B.: Convulsive Seizures in Infants with Pyridoxine-Deficient Diet , J. A. M. A. 154:406, 1954.Crossref 3. Moloney, C. J., and Parmelee, A. H.: Convulsions in Young Infants as a Result of Pyridoxine (Vitamin B6) Deficiency , J. A. M. A. 154:405, 1954.Crossref 4. Wachstein, M., and Gudaitis, A.: Disturbance of Vitamin B6 Metabolism in Pregnancy , J. Lab. & Clin. Med. 40:550, 1952. 5. Adam, D. J. D.; Bessey, O. A.; Bussey, D. R., and Hansen, A. E.: Vitamin B6 Requirement in Relation to Convulsive Seizures in Infants , A.M.A. Am. J. Dis. Child. 88:623, 1954. 6. Perlzweig, W. A.; Rosen, F.; Levitas, N., and Robinson, J.: The Excretion of Nicotinic Acid Derivatives After Ingestion of Tryptophane by Man , J. Biol. Chem. 167:511, 1947. 7. Huff, J. W., and Perlzweig, W. A.: The Fluorescent Condensation Product of N1-Methylnicotinamide and Acetone: II. A Sensitive Method for the Determination of N1-Methylnicotinamide in Urine , J. Biol. Chem. 167:157, 1947. 8. Sarett, H. P.: A Study of the Measurement of 4-Pyridoxic Acid in Urine , J. Biol. Chem. 189:769, 1951. 9. Wachstein, M., and Gudaitis, A.; Detection of Vitamin B6 Deficiency: Utilization of Improved Method for Rapid Determination of Xanthurenic Acid in Urine , Am. J. Clin. Path. 22:652, 1952. 10. Huff, J. W., and Perlzweig, W. A.: A Product of Oxidative Metabolism of Pyridoxine-2 Methyl-3 Hydroxy-4 Carboxy-5-Hydroxy-Methylpyridine (4-Pyridoxic Acid) , J. Biol. Chem. 155:345, 1944. 11. Wintrobe, M. M., and others: Pyridoxine Deficiency in Swine with Particular Reference to Anemia, Epileptiform Convulsions and Fatty Liver , Bull. Johns Hopkins Hosp. 72:1, 1943. 12. Rabinowitz, J. C., and Snell, E. E.: Vitamin B6 Group: Urinary Excretion of Pyridoxal, Pyridoxamine, Pyridoxine, and 4-Pyridoxic Acid in Human Subjects , Proc. Soc. Exper. Biol. & Med. 70:235, 1949.

Journal

A.M.A. Journal of Diseases of ChildrenAmerican Medical Association

Published: Oct 1, 1956

References

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