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Prolonged Administration of Triamcinolone in Dermatologic Disorders: Therapeutic Efficacy and Side-Effects

Prolonged Administration of Triamcinolone in Dermatologic Disorders: Therapeutic Efficacy and... Abstract Triamcinolone (Aristocort*) is a potent corticosteroid. Its effectiveness as a morbidostatic anti-inflammatory, anti-allergic, and antirheumatic agent has been reported by many investigators.1-8 Side-effects also result from the use of triamcinolone. It is the purpose of this report to record the therapeutic efficacy and the incidence and severity of side-effects with prolonged administration of triamcinolone to patients with various inflammatory, allergic, and pruritic dermatoses. Background There has been an intensive search for corticosteroid analogues with greater antiinflammatory activity and less serious side-effects than cortisone and hydrocortisone. Some of these new corticosteroids have an enhanced anti-inflammatory activity and less water and salt retention (prednisone and prednisolone). However, when a fluorine particle was added to hydrocortisone and prednisolone in the 9-α position, increased anti-inflammatory properties were marred by increased salt and water retention. Bernstein et al.,9 studying one of the last mentioned compounds, found References 1. The Aristocort used in this study was supplied by Lederle Laboratories Division, American Cyanamid Company, Pearl River, N. Y. 2. Hellman, L.; Zumoff, B.; Schwartz, M. K.; Gallagher, T. F.; Berntsen, C. A., and Freyberg, R. H.: Antirheumatic and Metabolic Effects of a New Synthetic Steroid , Ann. Rheumat. Dis. 16:141, 1957. 3. Sherwood, H., and Cooke, R. A.: Preliminary Evaluation of a New Corticosteroid in Allergic Diseases , J. Allergy 28:97, 1957.Crossref 4. Black, R. L.; Yielding, K. L., and Bunim, J. J.: Observations on New Synthetic Antirheumatic Steroids and Critical Evaluation of Prednisone Therapy in Rheumatoid Arthritis , J. Chron. Dis. 5:751, 1957.Crossref 5. Hellman, L.; Zumoff, B., Kretchmer, N.; Minsky, A., and Kramer, B.: The Treatment of the Nephrotic Syndrome with Triamcinolone , A. M. A. J. Dis. Child. 94:437, 1957. 6. Rein, C. R.; Fleischmajer, R., and Rosenthal, A. L.: Use of a New Corticosteroid (Aristocort Diacetate) in Dermatology , J. A. M. A. 165:1821, 1957.Crossref 7. Dubois, E. L.: Triamcinolone in the Treatment of Systemic Lupus Erythematosus , Clin. Res. 6:65, 1958. 8. Shelley, W. B.; Harun, J. S., and Pillsbury, D. M.: The Treatment of Psoriasis and Other Dermatoses with Triamcinolone (Aristocort) , J. A. M. A. 167:959, 1958.Crossref 9. Hartung, E. F.: Triamcinolone in Treatment of Rheumatoid Arthritis , J. A. M. A. 167:973, 1958.Crossref 10. Bernstein, S.; Lenhard, R. H.; Allen, W. S.; Heller, M.; Littell, R.; Stolar, S. M.; Feldman, L. I., and Blank, R. H.: 16-Hydroxylated Steroids: IV. The Synthesis of the 16-α Hydroxy Derivatives of 9-α-Halo-Steroids , J. Am. Chem. Soc. 78:5693, 1956.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png A.M.A. Archives of Dermatology American Medical Association

Prolonged Administration of Triamcinolone in Dermatologic Disorders: Therapeutic Efficacy and Side-Effects

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Publisher
American Medical Association
Copyright
Copyright © 1959 American Medical Association. All Rights Reserved.
ISSN
0096-5359
DOI
10.1001/archderm.1959.01560180005002
Publisher site
See Article on Publisher Site

Abstract

Abstract Triamcinolone (Aristocort*) is a potent corticosteroid. Its effectiveness as a morbidostatic anti-inflammatory, anti-allergic, and antirheumatic agent has been reported by many investigators.1-8 Side-effects also result from the use of triamcinolone. It is the purpose of this report to record the therapeutic efficacy and the incidence and severity of side-effects with prolonged administration of triamcinolone to patients with various inflammatory, allergic, and pruritic dermatoses. Background There has been an intensive search for corticosteroid analogues with greater antiinflammatory activity and less serious side-effects than cortisone and hydrocortisone. Some of these new corticosteroids have an enhanced anti-inflammatory activity and less water and salt retention (prednisone and prednisolone). However, when a fluorine particle was added to hydrocortisone and prednisolone in the 9-α position, increased anti-inflammatory properties were marred by increased salt and water retention. Bernstein et al.,9 studying one of the last mentioned compounds, found References 1. The Aristocort used in this study was supplied by Lederle Laboratories Division, American Cyanamid Company, Pearl River, N. Y. 2. Hellman, L.; Zumoff, B.; Schwartz, M. K.; Gallagher, T. F.; Berntsen, C. A., and Freyberg, R. H.: Antirheumatic and Metabolic Effects of a New Synthetic Steroid , Ann. Rheumat. Dis. 16:141, 1957. 3. Sherwood, H., and Cooke, R. A.: Preliminary Evaluation of a New Corticosteroid in Allergic Diseases , J. Allergy 28:97, 1957.Crossref 4. Black, R. L.; Yielding, K. L., and Bunim, J. J.: Observations on New Synthetic Antirheumatic Steroids and Critical Evaluation of Prednisone Therapy in Rheumatoid Arthritis , J. Chron. Dis. 5:751, 1957.Crossref 5. Hellman, L.; Zumoff, B., Kretchmer, N.; Minsky, A., and Kramer, B.: The Treatment of the Nephrotic Syndrome with Triamcinolone , A. M. A. J. Dis. Child. 94:437, 1957. 6. Rein, C. R.; Fleischmajer, R., and Rosenthal, A. L.: Use of a New Corticosteroid (Aristocort Diacetate) in Dermatology , J. A. M. A. 165:1821, 1957.Crossref 7. Dubois, E. L.: Triamcinolone in the Treatment of Systemic Lupus Erythematosus , Clin. Res. 6:65, 1958. 8. Shelley, W. B.; Harun, J. S., and Pillsbury, D. M.: The Treatment of Psoriasis and Other Dermatoses with Triamcinolone (Aristocort) , J. A. M. A. 167:959, 1958.Crossref 9. Hartung, E. F.: Triamcinolone in Treatment of Rheumatoid Arthritis , J. A. M. A. 167:973, 1958.Crossref 10. Bernstein, S.; Lenhard, R. H.; Allen, W. S.; Heller, M.; Littell, R.; Stolar, S. M.; Feldman, L. I., and Blank, R. H.: 16-Hydroxylated Steroids: IV. The Synthesis of the 16-α Hydroxy Derivatives of 9-α-Halo-Steroids , J. Am. Chem. Soc. 78:5693, 1956.Crossref

Journal

A.M.A. Archives of DermatologyAmerican Medical Association

Published: Jun 1, 1959

References

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