Opinion EDITORIAL Psilocybin-Assisted Supportive Psychotherapy in the Treatment of Major Depression—Quo Vadis? Charles F. Reynolds III, MD In this issue of JAMA Psychiatry, Davis and colleagues at Take a step back for a moment and recall the etymology the Johns Hopkins Center for Psychedelic and Conscious- of psychedelic, a term derived from 2 Greek words, psyche (meaning soul, spirit, or mind) and delos (meaning clear or ness Research have contributed a timely and important proof-of-concept randomized clinical trial on the effects of manifest). With respect to the metaphors that we live by, the psilocybin-assisted support- psychedelic experience has been analogized to a psychologi- ive psychotherapy for the cal journey, which in the current treatment model is a jour- Related article treatment of major depres- ney accompanied by a therapist or guide who helps partici- sion. The authors reported rapid relief of depressive pants understand the challenges of the psychedelic experience, symptoms and high rates of response and remission that including issues and insights that might need further psycho- were sustained for more than 4 weeks in a sample of 24 logical integration (and by implication, to sustain antidepres- midlife adults, many of whom had chronic depression. The sant response
JAMA Psychiatry – American Medical Association
Published: Feb 4, 2021
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