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Prostate Cancer–Specific Survival Following Salvage Radiotherapy vs Observation in Men With Biochemical Recurrence After Radical Prostatectomy

Prostate Cancer–Specific Survival Following Salvage Radiotherapy vs Observation in Men With... PRELIMINARY COMMUNICATION Prostate Cancer–Specific Survival Following Salvage Radiotherapy vs Observation in Men With Biochemical Recurrence After Radical Prostatectomy Bruce J. Trock, PhD Context Biochemical disease recurrence after radical prostatectomy often prompts Misop Han, MD salvage radiotherapy, but no studies to date have had sufficient numbers of patients or follow-up to determine whether radiotherapy improves survival, and if so, the sub- Stephen J. Freedland, MD group of men most likely to benefit. Elizabeth B. Humphreys, MS Objectives To quantify the relative improvement in prostate cancer–specific sur- Theodore L. DeWeese, MD vival of salvage radiotherapy vs no therapy after biochemical recurrence following pros- tatectomy, and to identify subgroups for whom salvage treatment is most beneficial. Alan W. Partin, MD, PhD Design, Setting, and Patients Retrospective analysis of a cohort of 635 US men Patrick C. Walsh, MD undergoing prostatectomy from 1982-2004, followed up through December 28, 2007, EARLY 60 000 MEN (27% OF who experienced biochemical and/or local recurrence and received no salvage treat- newly diagnosed cases) will ment (n = 397), salvage radiotherapy alone (n = 160), or salvage radiotherapy com- bined with hormonal therapy (n = 78). have undergone radical pros- Ntatectomy in 2007. Although Main Outcome Measure Prostate http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA American Medical Association

Prostate Cancer–Specific Survival Following Salvage Radiotherapy vs Observation in Men With Biochemical Recurrence After Radical Prostatectomy

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Publisher
American Medical Association
Copyright
Copyright 2008 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
0098-7484
eISSN
1538-3598
DOI
10.1001/jama.299.23.2760
pmid
18560003
Publisher site
See Article on Publisher Site

Abstract

PRELIMINARY COMMUNICATION Prostate Cancer–Specific Survival Following Salvage Radiotherapy vs Observation in Men With Biochemical Recurrence After Radical Prostatectomy Bruce J. Trock, PhD Context Biochemical disease recurrence after radical prostatectomy often prompts Misop Han, MD salvage radiotherapy, but no studies to date have had sufficient numbers of patients or follow-up to determine whether radiotherapy improves survival, and if so, the sub- Stephen J. Freedland, MD group of men most likely to benefit. Elizabeth B. Humphreys, MS Objectives To quantify the relative improvement in prostate cancer–specific sur- Theodore L. DeWeese, MD vival of salvage radiotherapy vs no therapy after biochemical recurrence following pros- tatectomy, and to identify subgroups for whom salvage treatment is most beneficial. Alan W. Partin, MD, PhD Design, Setting, and Patients Retrospective analysis of a cohort of 635 US men Patrick C. Walsh, MD undergoing prostatectomy from 1982-2004, followed up through December 28, 2007, EARLY 60 000 MEN (27% OF who experienced biochemical and/or local recurrence and received no salvage treat- newly diagnosed cases) will ment (n = 397), salvage radiotherapy alone (n = 160), or salvage radiotherapy com- bined with hormonal therapy (n = 78). have undergone radical pros- Ntatectomy in 2007. Although Main Outcome Measure Prostate

Journal

JAMAAmerican Medical Association

Published: Jun 18, 2008

References