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PSYCHOSIS OCCURRING DURING ANTABUSE ADMINISTRATION

PSYCHOSIS OCCURRING DURING ANTABUSE ADMINISTRATION Abstract PREVIOUS reports on the administration of tetraethylthiuramdisulfide (antabuse®) have listed various symptoms which commonly occur in patients who are taking the drug.1 These symptoms have been found to be fatigue, headache, dizziness, gastrointestinal disturbances, skin allergies, unpleasant taste in the mouth and reduced sexual potency. Psychosis also has been reported as a complication of tetraethylthiuramdisulfide therapy. Lemieux2 mentioned two patients in whom manic-like reactions developed. One patient's disturbance cleared after withdrawal of the drug; the other's, after reduction of the dose. Bennett, McKeever, and Turk,3 in reporting six cases of psychosis complicating tetraethylthiuramdisulfide therapy, noted a predominant paranoid reaction in two and an expansive trend in one; discontinuance of the drug was necessary with five of the patients; but of these, all had evidence of hepatic damage, and four, symptoms of organic damage to the brain, prior to treatment with tetraethylthiuramdisulfide. Knutsen4 reported the case of References 1. Glud, E.: The Treatment of Alcoholic Patients in Denmark with "Antabuse®" with Suggestions for its Trial in the United States , Quart. Stud. Alcohol 10:185, 1949. 2. Gelbman, F., and Epstein, H. B.: Initial Clinical Experience with Antabuse,® Canad. M. A. J. 60:549, 1949. 3. Bell, R. G., and Smith, H. W.: Preliminary Report on Clinical Trials of Antabuse,® Canad. M. A. J. 60:286, 1949. 4. Barrera, S. E.; Osinski, W. A., and Davidoff, E.: The Use of Antabuse® (Tetraethylthiuramdisulphide) in Chronic Alcoholics , Am. J. Psychiat. 107:8, 1950. 5. Lemieux, L. H.: L'alcoolisme chronique et ses traitements , Laval méd. 14:1304, 1949. 6. Bennett, A. E.; McKeever, L. G., and Turk, R. E.: Psychotic Reactions During Tetraethylthiuramdisulfide (Antabuse®) Therapy , J. A. M. A. 145:483 ( (Feb. 17) ) 1951.Crossref 7. Knutsen, B.: Komplikasjoner ved antabus®-behandling , Tidsskr. norske lægefor. 69:436, 1949. 8. Footnote 1. 9. Knutsen.4 10. Hald, J., and Jacobsen, E.: A Drug Sensitizing the Organism to Ethyl Alcohol , Lancet 2:1001, 1948.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png A.M.A. Archives of Neurology & Psychiatry American Medical Association

PSYCHOSIS OCCURRING DURING ANTABUSE ADMINISTRATION

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Publisher
American Medical Association
Copyright
Copyright © 1951 American Medical Association. All Rights Reserved.
ISSN
0096-6886
DOI
10.1001/archneurpsyc.1951.02320070058004
Publisher site
See Article on Publisher Site

Abstract

Abstract PREVIOUS reports on the administration of tetraethylthiuramdisulfide (antabuse®) have listed various symptoms which commonly occur in patients who are taking the drug.1 These symptoms have been found to be fatigue, headache, dizziness, gastrointestinal disturbances, skin allergies, unpleasant taste in the mouth and reduced sexual potency. Psychosis also has been reported as a complication of tetraethylthiuramdisulfide therapy. Lemieux2 mentioned two patients in whom manic-like reactions developed. One patient's disturbance cleared after withdrawal of the drug; the other's, after reduction of the dose. Bennett, McKeever, and Turk,3 in reporting six cases of psychosis complicating tetraethylthiuramdisulfide therapy, noted a predominant paranoid reaction in two and an expansive trend in one; discontinuance of the drug was necessary with five of the patients; but of these, all had evidence of hepatic damage, and four, symptoms of organic damage to the brain, prior to treatment with tetraethylthiuramdisulfide. Knutsen4 reported the case of References 1. Glud, E.: The Treatment of Alcoholic Patients in Denmark with "Antabuse®" with Suggestions for its Trial in the United States , Quart. Stud. Alcohol 10:185, 1949. 2. Gelbman, F., and Epstein, H. B.: Initial Clinical Experience with Antabuse,® Canad. M. A. J. 60:549, 1949. 3. Bell, R. G., and Smith, H. W.: Preliminary Report on Clinical Trials of Antabuse,® Canad. M. A. J. 60:286, 1949. 4. Barrera, S. E.; Osinski, W. A., and Davidoff, E.: The Use of Antabuse® (Tetraethylthiuramdisulphide) in Chronic Alcoholics , Am. J. Psychiat. 107:8, 1950. 5. Lemieux, L. H.: L'alcoolisme chronique et ses traitements , Laval méd. 14:1304, 1949. 6. Bennett, A. E.; McKeever, L. G., and Turk, R. E.: Psychotic Reactions During Tetraethylthiuramdisulfide (Antabuse®) Therapy , J. A. M. A. 145:483 ( (Feb. 17) ) 1951.Crossref 7. Knutsen, B.: Komplikasjoner ved antabus®-behandling , Tidsskr. norske lægefor. 69:436, 1949. 8. Footnote 1. 9. Knutsen.4 10. Hald, J., and Jacobsen, E.: A Drug Sensitizing the Organism to Ethyl Alcohol , Lancet 2:1001, 1948.Crossref

Journal

A.M.A. Archives of Neurology & PsychiatryAmerican Medical Association

Published: Jul 1, 1951

References