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Propylthiouracil in Hemorrhagic Pancreatitis

Propylthiouracil in Hemorrhagic Pancreatitis Abstract Since the classic theory of Opie5 postulating the reflux of bile into the pancreatic duct by virtue of a common channel, various therapeutic agents have been evaluated in both clinical trials and experimental animals. Recent studies7-10 have demonstrated that death in canine experimental hemorrhagic pancreatitis induced by injection of bile into pancreatic ducts can largely be prevented by use of certain antibiotics. Thus, a prerequisite in the evaluation of beneficial effects of therapeutic agents in lowering the mortality rates in acute canine pancreatitis is the recognition and prevention of the susceptibility of dogs, under adverse conditions, to fulminating infections. Hara and associates3 have described a method of producing a sterile yet highly lethal form of acute hemorrhagic pancreatitis in dogs. In 1954, Starr,11 in reviewing the modern approach to treatment of pancreatitis, recommended the use of 3-5 gm. of propylthiouracil. No comments were made on its References 1. Enquist, I. F.; Rosen, R.; Aiello, R. G., and Ikezono, E.: Effect of Hypothermia on Experimental Pancreatitis , Arch. Surg. 82:281-284, 1961.Crossref 2. Fine, J., et al.: Bacterial Factor in Traumatic Shock , Ann. N.Y. Acad. Sci. 55:429 ( (Sept.) ) 1952.Crossref 3. Hara, M.; Baber, J. C.; Millar, P. H., and Hardin, H.: Experimental Hemorrhagic Pancreatitis , Surg. Forum 5:395-400, 1954. 4. Lewis, F. J., and Wangensteen, O. H.: Antibiotics in the Treatment of Experimental Acute Hemorrhagic Pancreatitis in Dogs , Proc. Soc. Exper. Biol. Med. 74:453-455, 1950.Crossref 5. Opie, E. L.: Bull. Johns Hopkins Hosp. 12: 483, 1901. 6. Paulette, R. E.; Challis, T. W.; Reid, L. C., and Hinton, J. W.: The Effect of Propyl-Thiouracil in Dogs , Surg. Forum 8:258-261, 1957. 7. Persky, L.; Swinburg, F.; Jacob, S., and Fine, J.: Aureomycin in Experimental Acute Pancreatitis of Dogs , Surgery 30:652-656, 1951. 8. Reid, C., and Kossa, J.: The Action of Antithyroid Agents and Thyroxine on Tissue Homogenates , Arch. Biochem. 53:321-326, 1954.Crossref 9. Reid, L. C.; Challis, T. W.; Paulette, R. E., and Hinton, J. W.: The Role of Propylthiouracil in Pancreatitis , Surg. Forum 7:445-448, 1956. 10. Schwineburg, F.; Jacob, S.; Persky, L., and Fine, J.: Further Studies on the Role of Bacteria in Death from Acute Hemorrhagic Pancreatitis in Dogs , Surgery 33:367-369, 1953. 11. Starr, K. W.: The Modern Approach to Pancreatitis , Western J. Surg. 63:501-502 ( (Aug.) ) 1955. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Surgery American Medical Association

Propylthiouracil in Hemorrhagic Pancreatitis

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Publisher
American Medical Association
Copyright
Copyright © 1963 American Medical Association. All Rights Reserved.
ISSN
0004-0010
eISSN
1538-3644
DOI
10.1001/archsurg.1963.01310080067015
Publisher site
See Article on Publisher Site

Abstract

Abstract Since the classic theory of Opie5 postulating the reflux of bile into the pancreatic duct by virtue of a common channel, various therapeutic agents have been evaluated in both clinical trials and experimental animals. Recent studies7-10 have demonstrated that death in canine experimental hemorrhagic pancreatitis induced by injection of bile into pancreatic ducts can largely be prevented by use of certain antibiotics. Thus, a prerequisite in the evaluation of beneficial effects of therapeutic agents in lowering the mortality rates in acute canine pancreatitis is the recognition and prevention of the susceptibility of dogs, under adverse conditions, to fulminating infections. Hara and associates3 have described a method of producing a sterile yet highly lethal form of acute hemorrhagic pancreatitis in dogs. In 1954, Starr,11 in reviewing the modern approach to treatment of pancreatitis, recommended the use of 3-5 gm. of propylthiouracil. No comments were made on its References 1. Enquist, I. F.; Rosen, R.; Aiello, R. G., and Ikezono, E.: Effect of Hypothermia on Experimental Pancreatitis , Arch. Surg. 82:281-284, 1961.Crossref 2. Fine, J., et al.: Bacterial Factor in Traumatic Shock , Ann. N.Y. Acad. Sci. 55:429 ( (Sept.) ) 1952.Crossref 3. Hara, M.; Baber, J. C.; Millar, P. H., and Hardin, H.: Experimental Hemorrhagic Pancreatitis , Surg. Forum 5:395-400, 1954. 4. Lewis, F. J., and Wangensteen, O. H.: Antibiotics in the Treatment of Experimental Acute Hemorrhagic Pancreatitis in Dogs , Proc. Soc. Exper. Biol. Med. 74:453-455, 1950.Crossref 5. Opie, E. L.: Bull. Johns Hopkins Hosp. 12: 483, 1901. 6. Paulette, R. E.; Challis, T. W.; Reid, L. C., and Hinton, J. W.: The Effect of Propyl-Thiouracil in Dogs , Surg. Forum 8:258-261, 1957. 7. Persky, L.; Swinburg, F.; Jacob, S., and Fine, J.: Aureomycin in Experimental Acute Pancreatitis of Dogs , Surgery 30:652-656, 1951. 8. Reid, C., and Kossa, J.: The Action of Antithyroid Agents and Thyroxine on Tissue Homogenates , Arch. Biochem. 53:321-326, 1954.Crossref 9. Reid, L. C.; Challis, T. W.; Paulette, R. E., and Hinton, J. W.: The Role of Propylthiouracil in Pancreatitis , Surg. Forum 7:445-448, 1956. 10. Schwineburg, F.; Jacob, S.; Persky, L., and Fine, J.: Further Studies on the Role of Bacteria in Death from Acute Hemorrhagic Pancreatitis in Dogs , Surgery 33:367-369, 1953. 11. Starr, K. W.: The Modern Approach to Pancreatitis , Western J. Surg. 63:501-502 ( (Aug.) ) 1955.

Journal

Archives of SurgeryAmerican Medical Association

Published: Feb 1, 1963

References

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