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Pseudohypoparathyroidism-Reply

Pseudohypoparathyroidism-Reply Abstract In Reply.—It was very interesting to read about four of five children in a family who had pseudohypoparathyroidism and eventually seemed to develop pseudo-pseudohypoparathyroidism. Our patient had normal levels of calcium and serum inorganic phosphate on several occasions, unlike your patient who had a high level of serum inorganic phosphate. Hypocalcemia and hyperphosphatemia are characteristic of patients with pseudohypoparathyroidism. A complication, particularly of hyperphosphatemia, is the frequent occurrence of soft tissue calcifications. In pseudohypoparathyroidism, the mineral deposits in ectopic sites may include the development of true bone.1 Lack of these findings is consistent with normal levels of serum inorganic phosphate levels in our patient. Our patient failed to show phosphaturic response to parathyroid hormone administration. Bell et al2 have demonstrated that higher doses of parathyroid hormone did cause a rise in serum and urinary calcium levels and in urinary phosphate excretion in patients with pseudohypoparathyroidism. However, the References 1. Potts JT Jr, Deftos LJ: Parathyroid hormone, thyrocalcitonin, vitamin D, bone and mineral metabolism , in Bondy PK, Rosenberg LE (eds): Duncan's Disease of Metabolism , ed 6. Philadelphia, WB Saunders Co, 1969, p 904. 2. Bell NH, Avery S, Sinha T, et al: Effects of dibutyryl cyclic adenosine 3′-5′-monophosphate and parathyroid extract on calcium and phosphorous metabolism in hypoparathyroidism and pseudohypoparathyroidism . J Clin Invest 51:816-823, 1972.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of Diseases of Children American Medical Association

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Publisher
American Medical Association
Copyright
Copyright © 1976 American Medical Association. All Rights Reserved.
ISSN
0002-922X
DOI
10.1001/archpedi.1976.02120080102019
Publisher site
See Article on Publisher Site

Abstract

Abstract In Reply.—It was very interesting to read about four of five children in a family who had pseudohypoparathyroidism and eventually seemed to develop pseudo-pseudohypoparathyroidism. Our patient had normal levels of calcium and serum inorganic phosphate on several occasions, unlike your patient who had a high level of serum inorganic phosphate. Hypocalcemia and hyperphosphatemia are characteristic of patients with pseudohypoparathyroidism. A complication, particularly of hyperphosphatemia, is the frequent occurrence of soft tissue calcifications. In pseudohypoparathyroidism, the mineral deposits in ectopic sites may include the development of true bone.1 Lack of these findings is consistent with normal levels of serum inorganic phosphate levels in our patient. Our patient failed to show phosphaturic response to parathyroid hormone administration. Bell et al2 have demonstrated that higher doses of parathyroid hormone did cause a rise in serum and urinary calcium levels and in urinary phosphate excretion in patients with pseudohypoparathyroidism. However, the References 1. Potts JT Jr, Deftos LJ: Parathyroid hormone, thyrocalcitonin, vitamin D, bone and mineral metabolism , in Bondy PK, Rosenberg LE (eds): Duncan's Disease of Metabolism , ed 6. Philadelphia, WB Saunders Co, 1969, p 904. 2. Bell NH, Avery S, Sinha T, et al: Effects of dibutyryl cyclic adenosine 3′-5′-monophosphate and parathyroid extract on calcium and phosphorous metabolism in hypoparathyroidism and pseudohypoparathyroidism . J Clin Invest 51:816-823, 1972.Crossref

Journal

American Journal of Diseases of ChildrenAmerican Medical Association

Published: Jul 1, 1976

References