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Pyogenic Granuloma Presenting as a Congenital Epulis

Pyogenic Granuloma Presenting as a Congenital Epulis ObjectiveTo describe a clinical approach to the differential diagnosis of oral lesions in neonates.DesignCase report.SettingAcademic ambulatory care center.ParticipantsMale infant.ResultsA gingival mass in a male infant appeared clinically consistent with a congenital epulis. Following excision and histologic examination, the diagnosis was determined to be a pyogenic granuloma. Careful attention to alternative diagnoses led to the correct etiology.ConclusionsPrimary care pediatricians encounter neonatal oral lesions infrequently. The most common oral lesions in the newborn period are Epstein pearls and Bohn nodules. This case illustrates the importance of formulating a more extensive differential diagnosis on discovery of a neonatal oral mass.THE ORAL examination is an essential part of the routine physical examination of the newborn. When a mass is found in the oral cavity, it is important to formulate a differential diagnosis since this will help guide further evaluation of the condition and management of the patient. Most of the information regarding oral lesions in the newborn is found in the dental, surgical, and pathology literature, but very little exists in the pediatric literature. This case report describes a male infant with a gingival mass presenting clinically as a congenital epulis of the newborn; however, histologically it proved to be a pyogenic granuloma.PATIENT REPORTA 2.7-kg 364-g male infant was born after uncomplicated normal spontaneous vaginal delivery to a 34-year-old gravida 2 para 2 Vietnamese woman. On physical examination performed shortly after delivery, he was found to have a 1- to 2-mm whitish cystic lesion over the right anterior maxillary alveolar ridge. The pregnancy had been uncomplicated. The infant's Apgar scores were 9 and 9 at 1 and 5 minutes, respectively. At his routine newborn visit on the third day of life, the lesion had evolved into a 2 × 2-cm yellow mass. The mass changed over the course of 1 week, leaving a residual, flat, yellow lesion. Over the next week, the lesion grew, becoming fluctuant, fleshy, and pedunculated (Figure 1). The diagnosis at this time was a mucocele, and he was referred to a pediatric dentist for further evaluation. At this visit he was thought to have a Bohn nodule (a firm, yellow white mucous gland cyst) vs an Epstein pearl (a keratin-filled cystic lesion lined with stratified squamous epithelium).Figure 1.A lesion found in the patient at routine newborn visit grew and 1 week later became fluctuant, fleshy, and pedunculated as seen here and was diagnosed as a mucocele.At age 5 weeks, the infant was evaluated by a maxillofacial surgeon. A diagnosis of congenital epulis of the newborn was made and a period of observation was recommended. The infant continued to breastfeed well with normal growth parameters, and he had no respiratory difficulty. At 7½ months of age, because of interference with teething, the mass was excised under general anesthesia. The specimen consisted of a 1 × 0.8 × 0.5-cm, irregularly shaped, lobulated mass with a smooth and glistening surface. Microscopic examination revealed polypoid nodules covered by acanthotic, nonkeratinized stratified squamous epithelium and edematous fibrous connective tissue containing prominent blood vessels. Epithelial collarette formation was present (Figure 2). Although this lesion clinically appeared to be an epulis, it was histologically most consistent with a pyogenic granuloma.Figure 2.Microscopic examination of excised mass when patient was age 7½ months. Epithelial collarette formation was present. The lesion was histologically most consistent with a pyogenic granuloma (hematoxylin-eosin, original magnification × 100).COMMENTPyogenic granuloma, or the currently preferred histologic term lobular capillary hemangioma, occurs during infancy, typically as a single polypoid nodule that bleeds easily on palpation. The face, lip, and oral cavity, particularly the gingiva, and umbilicus are common sites.It is usually painless, develops rapidly, and may range in size from a few millimeters to a few centimeters. The current thinking is that this lesion represents a benign neoplasm, a form of capillary hemangioma, rather than a reactive infectious or traumatic process.Pyogenic granuloma has a diagnostic, lobular arrangement of capillaries at its base. The lobules are composed of discrete clusters of endothelial cells, and the lumina vary from indistinct to prominent. The surface of the lesion may undergo secondary, nonspecific changes that include stromal edema, capillary dilation, inflammation, and a granulation tissue reaction.The presence of an epithelial collarette, which was present in our patient (Figure 2), distinguishes the pyogenic granuloma from a capillary hemangioma.Management consists of complete surgical excision.If not completely excised, the lesion eventually scleroses.Hemangiomas are the most common soft tissue masses found in the newborn, occurring in approximately 2% of neonates and 10% of infants. In a retrospective review by Sato et al,hemangiomas were found to be the most common pediatric benign tumors of the oral mucosa. They may appear singly or as multiple lesions, as in infantile hemangiomatosis. Some may regress spontaneously; however, others may require removal by cryosurgery, sclerosing agents, or laser.Other oral cavity conditions to consider in the differential diagnosis are Epsteins pearls, Bohn nodules, viral enanthems, granular cell tumors, natal teeth, hemangiomas, reparative giant cell granulomas, teratomas, gingival cysts, ranulas, and melanotic neuroectodermal tumor of infancy (Table 1). Trying to make a definitive diagnosis can present a challenge to the primary care pediatrician as it did in this case. Although the mass appeared clinically to be a congenital epulis (granular cell tumor), the absence of the characteristic large cells with granular cytoplasmsessentially ruled out this entity. The histologic findings are most consistent with an old pyogenic granuloma.Masses of the Oral CavityMassLocationDescriptionManagementEpstein pearlGingiva or palateWhitish keratin-filled cystic lesion lined with stratified epitheliumSpontaneous resolutionBohn noduleRoof of mouth near midlineSmall white yellow nodules <3 mm in diameter arising as retention cysts in mucous glandsSpontaneous resolutionViral enanthemSoft palate, gingiva, oropharynxVesicular lesionsSpontaneous resolutionCongenital epulis (granular cell tumor)Maxillary and/or mandibular alveolar ridgeFirm, pedunculated mass with a smooth or lobulated surface, several millimeters to 9 cm in diameterConservative: removal if interferes with feeding, teething, or respirationReparative giant cell granulomaGingiva, adjacent boneFirm, well-circumscribed red brown nodule with a pedunculated base (0.5-1.5 cm); multinucleated giant cells, fibroblastsSurgical excisionNatal teethMandibular incisor areaOften in pairsConservative: extract if poor crown formation or mobilePyogenic granuloma*GingivaRed, polypoid nodule with epithelial collarette, proliferating capillaries and fibroblasts; prone to bleed with manipulationSurgical excisionHemangiomaGingiva; may have associated cutaneous hemangioma(s)Red nodule; lobules of proliferating capillaries; no collaretteSpontaneous resolution; excise if complicationsTeratomaPalateTissues derived from all 3 germ layers; tumor may or may not contain body partsSurgical excisionGingival cystMaxillary or mandibular alveolar ridgeGrayish white cystic enlargement of the enamel organ presenting as a noduleSpontaneous resolutionRanula (mucocele)Minor salivary glandsSublingual retention cyst lined by mucous-secreting cellsSurgical excision if spontaneous resolution does not occurMelanotic neuroectodermal tumor of infancyMaxillary alveolar ridgeSmooth surfaced, bluish black nodule; small neuroblastic cells and larger pigmented melanocytic cellsComplete surgical excision*The currently preferred histologic term is lobular capillary hemangioma.Most oral masses encountered in the neonatal period, including teratomas, are benign except for the melanotic neuroectodermal tumor, which occasionally represents a malignant process.Although hemangiomas, including pyogenic granuloma, are the principal benign conditions of the oral mucosa in children, the most common oral lesions in the newborn period are Epstein pearls and Bohn nodules. This case illustrates the importance of a complete oral examination at the initial newborn visit as well as at subsequent office visits.BUMuellerJBMullikenThe infant with a vascular tumor.Semin Perinatol.1999;23:332-340.SEMillsPHCooperREFechnerLobular capillary hemangioma: the underlying lesion of pyogenic granuloma: a study of 73 cases from the oral and nasal mucous membranes.Am J Surg Pathol.1980;4:470-479.HIsaacs JrTumors of the Fetus and Newborn.Vol 35. Philadelphia, Pa: WB Saunders Co; 1997.DCDilleyMASiegelSBudnickDiagnosing and treating common oral pathologies.Pediatr Clin North Am.1991;38:1227-1264.MSatoNTanakaTSatoTAmagasaOral and maxillofacial tumours in children: a review.Br J Oral Maxillofac Surg.1997;35:92-95.MKershisnikJGBatsakisBMacKayPathology consultation: granular cell tumors.Ann Otol Rhinol Laryngol.1994;103:416-419.Accepted for publication November 16, 1999.Corresponding author: Lindia J. Willies-Jacobo, MD, Division of Primary Care Pediatrics, Department of Pediatrics, University of California San Diego Medical Center, 200 W Arbor Dr, No. 8464, San Diego, CA 92103-8464. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA Pediatrics American Medical Association

Pyogenic Granuloma Presenting as a Congenital Epulis

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American Medical Association
Copyright
Copyright 2000 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
2168-6203
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2168-6211
DOI
10.1001/archpedi.154.6.603
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Abstract

ObjectiveTo describe a clinical approach to the differential diagnosis of oral lesions in neonates.DesignCase report.SettingAcademic ambulatory care center.ParticipantsMale infant.ResultsA gingival mass in a male infant appeared clinically consistent with a congenital epulis. Following excision and histologic examination, the diagnosis was determined to be a pyogenic granuloma. Careful attention to alternative diagnoses led to the correct etiology.ConclusionsPrimary care pediatricians encounter neonatal oral lesions infrequently. The most common oral lesions in the newborn period are Epstein pearls and Bohn nodules. This case illustrates the importance of formulating a more extensive differential diagnosis on discovery of a neonatal oral mass.THE ORAL examination is an essential part of the routine physical examination of the newborn. When a mass is found in the oral cavity, it is important to formulate a differential diagnosis since this will help guide further evaluation of the condition and management of the patient. Most of the information regarding oral lesions in the newborn is found in the dental, surgical, and pathology literature, but very little exists in the pediatric literature. This case report describes a male infant with a gingival mass presenting clinically as a congenital epulis of the newborn; however, histologically it proved to be a pyogenic granuloma.PATIENT REPORTA 2.7-kg 364-g male infant was born after uncomplicated normal spontaneous vaginal delivery to a 34-year-old gravida 2 para 2 Vietnamese woman. On physical examination performed shortly after delivery, he was found to have a 1- to 2-mm whitish cystic lesion over the right anterior maxillary alveolar ridge. The pregnancy had been uncomplicated. The infant's Apgar scores were 9 and 9 at 1 and 5 minutes, respectively. At his routine newborn visit on the third day of life, the lesion had evolved into a 2 × 2-cm yellow mass. The mass changed over the course of 1 week, leaving a residual, flat, yellow lesion. Over the next week, the lesion grew, becoming fluctuant, fleshy, and pedunculated (Figure 1). The diagnosis at this time was a mucocele, and he was referred to a pediatric dentist for further evaluation. At this visit he was thought to have a Bohn nodule (a firm, yellow white mucous gland cyst) vs an Epstein pearl (a keratin-filled cystic lesion lined with stratified squamous epithelium).Figure 1.A lesion found in the patient at routine newborn visit grew and 1 week later became fluctuant, fleshy, and pedunculated as seen here and was diagnosed as a mucocele.At age 5 weeks, the infant was evaluated by a maxillofacial surgeon. A diagnosis of congenital epulis of the newborn was made and a period of observation was recommended. The infant continued to breastfeed well with normal growth parameters, and he had no respiratory difficulty. At 7½ months of age, because of interference with teething, the mass was excised under general anesthesia. The specimen consisted of a 1 × 0.8 × 0.5-cm, irregularly shaped, lobulated mass with a smooth and glistening surface. Microscopic examination revealed polypoid nodules covered by acanthotic, nonkeratinized stratified squamous epithelium and edematous fibrous connective tissue containing prominent blood vessels. Epithelial collarette formation was present (Figure 2). Although this lesion clinically appeared to be an epulis, it was histologically most consistent with a pyogenic granuloma.Figure 2.Microscopic examination of excised mass when patient was age 7½ months. Epithelial collarette formation was present. The lesion was histologically most consistent with a pyogenic granuloma (hematoxylin-eosin, original magnification × 100).COMMENTPyogenic granuloma, or the currently preferred histologic term lobular capillary hemangioma, occurs during infancy, typically as a single polypoid nodule that bleeds easily on palpation. The face, lip, and oral cavity, particularly the gingiva, and umbilicus are common sites.It is usually painless, develops rapidly, and may range in size from a few millimeters to a few centimeters. The current thinking is that this lesion represents a benign neoplasm, a form of capillary hemangioma, rather than a reactive infectious or traumatic process.Pyogenic granuloma has a diagnostic, lobular arrangement of capillaries at its base. The lobules are composed of discrete clusters of endothelial cells, and the lumina vary from indistinct to prominent. The surface of the lesion may undergo secondary, nonspecific changes that include stromal edema, capillary dilation, inflammation, and a granulation tissue reaction.The presence of an epithelial collarette, which was present in our patient (Figure 2), distinguishes the pyogenic granuloma from a capillary hemangioma.Management consists of complete surgical excision.If not completely excised, the lesion eventually scleroses.Hemangiomas are the most common soft tissue masses found in the newborn, occurring in approximately 2% of neonates and 10% of infants. In a retrospective review by Sato et al,hemangiomas were found to be the most common pediatric benign tumors of the oral mucosa. They may appear singly or as multiple lesions, as in infantile hemangiomatosis. Some may regress spontaneously; however, others may require removal by cryosurgery, sclerosing agents, or laser.Other oral cavity conditions to consider in the differential diagnosis are Epsteins pearls, Bohn nodules, viral enanthems, granular cell tumors, natal teeth, hemangiomas, reparative giant cell granulomas, teratomas, gingival cysts, ranulas, and melanotic neuroectodermal tumor of infancy (Table 1). Trying to make a definitive diagnosis can present a challenge to the primary care pediatrician as it did in this case. Although the mass appeared clinically to be a congenital epulis (granular cell tumor), the absence of the characteristic large cells with granular cytoplasmsessentially ruled out this entity. The histologic findings are most consistent with an old pyogenic granuloma.Masses of the Oral CavityMassLocationDescriptionManagementEpstein pearlGingiva or palateWhitish keratin-filled cystic lesion lined with stratified epitheliumSpontaneous resolutionBohn noduleRoof of mouth near midlineSmall white yellow nodules <3 mm in diameter arising as retention cysts in mucous glandsSpontaneous resolutionViral enanthemSoft palate, gingiva, oropharynxVesicular lesionsSpontaneous resolutionCongenital epulis (granular cell tumor)Maxillary and/or mandibular alveolar ridgeFirm, pedunculated mass with a smooth or lobulated surface, several millimeters to 9 cm in diameterConservative: removal if interferes with feeding, teething, or respirationReparative giant cell granulomaGingiva, adjacent boneFirm, well-circumscribed red brown nodule with a pedunculated base (0.5-1.5 cm); multinucleated giant cells, fibroblastsSurgical excisionNatal teethMandibular incisor areaOften in pairsConservative: extract if poor crown formation or mobilePyogenic granuloma*GingivaRed, polypoid nodule with epithelial collarette, proliferating capillaries and fibroblasts; prone to bleed with manipulationSurgical excisionHemangiomaGingiva; may have associated cutaneous hemangioma(s)Red nodule; lobules of proliferating capillaries; no collaretteSpontaneous resolution; excise if complicationsTeratomaPalateTissues derived from all 3 germ layers; tumor may or may not contain body partsSurgical excisionGingival cystMaxillary or mandibular alveolar ridgeGrayish white cystic enlargement of the enamel organ presenting as a noduleSpontaneous resolutionRanula (mucocele)Minor salivary glandsSublingual retention cyst lined by mucous-secreting cellsSurgical excision if spontaneous resolution does not occurMelanotic neuroectodermal tumor of infancyMaxillary alveolar ridgeSmooth surfaced, bluish black nodule; small neuroblastic cells and larger pigmented melanocytic cellsComplete surgical excision*The currently preferred histologic term is lobular capillary hemangioma.Most oral masses encountered in the neonatal period, including teratomas, are benign except for the melanotic neuroectodermal tumor, which occasionally represents a malignant process.Although hemangiomas, including pyogenic granuloma, are the principal benign conditions of the oral mucosa in children, the most common oral lesions in the newborn period are Epstein pearls and Bohn nodules. This case illustrates the importance of a complete oral examination at the initial newborn visit as well as at subsequent office visits.BUMuellerJBMullikenThe infant with a vascular tumor.Semin Perinatol.1999;23:332-340.SEMillsPHCooperREFechnerLobular capillary hemangioma: the underlying lesion of pyogenic granuloma: a study of 73 cases from the oral and nasal mucous membranes.Am J Surg Pathol.1980;4:470-479.HIsaacs JrTumors of the Fetus and Newborn.Vol 35. Philadelphia, Pa: WB Saunders Co; 1997.DCDilleyMASiegelSBudnickDiagnosing and treating common oral pathologies.Pediatr Clin North Am.1991;38:1227-1264.MSatoNTanakaTSatoTAmagasaOral and maxillofacial tumours in children: a review.Br J Oral Maxillofac Surg.1997;35:92-95.MKershisnikJGBatsakisBMacKayPathology consultation: granular cell tumors.Ann Otol Rhinol Laryngol.1994;103:416-419.Accepted for publication November 16, 1999.Corresponding author: Lindia J. Willies-Jacobo, MD, Division of Primary Care Pediatrics, Department of Pediatrics, University of California San Diego Medical Center, 200 W Arbor Dr, No. 8464, San Diego, CA 92103-8464.

Journal

JAMA PediatricsAmerican Medical Association

Published: Jun 1, 2000

References