Abstract • Five commonly used prostheses were compared for susceptibility to bacteremic infection: US Catheter and Instrument Co (USCI) Ultralight weight knitted Dacron, USCI Sauvage filamentous velour Dacron, Meadox Microvel double velour knitted Dacron, polytetrafluoroethylene (PTFE)-lmpra, and PTFE-Goretex. We used 6-mm diameter grafts to replace 4-cm segments of the abdominal aorta in 150 mongrel dogs. Fifteen dogs were used for each graft type and each healing interval: three and six months posttransplantation. At the appropriate time after implantation, an intravenous infusion of 108 organisms of Staphylococcus aureus was administered to the ten experimental dogs in each graft type; five dogs of each graft type served as sterile controls. Three weeks later, the grafts were aseptically removed, inspected for the completeness of neointimal healing, and cultured for bacteria. At three months, the Sauvage graft achieved the lowest infection rate (10%) with the highest incidence of complete neointimal lining (71%). In the six-month series, there were no statistical differences between the knitted Dacron prostheses, but all Dacron grafts were superior to the PTFE grafts with regard to susceptibility to bacteremic infection and completeness of intimal lining. (Arch Surg 115:1379-1383, 1980) References 1. Moore WS, Rosson CT, Hall AD, Thomas AN: Transient bacteremia: A cause of infection in prosthetic vascular grafts . Am J Surg 117:342-343, 1969.Crossref 2. Goldstone J, Moore WS: Infection in vascular prosthesis: Clinical manifestations and surgical management . Am J Surg 128:225-233, 1974.Crossref 3. Moore WS, Swanson RJ, Campagna G, Bean B: Pseudointimal development and vascular prosthesis susceptibility to bacteremic infection . Surg Forum 25:250-252, 1974. 4. Malone JM, Moore WS, Campagna G, Bean B: Bacteremic infectibility of vascular grafts: The influence of pseudointimal integrity and duration of graft function . Surgery 78:211-216, 1975. 5. Roon AJ, Malone JM, Moore WS, et al: Bacteremic infectibility: A function of vascular graft material and design . J Surg Res 22:489-498, 1977.Crossref 6. Bunham JS, Flanigan P, Goodreau JJ, et al: Nonvein bypass in below-knee reoperation for lower-limb ischemia . Surgery 84:417-424, 1978. 7. Haimov H, Giron F, Jacobson JH II: The expanded polytetrafluoroethylene graft: Three years' experience with 362 grafts . Arch Surg 114:673-677, 1979.Crossref 8. Moore WS, Rosson CT, Hall AD: Effect of prophylactic antibiotics in preventing bacteremic infection of vascular prostheses . Surgery 69:825-828, 1971. 9. Moore WS, Malone JM: The use of prophylactic antibiotics in vascular surgery . J Surg Pract 6:24-36, 1978.
Archives of Surgery – American Medical Association
Published: Nov 1, 1980