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PURPURA HAEMORRHAGICA DUE TO INGESTION OF SEDORMID (ALLYLISOPROPYLACETYLCARBAMIDE): EXPERIMENTAL OBSERVATIONS AND REPORT OF A CASE

PURPURA HAEMORRHAGICA DUE TO INGESTION OF SEDORMID (ALLYLISOPROPYLACETYLCARBAMIDE): EXPERIMENTAL... Abstract In 1933, Dennig1 reported 3 cases of purpura haemorrhagica due to oral administration of iodifix, a preparation containing iodine. One of the patients, a woman aged 64, after recovery from iodine purpura had two distinct relapses, each following the use of 1 tablet of sedormid (allylisopropylacetylcarbamide), a drug that she had not used previously. From 1933 to October 1938 reports of instances of purpura haemorrhagica following the use of sedormid2 appeared in rapidly increasing numbers, as evidenced by our having found, in the literature covering this period of approximately five years, reports of 41 cases. Including our reported case, the total number of cases at the time of writing (November 1938) is 42. We have prepared a table (table 1) setting forth the names of the authors and their reports of cases during the period mentioned. Pertinent data in connection with these published cases have been tabulated for References 1. Dennig, H.: Thrombopenische Purpura nach Jodeinnahme , München. med. Wchnschr. 80:562 ( (April 14) ) 1933. 2. Loewy, F. E.: Thrombopenic Haemorrhagic Purpura Due to Idiosyncrasy Towards the Hypnotic Sedormid: Allergotoxic Effect , Lancet 1:845 ( (April 21) ) 1934.Crossref 3. Graubner, W., cited by Hadorn.2i 4. Stern, R.: Psychose bei Purpura cerebri infolge Sedormidüberempfindlichkeit , Wien. klin. Wchnschr. 49:1288 ( (Oct. 16) ) 1936. 5. Falta, W.: Fall von Sedormidpurpura , Wien. klin. Wchnschr. 49: 798 ( (July 19) ) 1936. 6. König, F., in discussion on Falta.2d 7. Decastello, A., in discussion on Falta.2d 8. Glasz, E., in discussion on Falta.2d 9. Pollacsek, K. F., in discussion on Falta.2d 10. Hadorn, W.: Purpura thrombopenica durch Sedormid , Schweiz. med. Wchnschr. 17:1273 ( (Dec. 12) ) 1936. 11. Vogl, A.: Thrombopenische Purpura nach Sedormidgebrauch , Wien. klin. Wchnschr. 48: 908 ( (July 5) ) 1935. 12. von Lauda, E., in discussion on Vogl, A.: Die Pathogenese der akuten thrombopenischen Purpura , Wien. med. Wchnschr. 86:1118 ( (Oct. 3) ) 1936. 13. Boas, E. P., and Erf, L. A.: Thrombocytopenic Purpura Following Medication with Sedormid (Ureide Preparation) and with Phenobarbital , New York State J. Med. 36:491 ( (April 1) ) 1936. 14. Peck, S. M.; Rosenthal, N., and Erf, L. A.: Value of Prognostic Venom Reaction in Thrombocytopenic Purpura , J. A. M. A. 106:1783 ( (May 23) ) 1936.Crossref 15. Mettier, S. R., and Stone, R. S.: Effect of Roentgen Ray Irradiation on Platelet Production in Patients with Essential Thrombocytopenic Purpura Haemorrhagica , Am. J. M. Sc. 191: 794 ( (June) ) 1936.Crossref 16. van Andel, P., and Groen, J.: Thrombopenic Purpura (Werlhof's Disease) After Use of Sedormid , Nederl. tijdschr. v. geneesk. 81: 3348 ( (July 10) ) 1937. 17. Kramer, P. H.: Purpura Hemorrhagica After Use of Sedormid , Nederl. tijdschr. v. geneesk. 81:3345 ( (July 10) ) 1937. 18. Lieberherr, W.: Zur Kenntnis der Purpura thrombocytopenica beim Bebrauch von Sedormid , Med. Klin. 33:475 ( (April 2) ) 1937. 19. Hoffman, A. M.; Kahn, J., and Fitzgibbon, J. P.: Thrombocytopenic Purpura Following Allyl-Isopropyl-Acetyl-Carbamide (Sedormid) , J. A. M. A. 110:725 ( (March 5) ) 1938.Crossref 20. Moody, A. M.: Thrombocytopenic Purpura Following Use of Allyl-Isopropyl-Acetyl-Carbamide (Sedormid) , J. A. M. A. 110:726 ( (March 5) ) 1938.Crossref 21. Torrens, J.: Purpura Following Sedormid , Lancet 1:749 ( (March 26) ) 1938. 22. Joekes, T.: Purpura Haemorrhagica (Werlhof's) After Taking Sedormid , Lancet 2:305 ( (Aug. 6) ) 1938.Crossref 23. Hill, D. B.: Thrombopenic Purpura Following Allyl-Isopropyl-Acetyl-Carbamide (Sedormid) , J. A. M. A. 111:1459 ( (Oct. 15) ) 1938.Crossref 24. Naegeli, O.: Differentialdiagnose in der inneren Medizin , ed. 2, Leipzig, Georg Thieme, 1936 25. cited by Joekes.2u Dennig.1 26. Squier, T. L., and Madison, F. W.: Primary Granulocytopenia Due to Hypersensitivity to Amidopyrine , J. Allergy 6:9 ( (Nov.) ) 1934.Crossref 27. Squier, T. L., and Madison, F. W.: The Hematologic Response in Food Allergy Eosinophilia in the Leucopenic Index , J. Allergy 8:250 ( (March) ) 1937Crossref 28. Thrombocytopenic Purpura Due to Food Allergy , Squier J. Allergy 8:143 ( (Jan.) ) 1937.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Internal Medicine American Medical Association

PURPURA HAEMORRHAGICA DUE TO INGESTION OF SEDORMID (ALLYLISOPROPYLACETYLCARBAMIDE): EXPERIMENTAL OBSERVATIONS AND REPORT OF A CASE

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Publisher
American Medical Association
Copyright
Copyright © 1940 American Medical Association. All Rights Reserved.
ISSN
0730-188X
DOI
10.1001/archinte.1940.00190070132009
Publisher site
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Abstract

Abstract In 1933, Dennig1 reported 3 cases of purpura haemorrhagica due to oral administration of iodifix, a preparation containing iodine. One of the patients, a woman aged 64, after recovery from iodine purpura had two distinct relapses, each following the use of 1 tablet of sedormid (allylisopropylacetylcarbamide), a drug that she had not used previously. From 1933 to October 1938 reports of instances of purpura haemorrhagica following the use of sedormid2 appeared in rapidly increasing numbers, as evidenced by our having found, in the literature covering this period of approximately five years, reports of 41 cases. Including our reported case, the total number of cases at the time of writing (November 1938) is 42. We have prepared a table (table 1) setting forth the names of the authors and their reports of cases during the period mentioned. Pertinent data in connection with these published cases have been tabulated for References 1. Dennig, H.: Thrombopenische Purpura nach Jodeinnahme , München. med. Wchnschr. 80:562 ( (April 14) ) 1933. 2. Loewy, F. E.: Thrombopenic Haemorrhagic Purpura Due to Idiosyncrasy Towards the Hypnotic Sedormid: Allergotoxic Effect , Lancet 1:845 ( (April 21) ) 1934.Crossref 3. Graubner, W., cited by Hadorn.2i 4. Stern, R.: Psychose bei Purpura cerebri infolge Sedormidüberempfindlichkeit , Wien. klin. Wchnschr. 49:1288 ( (Oct. 16) ) 1936. 5. Falta, W.: Fall von Sedormidpurpura , Wien. klin. Wchnschr. 49: 798 ( (July 19) ) 1936. 6. König, F., in discussion on Falta.2d 7. Decastello, A., in discussion on Falta.2d 8. Glasz, E., in discussion on Falta.2d 9. Pollacsek, K. F., in discussion on Falta.2d 10. Hadorn, W.: Purpura thrombopenica durch Sedormid , Schweiz. med. Wchnschr. 17:1273 ( (Dec. 12) ) 1936. 11. Vogl, A.: Thrombopenische Purpura nach Sedormidgebrauch , Wien. klin. Wchnschr. 48: 908 ( (July 5) ) 1935. 12. von Lauda, E., in discussion on Vogl, A.: Die Pathogenese der akuten thrombopenischen Purpura , Wien. med. Wchnschr. 86:1118 ( (Oct. 3) ) 1936. 13. Boas, E. P., and Erf, L. A.: Thrombocytopenic Purpura Following Medication with Sedormid (Ureide Preparation) and with Phenobarbital , New York State J. Med. 36:491 ( (April 1) ) 1936. 14. Peck, S. M.; Rosenthal, N., and Erf, L. A.: Value of Prognostic Venom Reaction in Thrombocytopenic Purpura , J. A. M. A. 106:1783 ( (May 23) ) 1936.Crossref 15. Mettier, S. R., and Stone, R. S.: Effect of Roentgen Ray Irradiation on Platelet Production in Patients with Essential Thrombocytopenic Purpura Haemorrhagica , Am. J. M. Sc. 191: 794 ( (June) ) 1936.Crossref 16. van Andel, P., and Groen, J.: Thrombopenic Purpura (Werlhof's Disease) After Use of Sedormid , Nederl. tijdschr. v. geneesk. 81: 3348 ( (July 10) ) 1937. 17. Kramer, P. H.: Purpura Hemorrhagica After Use of Sedormid , Nederl. tijdschr. v. geneesk. 81:3345 ( (July 10) ) 1937. 18. Lieberherr, W.: Zur Kenntnis der Purpura thrombocytopenica beim Bebrauch von Sedormid , Med. Klin. 33:475 ( (April 2) ) 1937. 19. Hoffman, A. M.; Kahn, J., and Fitzgibbon, J. P.: Thrombocytopenic Purpura Following Allyl-Isopropyl-Acetyl-Carbamide (Sedormid) , J. A. M. A. 110:725 ( (March 5) ) 1938.Crossref 20. Moody, A. M.: Thrombocytopenic Purpura Following Use of Allyl-Isopropyl-Acetyl-Carbamide (Sedormid) , J. A. M. A. 110:726 ( (March 5) ) 1938.Crossref 21. Torrens, J.: Purpura Following Sedormid , Lancet 1:749 ( (March 26) ) 1938. 22. Joekes, T.: Purpura Haemorrhagica (Werlhof's) After Taking Sedormid , Lancet 2:305 ( (Aug. 6) ) 1938.Crossref 23. Hill, D. B.: Thrombopenic Purpura Following Allyl-Isopropyl-Acetyl-Carbamide (Sedormid) , J. A. M. A. 111:1459 ( (Oct. 15) ) 1938.Crossref 24. Naegeli, O.: Differentialdiagnose in der inneren Medizin , ed. 2, Leipzig, Georg Thieme, 1936 25. cited by Joekes.2u Dennig.1 26. Squier, T. L., and Madison, F. W.: Primary Granulocytopenia Due to Hypersensitivity to Amidopyrine , J. Allergy 6:9 ( (Nov.) ) 1934.Crossref 27. Squier, T. L., and Madison, F. W.: The Hematologic Response in Food Allergy Eosinophilia in the Leucopenic Index , J. Allergy 8:250 ( (March) ) 1937Crossref 28. Thrombocytopenic Purpura Due to Food Allergy , Squier J. Allergy 8:143 ( (Jan.) ) 1937.Crossref

Journal

Archives of Internal MedicineAmerican Medical Association

Published: Jan 1, 1940

References