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Pseudoexfoliation, Intraocular Pressure, and Senile Lens Changes in a Population-Based Survey

Pseudoexfoliation, Intraocular Pressure, and Senile Lens Changes in a Population-Based Survey Abstract • The prevalence rate of pseudoexfoliation among persons in the Framingham Eye Study, a population-based survey, increased from 0.6% for ages 52 to 64 years to 2.6% for ages 65 to 74 years to 5.0% for ages 75 to 85 years. Age-adjusted rates showed a statistically significant 2.3 to 1.0 female to male ratio. Pseudoexfoliation was associated with higher intraocular pressure levels and more frequent senile lens changes, but the latter relationship was not statistically significant. The age-specific prevalence rates for the Framingham population are similar to those reported from a mass screening of subjects in Norway, where the condition is thought to be especially common. Some of the previously reported geographic variations in prevalence rates may be due to differences in disease definitions, subject selection, and examination conditions. References 1. Duke-Elder S: Diseases of the Lens and Vitreous: Glaucoma and Hypotony , vol 11, in System of Ophthalmology . St Louis, CV Mosby Co, 1969, p 47. 2. Krause U, Helve J, Forsius H: Pseudoexfoliation of the lens capsule and liberation of iris pigment . Acta Ophthalmol 1973;51:39-46.Crossref 3. Petersen HP: Exfoliation of the interior lens capsule without glaucoma . Acta Ophthalmol 1958;36:375-380.Crossref 4. Aasved H: The geographical distribution of fibrillopathia epitheliocapsularis . Acta Ophthalmol 1969;47:792-810.Crossref 5. Taylor HR, Hollows FC, Moran D: Pseudoexfoliation of the lens in Australian aborigines . Br J Ophthalmol 1977;61:473-475.Crossref 6. Forsius H, Eriksson A: Ophthalmological studies of a population group in the Aland Islands . Acta Ophthalmol 1961;39:318-321. 7. Olivius E, Thorburn W: Prognosis of glaucoma simplex and glaucoma capsulare: A comparative study . Acta Ophthalmol 1978;56:921-934.Crossref 8. Aasved H: The frequency of optic nerve damage and surgical treatment in chronic simplex glaucoma and capsular glaucoma . Acta Ophthalmol 1971;49:589-600.Crossref 9. Layden WE, Shaffer RN: Exfoliation syndrome . Trans Am Ophthalmol Soc 1973;71:128-151. 10. Tarkkanen A: Treatment of chronic openangle glaucoma associated with pseudoexfoliation . Acta Ophthalmol 1965;43:514-523.Crossref 11. Taylor HR: Pseudoexfoliation, an environmental disease? Trans Ophthalmol Soc UK 1979;99:302-307. 12. Leibowitz HM, Krueger DE, Maunder LR, et al: The Framingham Eye Study Monograph . Surv Ophthalmol 1980;24( (suppl) ):343-400.Crossref 13. Kahn HA, Leiboweitz HM, Ganley JP, et al: The Framingham Eye Study: I. Outline and major prevalence findings . Am J Epidemiol 1977;106:17-32. 14. Gart JJ: The comparison of proportions: A review of significance tests, confidence intervals and adjustments for stratification . Rev Intern Stat Inst 1971;39:149-169.Crossref 15. Thomas DG: Exact and asymptotic methods for the combination of 2 × 2 tables . Comput Biomed Res 1975;8:423-446.Crossref 16. Mausner JS, Bahn AK: Epidemiology: An Introductory Test . Philadelphia, WB Saunders Co, 1974, pp 316-321. 17. Armitage P: Statistical Methods in Medical Research . New York, John Wiley & Sons Inc, 1971, pp 387-388. 18. Aasved H: Mass screening for fibrillopathia epitheliocapsularis, so-called senile exfoliation or pseudoexfoliation of the anterior lens capsule . Acta Ophthalmol 1971;49:334-343.Crossref 19. Gradle HS, Sugar HS: Glaucoma capsulare . Am J Ophthalmol 1947;30:12-19. 20. Irvine R: Exfoliation of the lens capsule (glaucoma capsularis) . Arch Ophthalmol 1940;23:138-160.Crossref 21. Vogt A: Ein neues Spaltlampenbild des Prysillengebietes: Hellblaner Pupillensaumfilz mit Hautchenbildung auf der Linsennorderkapsil . Klin Monatsbl Augenheilkd 1925;75:1-12. 22. Horven E: Exfoliation of the superficial layer of the lens capsule (Vogt) and its relation to glaucoma simplex . Br J Ophthalmol 1937;21:625-637.Crossref 23. Holst JC: A statistical study of glaucoma . Am J Ophthalmol 1947;30:1267-1275. 24. Roth M, Epstein DL: Exfoliation syndrome . Am J Ophthalmol 1980;89:477-481. 25. Aasved H: Relationship of intraocular pressure and fibrillopathia epitheliocapsularis . Trans Ophthalmol Soc UK 1979;99:310-311. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Ophthalmology American Medical Association

Pseudoexfoliation, Intraocular Pressure, and Senile Lens Changes in a Population-Based Survey

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Publisher
American Medical Association
Copyright
Copyright © 1982 American Medical Association. All Rights Reserved.
ISSN
0003-9950
eISSN
1538-3687
DOI
10.1001/archopht.1982.01030040058007
Publisher site
See Article on Publisher Site

Abstract

Abstract • The prevalence rate of pseudoexfoliation among persons in the Framingham Eye Study, a population-based survey, increased from 0.6% for ages 52 to 64 years to 2.6% for ages 65 to 74 years to 5.0% for ages 75 to 85 years. Age-adjusted rates showed a statistically significant 2.3 to 1.0 female to male ratio. Pseudoexfoliation was associated with higher intraocular pressure levels and more frequent senile lens changes, but the latter relationship was not statistically significant. The age-specific prevalence rates for the Framingham population are similar to those reported from a mass screening of subjects in Norway, where the condition is thought to be especially common. Some of the previously reported geographic variations in prevalence rates may be due to differences in disease definitions, subject selection, and examination conditions. References 1. Duke-Elder S: Diseases of the Lens and Vitreous: Glaucoma and Hypotony , vol 11, in System of Ophthalmology . St Louis, CV Mosby Co, 1969, p 47. 2. Krause U, Helve J, Forsius H: Pseudoexfoliation of the lens capsule and liberation of iris pigment . Acta Ophthalmol 1973;51:39-46.Crossref 3. Petersen HP: Exfoliation of the interior lens capsule without glaucoma . Acta Ophthalmol 1958;36:375-380.Crossref 4. Aasved H: The geographical distribution of fibrillopathia epitheliocapsularis . Acta Ophthalmol 1969;47:792-810.Crossref 5. Taylor HR, Hollows FC, Moran D: Pseudoexfoliation of the lens in Australian aborigines . Br J Ophthalmol 1977;61:473-475.Crossref 6. Forsius H, Eriksson A: Ophthalmological studies of a population group in the Aland Islands . Acta Ophthalmol 1961;39:318-321. 7. Olivius E, Thorburn W: Prognosis of glaucoma simplex and glaucoma capsulare: A comparative study . Acta Ophthalmol 1978;56:921-934.Crossref 8. Aasved H: The frequency of optic nerve damage and surgical treatment in chronic simplex glaucoma and capsular glaucoma . Acta Ophthalmol 1971;49:589-600.Crossref 9. Layden WE, Shaffer RN: Exfoliation syndrome . Trans Am Ophthalmol Soc 1973;71:128-151. 10. Tarkkanen A: Treatment of chronic openangle glaucoma associated with pseudoexfoliation . Acta Ophthalmol 1965;43:514-523.Crossref 11. Taylor HR: Pseudoexfoliation, an environmental disease? Trans Ophthalmol Soc UK 1979;99:302-307. 12. Leibowitz HM, Krueger DE, Maunder LR, et al: The Framingham Eye Study Monograph . Surv Ophthalmol 1980;24( (suppl) ):343-400.Crossref 13. Kahn HA, Leiboweitz HM, Ganley JP, et al: The Framingham Eye Study: I. Outline and major prevalence findings . Am J Epidemiol 1977;106:17-32. 14. Gart JJ: The comparison of proportions: A review of significance tests, confidence intervals and adjustments for stratification . Rev Intern Stat Inst 1971;39:149-169.Crossref 15. Thomas DG: Exact and asymptotic methods for the combination of 2 × 2 tables . Comput Biomed Res 1975;8:423-446.Crossref 16. Mausner JS, Bahn AK: Epidemiology: An Introductory Test . Philadelphia, WB Saunders Co, 1974, pp 316-321. 17. Armitage P: Statistical Methods in Medical Research . New York, John Wiley & Sons Inc, 1971, pp 387-388. 18. Aasved H: Mass screening for fibrillopathia epitheliocapsularis, so-called senile exfoliation or pseudoexfoliation of the anterior lens capsule . Acta Ophthalmol 1971;49:334-343.Crossref 19. Gradle HS, Sugar HS: Glaucoma capsulare . Am J Ophthalmol 1947;30:12-19. 20. Irvine R: Exfoliation of the lens capsule (glaucoma capsularis) . Arch Ophthalmol 1940;23:138-160.Crossref 21. Vogt A: Ein neues Spaltlampenbild des Prysillengebietes: Hellblaner Pupillensaumfilz mit Hautchenbildung auf der Linsennorderkapsil . Klin Monatsbl Augenheilkd 1925;75:1-12. 22. Horven E: Exfoliation of the superficial layer of the lens capsule (Vogt) and its relation to glaucoma simplex . Br J Ophthalmol 1937;21:625-637.Crossref 23. Holst JC: A statistical study of glaucoma . Am J Ophthalmol 1947;30:1267-1275. 24. Roth M, Epstein DL: Exfoliation syndrome . Am J Ophthalmol 1980;89:477-481. 25. Aasved H: Relationship of intraocular pressure and fibrillopathia epitheliocapsularis . Trans Ophthalmol Soc UK 1979;99:310-311.

Journal

Archives of OphthalmologyAmerican Medical Association

Published: Jul 1, 1982

References