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PROGRESS IN CHEMOTHERAPY OF BACTERIAL AND OTHER DISEASES: WITH SPECIAL REFERENCE TO THE PRONTOSILS, SULFANILAMIDE AND SULFAPYRIDINE

PROGRESS IN CHEMOTHERAPY OF BACTERIAL AND OTHER DISEASES: WITH SPECIAL REFERENCE TO THE... Abstract Until the discovery of the effectiveness of the original prontosil (the hydrochloride of 4-sulfonamido-2',4'-diaminoazobenzene) in the treatment of streptococcic and staphylococcic infections the chemotherapy of systemic bacterial diseases was largely disappointing. It is true that certain dyes, like gentian violet and acriflavine base as well as various mercurial compounds, commanded considerable attention and extensive clinical trial, with encouraging results in individual cases; but in general, original hopes and expectations were not realized. Indeed, aside from the helpful effects of neoarsphenamine in the treatment of anthrax and the clinically inapplicable treatment of pneumococcic infections with ethylhydrocupreine (optochin) base and its soluble derivative ethylhydrocupreine hydrochloride, the only site in which bacteria have been found vulnerable by systemic chemical attack has been the urinary tract, where conditions are exceptional. But, as I wrote in 1936: I by no means share the skepticism so frequently expressed in regard to the future of the chemotherapy References 1. In the text and in the tables "original prontosil" refers to the hydrochloride of 4-sulfamido-2'-4'-diaminoazobenzene. "Soluble prontosil" and "neoprontosil" refer to disodium 4-sulfamidophenyl-2'-ao-7'-acetylamino-1'-hydroxynaphthalene3',6'-disulfonate, which is now marketed under the proprietary name "neoprontosil." Since this review was prepared, the Council on Pharmacy and Chemistry of the American Medical Association has adopted "azosulfamide" as the nonproprietary name for the latter compound. 2. Marshall and Long. Gailsford, Evans and Whitelaw. 3. Marshall. Stokinger. Bär. 4. Barker. Lee, Anderson and Chen. Speert. 5. Adair, Hesseltine and Hac. Stewart and Pratt. 6. Wien. Rimington and Hemmings. 7. Bigler, Clifton and Werner. Britton and Howkins. 8. Abramson, A. W., and Flacks, B.: Staphylococcal Septicemia Complicating Carbuncle of the Face , Lancet 2:1065, 1939.Crossref 9. Adair, F. L.; Hesseltine, H. C., and Hac, L. R.: Experimental Study of the Behavior of Sulfanilamide , J. A. M. A. 111:766 ( (Aug 27) ) 1938.Crossref 10. Agranat, A. L.; Dreosoti, A. A., and Ordman, D.: Treatment of Pneumonia with 2-(p-Aminobenzenesulphonamido) Pyridine (M. & B. 693) , Lancet 1:309,1939.Crossref 11. Treatment of Pneumonia with 2-(p-Aminobenzenesulphonamido) Pyridine (M. & B. 693) , Agranat Lancet 1:380, 1939.Crossref 12. Albright, F.; Dienes, L., and Sulkowitch, H. W.: Pyelonephritis with Nephrocalcinosis , J. A. M. A. 110:357 ( (June 4) ) 1938.Crossref 13. Allan, W. B.; Mayer, S., and Williams, R.: Pneumococcus Meningitis with Recovery , Am. J. M. Sc. 196:99, 1938.Crossref 14. Allison, S. T., and Myers, R.: Treatment of Pulmonary Tuberculosis with Sulfapyridine , J. A. M. A. 113:1631 ( (Oct. 28) ) 1939.Crossref 15. Alsted, G.: Type III Pneumococcal Pneumonia: Effect of M. & B. 693 , Lancet 1:869, 1939.Crossref 16. Anderson, E. D.: Hemolytic Streptococcus Meningitis: Report of a Case with Recovery After the Use of Prontosil and Sulfanilamide , J. A. M. A. 108:1591 ( (May 8) ) 1937.Crossref 17. Anderson, T.; Cooper, E. D.; Cairns, J. G., and Brown, D. R.: Sulfapyridine in Treatment of Pneumococcus (Type II) Pneumonia , Lancet 2:776, 1939.Crossref 18. Anderson, T. F., and Dowdeswell, R. M.: Treatment of Pneumonia with M. & B. 693 , Lancet 1:252, 1939.Crossref 19. Anwyl-Davies, T.: Sulphanilamide in the Treatment of Gonococcal Infections , Brit. M. J. 2:553, 1937.Crossref 20. Applebaum, E.: Sulfanilamide and Related Compounds in Treatment of Meningitis Secondary to Ear and Sinus Infections , Laryngoscope 48:482, 1938. 21. Appleyard, J.: Personal communication to the author. 22. Archer, H. E., and Discombe, G.: Sulphhaemoglobinaemia: Its Cause and Prevention, with Special Reference to Treatment with Sulphanilamide , Lancet 2:432, 1937.Crossref 23. Arnold, J. G.: Treatment of Hemolytic Streptococcic Meningitis with Para-Amino-Benzene Sulfonamide: Report of a Case with Recovery , Ann. Int. Med. 10:1198, 1937.Crossref 24. Bär, F.: Chemotherapeutische Versuche bei der experimentellen Infektion der Maus mit Lymphogranuloma inguinale , Klin. Wchnschr. 17:588, 1938.Crossref 25. Baker, J. K.: Clostridium Welchii Septicemia and Peritonitis in the Puerperium: Recovery After M. & B. 693 and Serum , Lancet 2:646, 1939.Crossref 26. Ballon, H. C., and Guernon, A.: The Effect of Sulfanilamide upon the Development of Experimental Tuberculosis in the Guinea Pig , J. Thoracic Surg. 8: 188, 1938. 27. Banks, H. S.: Serum and Sulfanilamide in Acute Meningococcal Meningitis: A Preliminary Survey Based on One Hundred and Thirteen Cases , Lancet 2:7, 1938.Crossref 28. Primary Peritonitis in Scarlet Fever Treated with Sodium Salt of M. & B. 693 , Banks Lancet 1:983, 1939.Crossref 29. Chemotherapy of Meningococcal Meningitis , Banks Lancet 2:921, 1939.Crossref 30. Bannick, E. G.; Brown, A. E., and Foster, F. P.: Therapeutic Effectiveness and Toxicity of Sulfanilamide and Several Related Compounds: Further Clinical Observations , J. A. M. A. 111:770 ( (Aug. 27) ) 1938.Crossref 31. Barbour, F. A., and Towsley, H. A.: Experience with Sulfanilamide in Treatment of Gonorrheal Ophthalmia , Arch. Ophth. 22:581 ( (Oct.) ) 1939.Crossref 32. Barer, H.: Typhoid Bacilluria Treated with Sulphanilamide , Lancet 2:964, 1937.Crossref 33. Barker, R. H.: Placental Transfer of Sulfanilamide , New England J. Med. 219: 42, 1938.Crossref 34. Barlow, O. W., and Homburger, E.: Specific Chemotherapy of Experimental Staphylococcus Infections with Thiazol Derivatives , Proc. Soc. Exper. Biol. & Med. 42:792, 1939. 35. Barnett, H. L.; Hartman, A. F.; Perley, A. M., and Ruhoff, M. B.: Treatment of Pneumococcic Infections in Infants and Children with Sulfanilamide , J. A. M. A. 112:518 ( (Feb. 11) ) 1939. 36. Basman, J., and Perley, A. M.: Report of Patients Treated with Sulfanilamide at the St. Louis Children's Hospital , J. Pediat. 11:212, 1937. 37. Batchelor, R. C. L.; Lees, R.; Murrell, M., and Braine, G. I. H.: 2-Sulphanilyl-Amidopyridine (M. & B. 693) in Treatment of Gonorrhea , Brit. M. J. 2: 1142, 1938. 38. 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PROGRESS IN CHEMOTHERAPY OF BACTERIAL AND OTHER DISEASES: WITH SPECIAL REFERENCE TO THE PRONTOSILS, SULFANILAMIDE AND SULFAPYRIDINE

Archives of Internal Medicine , Volume 65 (4) – Apr 1, 1940

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Copyright © 1940 American Medical Association. All Rights Reserved.
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0730-188X
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10.1001/archinte.1940.00190100012002
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Abstract

Abstract Until the discovery of the effectiveness of the original prontosil (the hydrochloride of 4-sulfonamido-2',4'-diaminoazobenzene) in the treatment of streptococcic and staphylococcic infections the chemotherapy of systemic bacterial diseases was largely disappointing. It is true that certain dyes, like gentian violet and acriflavine base as well as various mercurial compounds, commanded considerable attention and extensive clinical trial, with encouraging results in individual cases; but in general, original hopes and expectations were not realized. Indeed, aside from the helpful effects of neoarsphenamine in the treatment of anthrax and the clinically inapplicable treatment of pneumococcic infections with ethylhydrocupreine (optochin) base and its soluble derivative ethylhydrocupreine hydrochloride, the only site in which bacteria have been found vulnerable by systemic chemical attack has been the urinary tract, where conditions are exceptional. But, as I wrote in 1936: I by no means share the skepticism so frequently expressed in regard to the future of the chemotherapy References 1. In the text and in the tables "original prontosil" refers to the hydrochloride of 4-sulfamido-2'-4'-diaminoazobenzene. "Soluble prontosil" and "neoprontosil" refer to disodium 4-sulfamidophenyl-2'-ao-7'-acetylamino-1'-hydroxynaphthalene3',6'-disulfonate, which is now marketed under the proprietary name "neoprontosil." Since this review was prepared, the Council on Pharmacy and Chemistry of the American Medical Association has adopted "azosulfamide" as the nonproprietary name for the latter compound. 2. Marshall and Long. Gailsford, Evans and Whitelaw. 3. Marshall. Stokinger. Bär. 4. Barker. Lee, Anderson and Chen. Speert. 5. Adair, Hesseltine and Hac. Stewart and Pratt. 6. Wien. Rimington and Hemmings. 7. Bigler, Clifton and Werner. Britton and Howkins. 8. Abramson, A. W., and Flacks, B.: Staphylococcal Septicemia Complicating Carbuncle of the Face , Lancet 2:1065, 1939.Crossref 9. Adair, F. L.; Hesseltine, H. C., and Hac, L. R.: Experimental Study of the Behavior of Sulfanilamide , J. A. M. A. 111:766 ( (Aug 27) ) 1938.Crossref 10. Agranat, A. L.; Dreosoti, A. A., and Ordman, D.: Treatment of Pneumonia with 2-(p-Aminobenzenesulphonamido) Pyridine (M. & B. 693) , Lancet 1:309,1939.Crossref 11. Treatment of Pneumonia with 2-(p-Aminobenzenesulphonamido) Pyridine (M. & B. 693) , Agranat Lancet 1:380, 1939.Crossref 12. Albright, F.; Dienes, L., and Sulkowitch, H. W.: Pyelonephritis with Nephrocalcinosis , J. A. M. A. 110:357 ( (June 4) ) 1938.Crossref 13. Allan, W. B.; Mayer, S., and Williams, R.: Pneumococcus Meningitis with Recovery , Am. J. M. Sc. 196:99, 1938.Crossref 14. Allison, S. T., and Myers, R.: Treatment of Pulmonary Tuberculosis with Sulfapyridine , J. A. M. A. 113:1631 ( (Oct. 28) ) 1939.Crossref 15. 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Journal

Archives of Internal MedicineAmerican Medical Association

Published: Apr 1, 1940

References