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Prolonged Pharmacologic Activity of Neuroleptic Drugs

Prolonged Pharmacologic Activity of Neuroleptic Drugs Abstract To the Editor.— Campbell and Baldessarini1 described an experiment in which they administered moderatesingle doses of haloperidol to rats and found that the behavioral response to the dopamine agonist apomorphine was reduced significantly for at least one month. They commented that the plasma elimination half-life values of neuroleptic drugs are usually reported in the range of 20 to 40 hours, whereas the apparent half-life for recovery of normal response to apomorphine was 12.8 days. Moreover, Sedval and colleagues2 also showed a lack of concordance between dopamine D2 receptor occupancy in the brains of schizophrenics and plasma haloperidol levels following the withdrawal of the drug. Subjects and Methods.— Recently, we measured levels of haloperidol and reduced haloperidol in the plasma of healthy volunteers after single oral doses of 5 mg of haloperidol. It is standard practice in single-dose pharmacokinetic studies to follow plasma levels for three to References 1. Campbell A, Baldessarini RJ: Prolonged pharmacologic activity of neuroleptics . Arch Gen Psychiatry 1985;42:637.Crossref 2. Sedval G, Farde L, Wiesel FA, Ehrin E: Dopamine-D2 receptor occupancy in the brain of schizophrenics during and after antipsychotic drug treatment. Read before the Annual Meeting of the American College of Neuropsychopharmacology, Maui, Hawaii, Dec 13, 1985. 3. Forsman A, Ohman R: Pharmacokinetic studies on haloperidol in men . Curr Ther Res 1976;20:319-336. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of General Psychiatry American Medical Association

Prolonged Pharmacologic Activity of Neuroleptic Drugs

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Publisher
American Medical Association
Copyright
Copyright © 1987 American Medical Association. All Rights Reserved.
ISSN
0003-990X
eISSN
1598-3636
DOI
10.1001/archpsyc.1987.01800130111024
Publisher site
See Article on Publisher Site

Abstract

Abstract To the Editor.— Campbell and Baldessarini1 described an experiment in which they administered moderatesingle doses of haloperidol to rats and found that the behavioral response to the dopamine agonist apomorphine was reduced significantly for at least one month. They commented that the plasma elimination half-life values of neuroleptic drugs are usually reported in the range of 20 to 40 hours, whereas the apparent half-life for recovery of normal response to apomorphine was 12.8 days. Moreover, Sedval and colleagues2 also showed a lack of concordance between dopamine D2 receptor occupancy in the brains of schizophrenics and plasma haloperidol levels following the withdrawal of the drug. Subjects and Methods.— Recently, we measured levels of haloperidol and reduced haloperidol in the plasma of healthy volunteers after single oral doses of 5 mg of haloperidol. It is standard practice in single-dose pharmacokinetic studies to follow plasma levels for three to References 1. Campbell A, Baldessarini RJ: Prolonged pharmacologic activity of neuroleptics . Arch Gen Psychiatry 1985;42:637.Crossref 2. Sedval G, Farde L, Wiesel FA, Ehrin E: Dopamine-D2 receptor occupancy in the brain of schizophrenics during and after antipsychotic drug treatment. Read before the Annual Meeting of the American College of Neuropsychopharmacology, Maui, Hawaii, Dec 13, 1985. 3. Forsman A, Ohman R: Pharmacokinetic studies on haloperidol in men . Curr Ther Res 1976;20:319-336.

Journal

Archives of General PsychiatryAmerican Medical Association

Published: Jan 1, 1987

References