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Psoralen Plus UV-A-Associated Skin Cancer: A Likely Role for Human Papillomavirus Type 16?

Psoralen Plus UV-A-Associated Skin Cancer: A Likely Role for Human Papillomavirus Type 16? Abstract Weinstock et al1 found human papillomavirus (HPV) (type 16 or a closely related type) in 22 of 30 skin lesions in a single patient in whom multiple skin cancers developed after prolonged therapy with psoralen plus UV-A (PUVA). Although this is an interesting observation, the question remains whether HPV-16 had a functional role in the development of these tumors. Several lines of evidence suggest that HPV-16 is unlikely to play a role in the development of skin cancer in most patients, immunosuppressed or not. The HPVs are highly host specific and show a remarkable degree of tissue specificity. Common mucosalassociated HPV types, including 16 and 18, are rarely found in keratinizing epithelia, even in chronically immunosuppressed renal transplant recipients, and, similarly, cutaneous HPV types are not found in the genital tract. Instead, recent studies implicate novel epidermodysplasia verruciformis—related cutaneous HPVs in the development of transplant-associated skin cancers2,3 found References 1. Weinstock MA, Coulter S, Bates J, et al. Human papillomavirus and wide-spread cutaneous carcinoma after PUVA photochemotherapy . Arch Dermatol. 1995;131:701-704.Crossref 2. Shamanin V, Glover M, Rausch C, et al. Specific types of human papillomavirus found in benign proliferations and carcinomas of the skin in immunosuppressed patients . Cancer Res. 1994;54:4610-4613. 3. Berkhout RJM, Tieben LM, Smits HL, Bouwes Bavincke JN, Vermeer BJ, ter Scheggert J. Detection and typing of epidermodysplasia verruciformis-associated human papillomavirus types in cutaneous cancers from renal transplant recipients: a nested approach . J Clin Microbiol. 1995;33:690-695. 4. Crook T, Wrede D, Tidy J, Scholefield J, Crawford L, Vousden KH. Status of c-myc, p53 and retinoblastomas genes in human papillomavirus positive and negative squamous cell carcinoma of the anus . Oncogene. 1991;6:1251-1257. 5. Proby CM, Menage H, McGregor JM, et al. p53 Immunoreactivity in cutaneous PUVA tumours is similar to that in other non-melanoma skin neoplasms . J Cutan Pathol. 1993;20:435-441.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Dermatology American Medical Association

Psoralen Plus UV-A-Associated Skin Cancer: A Likely Role for Human Papillomavirus Type 16?

Psoralen Plus UV-A-Associated Skin Cancer: A Likely Role for Human Papillomavirus Type 16?

Abstract

Abstract Weinstock et al1 found human papillomavirus (HPV) (type 16 or a closely related type) in 22 of 30 skin lesions in a single patient in whom multiple skin cancers developed after prolonged therapy with psoralen plus UV-A (PUVA). Although this is an interesting observation, the question remains whether HPV-16 had a functional role in the development of these tumors. Several lines of evidence suggest that HPV-16 is unlikely to play a role in the development of skin cancer in most...
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Publisher
American Medical Association
Copyright
Copyright © 1996 American Medical Association. All Rights Reserved.
ISSN
0003-987X
eISSN
1538-3652
DOI
10.1001/archderm.1996.03890250104019
Publisher site
See Article on Publisher Site

Abstract

Abstract Weinstock et al1 found human papillomavirus (HPV) (type 16 or a closely related type) in 22 of 30 skin lesions in a single patient in whom multiple skin cancers developed after prolonged therapy with psoralen plus UV-A (PUVA). Although this is an interesting observation, the question remains whether HPV-16 had a functional role in the development of these tumors. Several lines of evidence suggest that HPV-16 is unlikely to play a role in the development of skin cancer in most patients, immunosuppressed or not. The HPVs are highly host specific and show a remarkable degree of tissue specificity. Common mucosalassociated HPV types, including 16 and 18, are rarely found in keratinizing epithelia, even in chronically immunosuppressed renal transplant recipients, and, similarly, cutaneous HPV types are not found in the genital tract. Instead, recent studies implicate novel epidermodysplasia verruciformis—related cutaneous HPVs in the development of transplant-associated skin cancers2,3 found References 1. Weinstock MA, Coulter S, Bates J, et al. Human papillomavirus and wide-spread cutaneous carcinoma after PUVA photochemotherapy . Arch Dermatol. 1995;131:701-704.Crossref 2. Shamanin V, Glover M, Rausch C, et al. Specific types of human papillomavirus found in benign proliferations and carcinomas of the skin in immunosuppressed patients . Cancer Res. 1994;54:4610-4613. 3. Berkhout RJM, Tieben LM, Smits HL, Bouwes Bavincke JN, Vermeer BJ, ter Scheggert J. Detection and typing of epidermodysplasia verruciformis-associated human papillomavirus types in cutaneous cancers from renal transplant recipients: a nested approach . J Clin Microbiol. 1995;33:690-695. 4. Crook T, Wrede D, Tidy J, Scholefield J, Crawford L, Vousden KH. Status of c-myc, p53 and retinoblastomas genes in human papillomavirus positive and negative squamous cell carcinoma of the anus . Oncogene. 1991;6:1251-1257. 5. Proby CM, Menage H, McGregor JM, et al. p53 Immunoreactivity in cutaneous PUVA tumours is similar to that in other non-melanoma skin neoplasms . J Cutan Pathol. 1993;20:435-441.Crossref

Journal

Archives of DermatologyAmerican Medical Association

Published: Jan 1, 1996

References