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Progressive Lipodystrophy and Lipoatrophic Diabetes: Review of the Literature and Case Reports

Progressive Lipodystrophy and Lipoatrophic Diabetes: Review of the Literature and Case Reports Abstract Progressive lipodystrophy is a relatively rare disease characterized by complete absence of subcutaneous fat in certain areas of the body. The skin above it appears to be perfectly normal. Many of the articles concerning this condition have been in the foreign literature; however, the first report in 1885 was by an American, Weir Mitchell,1 whose description is excellent, and the photographs are remarkably good. While progressive lipodystrophy has been reported intermittently for 75 years, a variant, or different condition, known as lipoatrophic diabetes began to appear in the literature about 15 years ago. Although approximately 200 cases of progressive lipodystrophy have been reported, except for brief descriptions in Andrews' Diseases of the Skin,2 Pillsbury, Shelley, and Kligman's textbook of Dermatology,3 and the case of Paul Gross,4 no other references to it were found in the American dermatologic literature. Since this is not intended to be a References 1. Mitchell, S. W.: Singular Case of Absence of Adipose Matter in the Upper Half of the Body , Amer. J. Med. Sci. 90:105 ( (July) ) 1885.Crossref 2. Andrews, G. C.: Diseases of the Skin , Ed. 4, Philadelphia, W. B. Saunders Company, 1954. 3. Pillsbury, D. M.; Shelley, W. B., and Kligman, A. M.: Dermatology , Philadelphia, W. B. Saunders Company, 1956. 4. Gross, P.: Lipodystrophia Progressiva , Arch. Dermat. Syph. 36:432 ( (Aug.) ) 1937.Crossref 5. Weber, F. P.: Lipodystrophia Progressiva , Proc. Roy. Soc. Med. 10:81 ( (Feb. 23) ) 1917. 6. Reuben, M. S.; Zamkin, H. O., and Fox, H. R.: Lipodystrophia Progressiva , Arch. Pediat. 41:480 ( (July) ) 1924. 7. Coates, V.: Lipodystrophia , Brit. J. Child. Dis. 22:194 ( (July) -Sept.) 1925. 8. Currier, F. P., and Davis, D. B.: Progressive Lipodystrophy Appearing at Menopause , Amer. J. Med. Sci. 179:750 ( (June) ) 1930.Crossref 9. Harris, J. S., and Reiser, R.: Lipodystrophy: Report of a Case, with Metabolic Studies , Amer. J. Dis. Child. 59:143 ( (Jan.) ) 1940.Crossref 10. Jones, E.: Progressive Lipodystrophy , Brit. Med. J. 1:313 ( (Feb. 11) ) 1956.Crossref 11. Weber, F. P., and Gunewardene, T. H.: Sequel of Case of Lipodystrophia Progressiva , Brit. J. Child. Dis. 16:200 ( (Oct.) -Dec.) 1919. 12. Herrman, C.: Progressive Lipodystrophy , Arch. of Itern. Med. 17:516 ( (April) ) 1916.Crossref 13. Reuben, M. S.; Smith, A. de G., and Fox, H. R.: Lipodystrophia Progressiva: Report of 3 Cases , Arch. Pediat. 45:127 ( (Feb.) ) 1928. 14. Parmelee, A. H.: Lipodystrophy: A Report of 6 Cases in Children , J.A.M.A. 98:548 ( (Feb. 13) ) 1932.Crossref 15. Bigler, J. A.: Loss of Subcutaneous Fat of the Lower Extremities (Lipodystrophy) , J.A.M.A. 112:627 ( (Feb. 18) ) 1939.Crossref 16. Patton, E. F.: Lipodystrophy with Involvement Restricted to the 4 Extremities , Amer. J. Dis. Child. 70:31 ( (July) ) 1945. 17. Igersheimer, W. W.: Progressive Lipodystrophy: Etiologic Aspects and Report of a Case , Amer. J. Dis. Child. 75:206 ( (Feb.) ) 1948.Crossref 18. Maranon, G., and Soler, J. B.: Progressive Lipodystrophy and Hyperthyroidism , Endocrinology 10:1 ( (Jan.) -Feb.) 1926.Crossref 19. Murray, I.: Lipodystrophy , Brit. Med. J. 2: 1236 ( (Dec. 6) ) 1952.Crossref 20. Cohen, S. J., and Eis, B. M.: Lipodystrophy in Adults , Arch. Neurol. Psychiat. 32:184 ( (July) ) 1934.Crossref 21. Smith, H.: Progressive Lipodystrophy of the Lower Extremities: Report of a Case , Amer. J. Med. Sci. 179:758 ( (June) ) 1930.Crossref 22. Lawrence, R. D.: Three Human Types of Diabetes , Ann. of Intern. Med. 43:1199 ( (Dec.) ) 1955.Crossref 23. Williams, R. H.: Diabetes , New York, Paul B. Hoeber, Inc., 1960. 24. van Leeuwen, H. C.: Über familiäres Vorkommen von Lipodystrophia progressiva zusammen mit Otosklerose, Knochencysten und geistiger Debilität , Z. Klin. Med. 123:534, 1933. 25. Barraquer Ferre, L.: Pathogenesis of Progressive Cephalothoracic Lipodystrophy (Barraquer's Disease) , J. Nerv. Ment. Dis. 109:113 ( (Feb.) ) 1949.Crossref 26. Horton, B. T., and Emmett, J. L.: Atypical Syndromes in Uremia: Lipodystrophy Involving Lower Extremities , Med. Clin. N. Amer. 15-1505 ( (May) ) 1932. 27. Schwartz, R.; Schafer, I. A., and Renold, A. E.: Lipoatrophic Diabetes , Amer. J. Med. 28-973 ( (June) ) 1960. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Dermatology American Medical Association

Progressive Lipodystrophy and Lipoatrophic Diabetes: Review of the Literature and Case Reports

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Publisher
American Medical Association
Copyright
Copyright © 1961 American Medical Association. All Rights Reserved.
ISSN
0003-987X
eISSN
1538-3652
DOI
10.1001/archderm.1961.01580130037005
Publisher site
See Article on Publisher Site

Abstract

Abstract Progressive lipodystrophy is a relatively rare disease characterized by complete absence of subcutaneous fat in certain areas of the body. The skin above it appears to be perfectly normal. Many of the articles concerning this condition have been in the foreign literature; however, the first report in 1885 was by an American, Weir Mitchell,1 whose description is excellent, and the photographs are remarkably good. While progressive lipodystrophy has been reported intermittently for 75 years, a variant, or different condition, known as lipoatrophic diabetes began to appear in the literature about 15 years ago. Although approximately 200 cases of progressive lipodystrophy have been reported, except for brief descriptions in Andrews' Diseases of the Skin,2 Pillsbury, Shelley, and Kligman's textbook of Dermatology,3 and the case of Paul Gross,4 no other references to it were found in the American dermatologic literature. Since this is not intended to be a References 1. Mitchell, S. W.: Singular Case of Absence of Adipose Matter in the Upper Half of the Body , Amer. J. Med. Sci. 90:105 ( (July) ) 1885.Crossref 2. Andrews, G. C.: Diseases of the Skin , Ed. 4, Philadelphia, W. B. Saunders Company, 1954. 3. Pillsbury, D. M.; Shelley, W. B., and Kligman, A. M.: Dermatology , Philadelphia, W. B. Saunders Company, 1956. 4. Gross, P.: Lipodystrophia Progressiva , Arch. Dermat. Syph. 36:432 ( (Aug.) ) 1937.Crossref 5. Weber, F. P.: Lipodystrophia Progressiva , Proc. Roy. Soc. Med. 10:81 ( (Feb. 23) ) 1917. 6. Reuben, M. S.; Zamkin, H. O., and Fox, H. R.: Lipodystrophia Progressiva , Arch. Pediat. 41:480 ( (July) ) 1924. 7. Coates, V.: Lipodystrophia , Brit. J. Child. Dis. 22:194 ( (July) -Sept.) 1925. 8. Currier, F. P., and Davis, D. B.: Progressive Lipodystrophy Appearing at Menopause , Amer. J. Med. Sci. 179:750 ( (June) ) 1930.Crossref 9. Harris, J. S., and Reiser, R.: Lipodystrophy: Report of a Case, with Metabolic Studies , Amer. J. Dis. Child. 59:143 ( (Jan.) ) 1940.Crossref 10. Jones, E.: Progressive Lipodystrophy , Brit. Med. J. 1:313 ( (Feb. 11) ) 1956.Crossref 11. Weber, F. P., and Gunewardene, T. H.: Sequel of Case of Lipodystrophia Progressiva , Brit. J. Child. Dis. 16:200 ( (Oct.) -Dec.) 1919. 12. Herrman, C.: Progressive Lipodystrophy , Arch. of Itern. Med. 17:516 ( (April) ) 1916.Crossref 13. Reuben, M. S.; Smith, A. de G., and Fox, H. R.: Lipodystrophia Progressiva: Report of 3 Cases , Arch. Pediat. 45:127 ( (Feb.) ) 1928. 14. Parmelee, A. H.: Lipodystrophy: A Report of 6 Cases in Children , J.A.M.A. 98:548 ( (Feb. 13) ) 1932.Crossref 15. Bigler, J. A.: Loss of Subcutaneous Fat of the Lower Extremities (Lipodystrophy) , J.A.M.A. 112:627 ( (Feb. 18) ) 1939.Crossref 16. Patton, E. F.: Lipodystrophy with Involvement Restricted to the 4 Extremities , Amer. J. Dis. Child. 70:31 ( (July) ) 1945. 17. Igersheimer, W. W.: Progressive Lipodystrophy: Etiologic Aspects and Report of a Case , Amer. J. Dis. Child. 75:206 ( (Feb.) ) 1948.Crossref 18. Maranon, G., and Soler, J. B.: Progressive Lipodystrophy and Hyperthyroidism , Endocrinology 10:1 ( (Jan.) -Feb.) 1926.Crossref 19. Murray, I.: Lipodystrophy , Brit. Med. J. 2: 1236 ( (Dec. 6) ) 1952.Crossref 20. Cohen, S. J., and Eis, B. M.: Lipodystrophy in Adults , Arch. Neurol. Psychiat. 32:184 ( (July) ) 1934.Crossref 21. Smith, H.: Progressive Lipodystrophy of the Lower Extremities: Report of a Case , Amer. J. Med. Sci. 179:758 ( (June) ) 1930.Crossref 22. Lawrence, R. D.: Three Human Types of Diabetes , Ann. of Intern. Med. 43:1199 ( (Dec.) ) 1955.Crossref 23. Williams, R. H.: Diabetes , New York, Paul B. Hoeber, Inc., 1960. 24. van Leeuwen, H. C.: Über familiäres Vorkommen von Lipodystrophia progressiva zusammen mit Otosklerose, Knochencysten und geistiger Debilität , Z. Klin. Med. 123:534, 1933. 25. Barraquer Ferre, L.: Pathogenesis of Progressive Cephalothoracic Lipodystrophy (Barraquer's Disease) , J. Nerv. Ment. Dis. 109:113 ( (Feb.) ) 1949.Crossref 26. Horton, B. T., and Emmett, J. L.: Atypical Syndromes in Uremia: Lipodystrophy Involving Lower Extremities , Med. Clin. N. Amer. 15-1505 ( (May) ) 1932. 27. Schwartz, R.; Schafer, I. A., and Renold, A. E.: Lipoatrophic Diabetes , Amer. J. Med. 28-973 ( (June) ) 1960.

Journal

Archives of DermatologyAmerican Medical Association

Published: Jul 1, 1961

References

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