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PROLONGED USE OF ARTERENOL FOR SHOCK FOLLOWING MYOCARDIAL INFARCTION WITH PATIENT SURVIVAL

PROLONGED USE OF ARTERENOL FOR SHOCK FOLLOWING MYOCARDIAL INFARCTION WITH PATIENT SURVIVAL Abstract SURVEY the literature, to the best of my knowledge, has not revealed any case of shock following myocardial infarction treated with continuous levarterenol (Levophed) drip for over eight days with patient survival.* It is estimated that the mortality rate is between 80% and 90% 7 in sustained hypotension following myocardial infarction. The delayed gradual onset of shock has been described8 as the clinical manifestation of progressive failure of the infarcted left ventricle and as almost invariably fatal. This is in contradistinction to the hypotension that may follow immediately after the onset of the infarct, in which case about 50% of the patients recover spontaneously within one hour. A 52-year-old well-nourished white women developed recurrent episodes of substernal pain of 24 hours' duration. Her husband had died of a brain tumor the preceding day. When first seen at home, she was lying in bed having recurrent attacks of anginal pain References 1. References 1-6. 2. Sampson, J. J., and Zipser, A.: Norepinephrine in Shock Following Myocardial Infarction , Circulation 9:38, 1954.Crossref 3. Gazes, P. C.; Goldberg, L. I., and Darby, T. D.: Heart Force Effects of Sympathomimetic Amines as a Basis for Their Use in Shock Accompanying Myocardial Infarction , Circulation 8: 883, 1953.Crossref 4. Miller, A. J.; Shifrin, A.; Kaplan, B. M.; Gold, H.; Billings, A., and Katz, L. N.; Arterenol in Treatment of Shock , J. A. M. A. 152:1198, 1953.Crossref 5. Miller, A. J., and Baker, L. A.: 1-Arterenol (Levophed) in Treatment of Shock Due to Myocardial Infarction , A. M. A. Arch. Int. Med. 89: 591, 1952.Crossref 6. Griffith, G. C.; Wallace, W. B.; Cochran, B., Jr.; Nerlich, W. E., and Frasher, W. G.: The Treatment of Shock Associated with Myocardial Infarction , Circulation 9:527, 1954.Crossref 7. Kurland, G. S., and Malach, M.: The Clinical Use of Nor-Epinephrine in the Treatment of Shock Accompanying Myocardial Infarction and Other Conditions , New England J. Med. 247:383, 1952.Crossref 8. Hellerstein, H. K.; Brofman, B. L., and Caskey, W. H.: Shock Accompanying Myocardial Infarction: Treatment with Pressor Amines , Am. Heart J. 44:407, 1952.Crossref 9. Selzer, A.: The Hypotensive State Following Acute Myocardial Infarction: Clinical Observations , Am. Heart J. 44:1, 1952.Crossref 10. Kurland, G. S., and Freedberg, A. S.: Potentiating Effect of ACTH and of Cortisone on Pressor Response to Intravenous Infusion of L-Nor-Epinephrine , Proc. Soc. Exper. Biol. & Med. 78:28, 1951. 11. Fritz, I., and Levine, R.: Action of Adrenal Cortical Steroids and Nor-Epinephrine on Vascular Responses of Adrenalectomized Rats, Abstracted , Am. J. Physiol. 163:713, 1950. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png A.M.A. Archives of Internal Medicine American Medical Association

PROLONGED USE OF ARTERENOL FOR SHOCK FOLLOWING MYOCARDIAL INFARCTION WITH PATIENT SURVIVAL

A.M.A. Archives of Internal Medicine , Volume 98 (3) – Sep 1, 1956

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Publisher
American Medical Association
Copyright
Copyright © 1956 American Medical Association. All Rights Reserved.
ISSN
0888-2479
DOI
10.1001/archinte.1956.00250270116016
Publisher site
See Article on Publisher Site

Abstract

Abstract SURVEY the literature, to the best of my knowledge, has not revealed any case of shock following myocardial infarction treated with continuous levarterenol (Levophed) drip for over eight days with patient survival.* It is estimated that the mortality rate is between 80% and 90% 7 in sustained hypotension following myocardial infarction. The delayed gradual onset of shock has been described8 as the clinical manifestation of progressive failure of the infarcted left ventricle and as almost invariably fatal. This is in contradistinction to the hypotension that may follow immediately after the onset of the infarct, in which case about 50% of the patients recover spontaneously within one hour. A 52-year-old well-nourished white women developed recurrent episodes of substernal pain of 24 hours' duration. Her husband had died of a brain tumor the preceding day. When first seen at home, she was lying in bed having recurrent attacks of anginal pain References 1. References 1-6. 2. Sampson, J. J., and Zipser, A.: Norepinephrine in Shock Following Myocardial Infarction , Circulation 9:38, 1954.Crossref 3. Gazes, P. C.; Goldberg, L. I., and Darby, T. D.: Heart Force Effects of Sympathomimetic Amines as a Basis for Their Use in Shock Accompanying Myocardial Infarction , Circulation 8: 883, 1953.Crossref 4. Miller, A. J.; Shifrin, A.; Kaplan, B. M.; Gold, H.; Billings, A., and Katz, L. N.; Arterenol in Treatment of Shock , J. A. M. A. 152:1198, 1953.Crossref 5. Miller, A. J., and Baker, L. A.: 1-Arterenol (Levophed) in Treatment of Shock Due to Myocardial Infarction , A. M. A. Arch. Int. Med. 89: 591, 1952.Crossref 6. Griffith, G. C.; Wallace, W. B.; Cochran, B., Jr.; Nerlich, W. E., and Frasher, W. G.: The Treatment of Shock Associated with Myocardial Infarction , Circulation 9:527, 1954.Crossref 7. Kurland, G. S., and Malach, M.: The Clinical Use of Nor-Epinephrine in the Treatment of Shock Accompanying Myocardial Infarction and Other Conditions , New England J. Med. 247:383, 1952.Crossref 8. Hellerstein, H. K.; Brofman, B. L., and Caskey, W. H.: Shock Accompanying Myocardial Infarction: Treatment with Pressor Amines , Am. Heart J. 44:407, 1952.Crossref 9. Selzer, A.: The Hypotensive State Following Acute Myocardial Infarction: Clinical Observations , Am. Heart J. 44:1, 1952.Crossref 10. Kurland, G. S., and Freedberg, A. S.: Potentiating Effect of ACTH and of Cortisone on Pressor Response to Intravenous Infusion of L-Nor-Epinephrine , Proc. Soc. Exper. Biol. & Med. 78:28, 1951. 11. Fritz, I., and Levine, R.: Action of Adrenal Cortical Steroids and Nor-Epinephrine on Vascular Responses of Adrenalectomized Rats, Abstracted , Am. J. Physiol. 163:713, 1950.

Journal

A.M.A. Archives of Internal MedicineAmerican Medical Association

Published: Sep 1, 1956

References