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Propranolol as Treatment for Thyrotoxicosis

Propranolol as Treatment for Thyrotoxicosis Abstract To the Editor.— I read with interest the article by Dr Mazzaferri and associates in the Archives1 concerning the treatment of patients with thyrotoxicosis with propranolol alone. Although the authors excluded from their series individuals with "severe disease" because this was not "ethically justifiable," they withheld specific treatment from eight patients for eight months for the sake of their study.I question the justification of conducting this study on the basis of data already available in the literature on the lack of specific effect of propranolol in the treatment of thyrotoxicosis. The authors themselves quote the investigation of McLarty and colleagues,2 who, after a trial similar to theirs, concluded that propranolol has no direct in vivo effect on thyroid function and is not an acceptable alternative to conventional antithyroid drugs, even in milder cases of thyrotoxicosis. In 1969, Hadden and co-workers3 demonstrated in 18 patients with thyrotoxicosis References 1. Mazzaferri EL, Reynolds JC, Young RL, et al: Propranolol as primary therapy for thyrotoxicosis . Arch Intern Med 136:50-56, 1976.Crossref 2. McLarty DG, Brownlie BEW, Alexander WD, et al: Remission of thyrotoxicosis during treatment with propranolol . Br Med J 2:332-334, 1973.Crossref 3. Hadden DR, Bell TK, McDevitt DG, et al: Propranolol and the utilization of radioiodine by the human thyroid gland . Acta Endocrinol 61:393-396, 1969. 4. Biran S, Tal E: Effect of beat-blocking drug propranolol on 131I utilization in euthyroid patients . J Clin Pharmacol 12:105-107, 1972. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Internal Medicine American Medical Association

Propranolol as Treatment for Thyrotoxicosis

Archives of Internal Medicine , Volume 136 (10) – Oct 1, 1976

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Publisher
American Medical Association
Copyright
Copyright © 1976 American Medical Association. All Rights Reserved.
ISSN
0003-9926
eISSN
1538-3679
DOI
10.1001/archinte.1976.03630100105032
Publisher site
See Article on Publisher Site

Abstract

Abstract To the Editor.— I read with interest the article by Dr Mazzaferri and associates in the Archives1 concerning the treatment of patients with thyrotoxicosis with propranolol alone. Although the authors excluded from their series individuals with "severe disease" because this was not "ethically justifiable," they withheld specific treatment from eight patients for eight months for the sake of their study.I question the justification of conducting this study on the basis of data already available in the literature on the lack of specific effect of propranolol in the treatment of thyrotoxicosis. The authors themselves quote the investigation of McLarty and colleagues,2 who, after a trial similar to theirs, concluded that propranolol has no direct in vivo effect on thyroid function and is not an acceptable alternative to conventional antithyroid drugs, even in milder cases of thyrotoxicosis. In 1969, Hadden and co-workers3 demonstrated in 18 patients with thyrotoxicosis References 1. Mazzaferri EL, Reynolds JC, Young RL, et al: Propranolol as primary therapy for thyrotoxicosis . Arch Intern Med 136:50-56, 1976.Crossref 2. McLarty DG, Brownlie BEW, Alexander WD, et al: Remission of thyrotoxicosis during treatment with propranolol . Br Med J 2:332-334, 1973.Crossref 3. Hadden DR, Bell TK, McDevitt DG, et al: Propranolol and the utilization of radioiodine by the human thyroid gland . Acta Endocrinol 61:393-396, 1969. 4. Biran S, Tal E: Effect of beat-blocking drug propranolol on 131I utilization in euthyroid patients . J Clin Pharmacol 12:105-107, 1972.

Journal

Archives of Internal MedicineAmerican Medical Association

Published: Oct 1, 1976

References