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Psoriatic Angiogenic Factor: Evidence for Its Existence

Psoriatic Angiogenic Factor: Evidence for Its Existence Abstract To the Editor.— Folkman1 suggested the existence of an angiogenic factor in psoriasis. This concept was predicated on the similarity between psoriasis and tumors.Tumor angiogenic factor (TAF) had first been described by Folkman et al2 as the results of experiments with tissue culture. Subsequently, in animal experiments, Wolf and Harrison3 showed the existence of an epidermal angiogenic factor similar to TAF.Rapp et al4 and Glickman et al5 studied the evolution of vascular changes in induced and naturally occurring inflammation in the skin by means of the technique of capillary microscopy. Several stages in the inflammatory process, as reflected by the microvessels in the living human skin were described. These included (1) vasodilation: (2) vascular damage, characterized by the development of microaneurysms and extravasation of red blood cells; (3) proliferation, characterized by the appearance of arborization patterns at the terminal capillary loops, increasing the References 1. Folkman J: Angiogenesis in psoriasis, therapeutic implications . J Invest Dermatol 59:40-43, 1972.Crossref 2. Folkman J, Merler E, Abernathy C, et al: Isolation of a tumor extract responsible for angiogenesis . J Exp Med 133:275-288, 1971.Crossref 3. Wolf JE, Harrison RG: Demonstration and characterization of an epidermal angiogenic factor . J Invest Dermatol 61:130-141, 1973.Crossref 4. Rapp Y, Glickman FS, Frank L: Capillary microscopy in induced skin inflammation . Arch Dermatol 88:257-266, 1963.Crossref 5. Glickman FS, Rapp Y, Frank L: Capillary microscopy in inflammatory dermatoses . Arch Dermatol 90:500-505, 1964.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Dermatology American Medical Association

Psoriatic Angiogenic Factor: Evidence for Its Existence

Archives of Dermatology , Volume 112 (12) – Dec 1, 1976

Psoriatic Angiogenic Factor: Evidence for Its Existence

Abstract

Abstract To the Editor.— Folkman1 suggested the existence of an angiogenic factor in psoriasis. This concept was predicated on the similarity between psoriasis and tumors.Tumor angiogenic factor (TAF) had first been described by Folkman et al2 as the results of experiments with tissue culture. Subsequently, in animal experiments, Wolf and Harrison3 showed the existence of an epidermal angiogenic factor similar to TAF.Rapp et al4 and Glickman et al5 studied the evolution of vascular...
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Publisher
American Medical Association
Copyright
Copyright © 1976 American Medical Association. All Rights Reserved.
ISSN
0003-987X
eISSN
1538-3652
DOI
10.1001/archderm.1976.01630370069018
Publisher site
See Article on Publisher Site

Abstract

Abstract To the Editor.— Folkman1 suggested the existence of an angiogenic factor in psoriasis. This concept was predicated on the similarity between psoriasis and tumors.Tumor angiogenic factor (TAF) had first been described by Folkman et al2 as the results of experiments with tissue culture. Subsequently, in animal experiments, Wolf and Harrison3 showed the existence of an epidermal angiogenic factor similar to TAF.Rapp et al4 and Glickman et al5 studied the evolution of vascular changes in induced and naturally occurring inflammation in the skin by means of the technique of capillary microscopy. Several stages in the inflammatory process, as reflected by the microvessels in the living human skin were described. These included (1) vasodilation: (2) vascular damage, characterized by the development of microaneurysms and extravasation of red blood cells; (3) proliferation, characterized by the appearance of arborization patterns at the terminal capillary loops, increasing the References 1. Folkman J: Angiogenesis in psoriasis, therapeutic implications . J Invest Dermatol 59:40-43, 1972.Crossref 2. Folkman J, Merler E, Abernathy C, et al: Isolation of a tumor extract responsible for angiogenesis . J Exp Med 133:275-288, 1971.Crossref 3. Wolf JE, Harrison RG: Demonstration and characterization of an epidermal angiogenic factor . J Invest Dermatol 61:130-141, 1973.Crossref 4. Rapp Y, Glickman FS, Frank L: Capillary microscopy in induced skin inflammation . Arch Dermatol 88:257-266, 1963.Crossref 5. Glickman FS, Rapp Y, Frank L: Capillary microscopy in inflammatory dermatoses . Arch Dermatol 90:500-505, 1964.Crossref

Journal

Archives of DermatologyAmerican Medical Association

Published: Dec 1, 1976

References