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Progression of Photoreceptor Degeneration in Geographic Atrophy Secondary to Age-related Macular Degeneration

Progression of Photoreceptor Degeneration in Geographic Atrophy Secondary to Age-related Macular... Key PointsQuestionIs progressive photoreceptor degeneration outside of geographic atrophy (GA) in eyes with nonexudative age-related macular degeneration evident and quantifiable? FindingsIn this cohort study, fully automated segmentation facilitated an accurate quantification of photoreceptor degeneration. Progressive degeneration of the outer nuclear layer and photoreceptor inner segments was evident, even accounting for age or distance to the GA boundary. MeaningProgressive alterations of photoreceptor laminae (exceeding GA spatially) were detectable and quantifiable. These findings support macula-wide photoreceptor degeneration as a candidate end point to monitor treatment effects beyond GA progression. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA Ophthalmology American Medical Association

Progression of Photoreceptor Degeneration in Geographic Atrophy Secondary to Age-related Macular Degeneration

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Publisher
American Medical Association
Copyright
Copyright 2020 American Medical Association. All Rights Reserved.
ISSN
2168-6165
eISSN
2168-6173
DOI
10.1001/jamaophthalmol.2020.2914
Publisher site
See Article on Publisher Site

Abstract

Key PointsQuestionIs progressive photoreceptor degeneration outside of geographic atrophy (GA) in eyes with nonexudative age-related macular degeneration evident and quantifiable? FindingsIn this cohort study, fully automated segmentation facilitated an accurate quantification of photoreceptor degeneration. Progressive degeneration of the outer nuclear layer and photoreceptor inner segments was evident, even accounting for age or distance to the GA boundary. MeaningProgressive alterations of photoreceptor laminae (exceeding GA spatially) were detectable and quantifiable. These findings support macula-wide photoreceptor degeneration as a candidate end point to monitor treatment effects beyond GA progression.

Journal

JAMA OphthalmologyAmerican Medical Association

Published: Oct 13, 2020

References