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Proton Pump Inhibitor Use, Hip Fracture, and Change in Bone Mineral Density in Postmenopausal Women

Proton Pump Inhibitor Use, Hip Fracture, and Change in Bone Mineral Density in Postmenopausal Women ORIGINAL INVESTIGATION LESS IS MORE Proton Pump Inhibitor Use, Hip Fracture, and Change in Bone Mineral Density in Postmenopausal Women Results From the Women’s Health Initiative Shelly L. Gray, PharmD, MS; Andrea Z. LaCroix, PhD; Joseph Larson, MS; John Robbins, MD; Jane A. Cauley, DrPH; JoAnn E. Manson, MD, DrPH; Zhao Chen, PhD Background: Proton pump inhibitor (PPI) medica- Results: During 1 005 126 person-years of follow-up, tions have been inconsistently shown to be associated with 1500 hip fractures, 4881 forearm or wrist fractures, 2315 osteoporotic fractures. We examined the association of clinical spine fractures, and 21 247 total fractures oc- PPI use with bone outcomes (fracture, bone mineral den- curred. The multivariate-adjusted hazard ratios for cur- sity [BMD]). rent PPI use were 1.00 (95% confidence interval [CI], 0.71-1.40) for hip fracture, 1.47 (95% CI, 1.18-1.82) for Methods: This prospective analysis included 161 806 clinical spine fracture, 1.26 (95% CI, 1.05-1.51) for fore- postmenopausal women 50 to 79 years old, without his- arm or wrist fracture, and 1.25 (95% CI, 1.15-1.36) for tory of hip fracture, enrolled in the Women’s Health Ini- total fractures. The BMD measurements did not vary be- tiative (WHI) Observational Study and Clinical Trials with http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA Internal Medicine American Medical Association

Proton Pump Inhibitor Use, Hip Fracture, and Change in Bone Mineral Density in Postmenopausal Women

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Publisher
American Medical Association
Copyright
Copyright 2010 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
2168-6106
eISSN
2168-6114
DOI
10.1001/archinternmed.2010.94
pmid
20458083
Publisher site
See Article on Publisher Site

Abstract

ORIGINAL INVESTIGATION LESS IS MORE Proton Pump Inhibitor Use, Hip Fracture, and Change in Bone Mineral Density in Postmenopausal Women Results From the Women’s Health Initiative Shelly L. Gray, PharmD, MS; Andrea Z. LaCroix, PhD; Joseph Larson, MS; John Robbins, MD; Jane A. Cauley, DrPH; JoAnn E. Manson, MD, DrPH; Zhao Chen, PhD Background: Proton pump inhibitor (PPI) medica- Results: During 1 005 126 person-years of follow-up, tions have been inconsistently shown to be associated with 1500 hip fractures, 4881 forearm or wrist fractures, 2315 osteoporotic fractures. We examined the association of clinical spine fractures, and 21 247 total fractures oc- PPI use with bone outcomes (fracture, bone mineral den- curred. The multivariate-adjusted hazard ratios for cur- sity [BMD]). rent PPI use were 1.00 (95% confidence interval [CI], 0.71-1.40) for hip fracture, 1.47 (95% CI, 1.18-1.82) for Methods: This prospective analysis included 161 806 clinical spine fracture, 1.26 (95% CI, 1.05-1.51) for fore- postmenopausal women 50 to 79 years old, without his- arm or wrist fracture, and 1.25 (95% CI, 1.15-1.36) for tory of hip fracture, enrolled in the Women’s Health Ini- total fractures. The BMD measurements did not vary be- tiative (WHI) Observational Study and Clinical Trials with

Journal

JAMA Internal MedicineAmerican Medical Association

Published: May 10, 2010

References