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Psoriasis, Methotrexate, and Oligospermia

Psoriasis, Methotrexate, and Oligospermia Abstract • A young man with severe psoriasis was treated intermittently with methotrexate. On two different occasions, severe oligospermia documented by serial seminal fluid analyses was present coincident with methotrexate administration. Discontinuation of methotrexate resulted in normal sperm concentration. Measurements of serum gonadotrophin and testosterone levels were normal during and after methotrexate treatment. It is concluded that methotrexate administration may result in severe oligospermia and that these inhibiting effects on spermatogenesis are reversible. (Arch Dermatol 116:215-217, 1980) References 1. Weinstein GD: Methotrexate . Ann Intern Med 86:199-204, 1977.Crossref 2. Gunther VE: Andrologische Untersuchungen bei der antimetabolite Therapie der Psoriasis . Dermatol Monatsschr 156:498-502, 1970. 3. Van Scott EJ, Reinertson RP: Morphologic and physiologic effects of chemotherapeutic agents in psoriasis . J Invest Dermatol 33:357-369, 1959.Crossref 4. DeLuca M, Ciampo E, Rossi A: Studio del liquido seminale in soggetti trattati con methotrexate . G Ital Dermatol 46:247-249, 1971. 5. Grunnet E, Nyfors A, Hansen K: Studies on human semen in topical corticosteroid-treated and in methotrexate-treated psoriatics . Dermatologica 154:78-84, 1977.Crossref 6. Gordon DH, Moore D, Thorslund T, et al: The determination of size and concentration of human sperm with an electronic particle counter . J Lab Clin Med 65:506-512, 1965. 7. Couture M, Ulstein M, Leonard JM, et al: Improved staining method for differentiating immature germ cells from white blood cells in human seminal fluid . Andrologia 8:61-66, 1976.Crossref 8. MacLeod J: The significance of deviations in human sperm morphology , in Rosemberg E, Paulsen CA (eds): The Human Testis . New York, Plenum Press Inc, 1970, 481-492. 9. Midgley AR Jr: Radioimmunoassay: A method for human chorionic gonadotropin and human luteinizing hormone . Endocrinology 79:10-18, 1966.Crossref 10. Nieschlag E, Loriaux DL: Radioimmunoassay for plasma testosterone . Z Klin Chem Klin Biochem 4:164, 1972. 11. Heller CG, Clermont Y: Kinetics of the germinal epithelium in man . Recent Prog Horm Res 20:545-575, 1964. 12. Fox BW, Fox M: Biochemical aspects of the actions of drugs on spermatogenesis . Pharmacol Rev 19:21-57, 1967. 13. Lipsett MB, Sherins R: The testis , in Bondy PK, Rosenberg L (eds): Duncan's Disease of Metabolism , ed 7. Philadelphia, WB Saunders Co, 1974, pp 1553-1584. 14. Sherins RJ, Brightwell D, Stenthal PM: Longitudinal analysis of semen of fertile and infertile man , in Troen P, Nankin HR (eds): The Testis in Normal and Infertile Man . New York, Raven Press, 1977, pp 473-488. 15. Freeman-Narrod M, Narrod SA: Chronic toxicity of methotrexate in mice . Natl Cancer Inst 58:735-740, 1977. 16. Rees RB, Bennett JH, Maibach HI, et al: Methotrexate for psoriasis . Arch Dermatol 95:2-10, 1967.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Dermatology American Medical Association

Psoriasis, Methotrexate, and Oligospermia

Archives of Dermatology , Volume 116 (2) – Feb 1, 1980

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Publisher
American Medical Association
Copyright
Copyright © 1980 American Medical Association. All Rights Reserved.
ISSN
0003-987X
eISSN
1538-3652
DOI
10.1001/archderm.1980.01640260091025
Publisher site
See Article on Publisher Site

Abstract

Abstract • A young man with severe psoriasis was treated intermittently with methotrexate. On two different occasions, severe oligospermia documented by serial seminal fluid analyses was present coincident with methotrexate administration. Discontinuation of methotrexate resulted in normal sperm concentration. Measurements of serum gonadotrophin and testosterone levels were normal during and after methotrexate treatment. It is concluded that methotrexate administration may result in severe oligospermia and that these inhibiting effects on spermatogenesis are reversible. (Arch Dermatol 116:215-217, 1980) References 1. Weinstein GD: Methotrexate . Ann Intern Med 86:199-204, 1977.Crossref 2. Gunther VE: Andrologische Untersuchungen bei der antimetabolite Therapie der Psoriasis . Dermatol Monatsschr 156:498-502, 1970. 3. Van Scott EJ, Reinertson RP: Morphologic and physiologic effects of chemotherapeutic agents in psoriasis . J Invest Dermatol 33:357-369, 1959.Crossref 4. DeLuca M, Ciampo E, Rossi A: Studio del liquido seminale in soggetti trattati con methotrexate . G Ital Dermatol 46:247-249, 1971. 5. Grunnet E, Nyfors A, Hansen K: Studies on human semen in topical corticosteroid-treated and in methotrexate-treated psoriatics . Dermatologica 154:78-84, 1977.Crossref 6. Gordon DH, Moore D, Thorslund T, et al: The determination of size and concentration of human sperm with an electronic particle counter . J Lab Clin Med 65:506-512, 1965. 7. Couture M, Ulstein M, Leonard JM, et al: Improved staining method for differentiating immature germ cells from white blood cells in human seminal fluid . Andrologia 8:61-66, 1976.Crossref 8. MacLeod J: The significance of deviations in human sperm morphology , in Rosemberg E, Paulsen CA (eds): The Human Testis . New York, Plenum Press Inc, 1970, 481-492. 9. Midgley AR Jr: Radioimmunoassay: A method for human chorionic gonadotropin and human luteinizing hormone . Endocrinology 79:10-18, 1966.Crossref 10. Nieschlag E, Loriaux DL: Radioimmunoassay for plasma testosterone . Z Klin Chem Klin Biochem 4:164, 1972. 11. Heller CG, Clermont Y: Kinetics of the germinal epithelium in man . Recent Prog Horm Res 20:545-575, 1964. 12. Fox BW, Fox M: Biochemical aspects of the actions of drugs on spermatogenesis . Pharmacol Rev 19:21-57, 1967. 13. Lipsett MB, Sherins R: The testis , in Bondy PK, Rosenberg L (eds): Duncan's Disease of Metabolism , ed 7. Philadelphia, WB Saunders Co, 1974, pp 1553-1584. 14. Sherins RJ, Brightwell D, Stenthal PM: Longitudinal analysis of semen of fertile and infertile man , in Troen P, Nankin HR (eds): The Testis in Normal and Infertile Man . New York, Raven Press, 1977, pp 473-488. 15. Freeman-Narrod M, Narrod SA: Chronic toxicity of methotrexate in mice . Natl Cancer Inst 58:735-740, 1977. 16. Rees RB, Bennett JH, Maibach HI, et al: Methotrexate for psoriasis . Arch Dermatol 95:2-10, 1967.Crossref

Journal

Archives of DermatologyAmerican Medical Association

Published: Feb 1, 1980

References