Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

Purpura of Idiopathic Hyperglobulinemia: Waldenström's Purpura Hyperglobulinemica

Purpura of Idiopathic Hyperglobulinemia: Waldenström's Purpura Hyperglobulinemica Abstract Hemorrhagic disturbances may be classified in four groups on the basis of their presumptive pathogenetic mechanism as follows: (1) those due to a primary defect of the vascular wall; (2) those due to a qualitative or quantitative platelet deficiency; (3) those due to abnormalities in the blood coagulation factors, and (4) those due to qualitative or quantitative disturbances of the blood proteins (dysproteinemias).19 Related to the last group, Waldenström16 described a new syndrome, namely "purpura hyperglobulinemica," characterized by relapsing purpura of the lower extremities, persistent increase of the serum-globulin fraction, mild normochromic anemia, leukopenia, elevated erythrosedimentation rate (E. S. R.) and increased total serum proteins between 8.7 and 9.8 gm. per 100 cc. Waldenström performed electrophoretic studies on the three original patients and four additional cases.17,18 These studies disclosed the following: The hyperglobulinemia was due to an increase of References 1. Dr. Rein died May 15, 1957. 2. Apitz, K.: Die Paraproteinosen (Über die Störung des Eiweisstoffwechsels bei Plasmocytom) , Arch. path. Anat. 306:631, 1940.Crossref 3. Curtz, F. R.: Purpura Hyperglobulinaemica , Ugesk. læger , 108:340, 1946. 4. Dorken, H.: Primäre und sekundäre Purpura hyperglobulinaemica , Acta haemat. 10:340, 1953.Crossref 5. Fallet, G. H., and Haenni, A.: A propos d'un nouveau cas de purpura hyperglobulinémique de Waldenstroem , Praxis 43:71, 1954. 6. Horster, J. A.: Purpura hyperglobulinaemica (morphologische Besonderheiten und pathogenetische Untersuchungen) , Acta haemat. 4:201, 1950.Crossref 7. Humerfelt, S.: Purpura with Hyperglobulinemia , Nord. med. 34:1101, 1947. 8. Kay, H. E. M., and Robertson, K. M.: Benign Hyperglobulinaemic Purpura , J. Path. & Bact. 70:543, 1955. 9. Lindeboom, G. A.: Purpura Hyperglobulinemica , Dermatologica 96:337, 1948. 10. Linke, A.: Primäre und sekundäre Dysproteinämie mit Purpura- und Raynaud-Syndrom , Arch. Dermat. u. Syph. 191:123, 1950. 11. Oberste-Lehn, H.: Ein Fall von Purpura hyperglobulinaemica unter dem Bilde der Schambergschen Erkrankung , Zentralbl. Haut- u. Geschlechtskr. 7:404, 1949-1950. 12. Schmengler, F. E., and Esser, H.: Zur Pathogenese der Purpura hyperglobulinaemica , Klin. Wchnschr. 30:30, 1952. 13. Seiden, G. E., and Wurzel, H. A.: Idiopathic Benign Hyperglobulinemic Purpura , New England J. Med. 255:170, 1956. 14. Stefanini, M., and Dameshek, W.: The Hemorrhagic Disorders , New York, Grune & Stratton, Inc., 1955, p. 235. 15. Taylor, F. E., and Battle, J. D.: Benign Hyperglobulinemic Purpura: Case Report , Ann. Int. Med. 40:350, 1954. 16. Vannuchi, V., and Doni, A.: A proposito di un caso di porpora iperglobulinemica , Riv. crit. clin. med. 54:4, 1954. 17. Waldrenström, J.: Clinical Methods for Determination of Hyperproteinemia and Their Practical Value for Diagnosis; Contribution to Study of Essential High Sedimentation Reaction , Nord. med. 20:2288, 1943. 18. Waldenström, J.: Zwei interessante Syndrome mit Hyperglobulinämie (Purpura Hyperglobulinaemica und Makroglobulinämie) , Schweiz. Med. Wchnschr. 78:927, 1948. 19. Waldenström, J.: Three New Cases of Purpura Hyperglobulinemica: A Study in Long Lasting Increase in Serum Globulin , Acta med. scandinav. ( (Supp. 226) ) 142:931, 1952. 20. Wuhrmann, F., and Wunderly, C.: Las proteinas sanguineas en el hombre , Editorial cientifico médica, Madrid, 1949. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png A.M.A. Archives of Dermatology American Medical Association

Purpura of Idiopathic Hyperglobulinemia: Waldenström's Purpura Hyperglobulinemica

Loading next page...
 
/lp/american-medical-association/purpura-of-idiopathic-hyperglobulinemia-waldenstr-m-s-purpura-hSbuSOrw06
Publisher
American Medical Association
Copyright
Copyright © 1957 American Medical Association. All Rights Reserved.
ISSN
0096-5359
DOI
10.1001/archderm.1957.01550230041007
Publisher site
See Article on Publisher Site

Abstract

Abstract Hemorrhagic disturbances may be classified in four groups on the basis of their presumptive pathogenetic mechanism as follows: (1) those due to a primary defect of the vascular wall; (2) those due to a qualitative or quantitative platelet deficiency; (3) those due to abnormalities in the blood coagulation factors, and (4) those due to qualitative or quantitative disturbances of the blood proteins (dysproteinemias).19 Related to the last group, Waldenström16 described a new syndrome, namely "purpura hyperglobulinemica," characterized by relapsing purpura of the lower extremities, persistent increase of the serum-globulin fraction, mild normochromic anemia, leukopenia, elevated erythrosedimentation rate (E. S. R.) and increased total serum proteins between 8.7 and 9.8 gm. per 100 cc. Waldenström performed electrophoretic studies on the three original patients and four additional cases.17,18 These studies disclosed the following: The hyperglobulinemia was due to an increase of References 1. Dr. Rein died May 15, 1957. 2. Apitz, K.: Die Paraproteinosen (Über die Störung des Eiweisstoffwechsels bei Plasmocytom) , Arch. path. Anat. 306:631, 1940.Crossref 3. Curtz, F. R.: Purpura Hyperglobulinaemica , Ugesk. læger , 108:340, 1946. 4. Dorken, H.: Primäre und sekundäre Purpura hyperglobulinaemica , Acta haemat. 10:340, 1953.Crossref 5. Fallet, G. H., and Haenni, A.: A propos d'un nouveau cas de purpura hyperglobulinémique de Waldenstroem , Praxis 43:71, 1954. 6. Horster, J. A.: Purpura hyperglobulinaemica (morphologische Besonderheiten und pathogenetische Untersuchungen) , Acta haemat. 4:201, 1950.Crossref 7. Humerfelt, S.: Purpura with Hyperglobulinemia , Nord. med. 34:1101, 1947. 8. Kay, H. E. M., and Robertson, K. M.: Benign Hyperglobulinaemic Purpura , J. Path. & Bact. 70:543, 1955. 9. Lindeboom, G. A.: Purpura Hyperglobulinemica , Dermatologica 96:337, 1948. 10. Linke, A.: Primäre und sekundäre Dysproteinämie mit Purpura- und Raynaud-Syndrom , Arch. Dermat. u. Syph. 191:123, 1950. 11. Oberste-Lehn, H.: Ein Fall von Purpura hyperglobulinaemica unter dem Bilde der Schambergschen Erkrankung , Zentralbl. Haut- u. Geschlechtskr. 7:404, 1949-1950. 12. Schmengler, F. E., and Esser, H.: Zur Pathogenese der Purpura hyperglobulinaemica , Klin. Wchnschr. 30:30, 1952. 13. Seiden, G. E., and Wurzel, H. A.: Idiopathic Benign Hyperglobulinemic Purpura , New England J. Med. 255:170, 1956. 14. Stefanini, M., and Dameshek, W.: The Hemorrhagic Disorders , New York, Grune & Stratton, Inc., 1955, p. 235. 15. Taylor, F. E., and Battle, J. D.: Benign Hyperglobulinemic Purpura: Case Report , Ann. Int. Med. 40:350, 1954. 16. Vannuchi, V., and Doni, A.: A proposito di un caso di porpora iperglobulinemica , Riv. crit. clin. med. 54:4, 1954. 17. Waldrenström, J.: Clinical Methods for Determination of Hyperproteinemia and Their Practical Value for Diagnosis; Contribution to Study of Essential High Sedimentation Reaction , Nord. med. 20:2288, 1943. 18. Waldenström, J.: Zwei interessante Syndrome mit Hyperglobulinämie (Purpura Hyperglobulinaemica und Makroglobulinämie) , Schweiz. Med. Wchnschr. 78:927, 1948. 19. Waldenström, J.: Three New Cases of Purpura Hyperglobulinemica: A Study in Long Lasting Increase in Serum Globulin , Acta med. scandinav. ( (Supp. 226) ) 142:931, 1952. 20. Wuhrmann, F., and Wunderly, C.: Las proteinas sanguineas en el hombre , Editorial cientifico médica, Madrid, 1949.

Journal

A.M.A. Archives of DermatologyAmerican Medical Association

Published: Nov 1, 1957

References