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PROTAMINE AND ALLERGY

PROTAMINE AND ALLERGY The injection of protamine zinc insulin for the treatment of diabetes is followed in some patients by redness and swelling at the site of injection, sufficiently severe at times to lead them to discontinue the use of protamine zinc insulin. It therefore seemed desirable to investigate the nature of these reactions, especially from the standpoint of a possibly allergic mechanism. We here record our observations as to the causes and report a new observation, the induced sensitization to insulin which occasionally appears to follow the use of protamine zinc insulin. SENSITIVITY STUDIES The first part of this paper deals with the results of intracutaneous tests with protamine. The test material used was a solution of protamine in Coca's solution in a concentration containing 0.1 mg. of nitrogen per cubic centimeter. The tests were performed by the intracutaneous injection of 0.02 cc. of the test solution on the flexor surface of http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA American Medical Association

PROTAMINE AND ALLERGY

JAMA , Volume 113 (3) – Jul 15, 1939

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References (3)

Publisher
American Medical Association
Copyright
Copyright © 1939 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
0098-7484
eISSN
1538-3598
DOI
10.1001/jama.1939.02800280010003
Publisher site
See Article on Publisher Site

Abstract

The injection of protamine zinc insulin for the treatment of diabetes is followed in some patients by redness and swelling at the site of injection, sufficiently severe at times to lead them to discontinue the use of protamine zinc insulin. It therefore seemed desirable to investigate the nature of these reactions, especially from the standpoint of a possibly allergic mechanism. We here record our observations as to the causes and report a new observation, the induced sensitization to insulin which occasionally appears to follow the use of protamine zinc insulin. SENSITIVITY STUDIES The first part of this paper deals with the results of intracutaneous tests with protamine. The test material used was a solution of protamine in Coca's solution in a concentration containing 0.1 mg. of nitrogen per cubic centimeter. The tests were performed by the intracutaneous injection of 0.02 cc. of the test solution on the flexor surface of

Journal

JAMAAmerican Medical Association

Published: Jul 15, 1939

There are no references for this article.