Key PointsQuestionIs progressive photoreceptor degeneration outside of geographic atrophy (GA) in eyes with nonexudative age-related macular degeneration evident and quantifiable? FindingsIn this cohort study, fully automated segmentation facilitated an accurate quantification of photoreceptor degeneration. Progressive degeneration of the outer nuclear layer and photoreceptor inner segments was evident, even accounting for age or distance to the GA boundary. MeaningProgressive alterations of photoreceptor laminae (exceeding GA spatially) were detectable and quantifiable. These findings support macula-wide photoreceptor degeneration as a candidate end point to monitor treatment effects beyond GA progression.
JAMA Ophthalmology – American Medical Association
Published: Oct 13, 2020