ORIGINAL INVESTIGATION Prognostic Implications of the Urinary Albumin to Creatinine Ratio in Veterans of Different Ages With Diabetes Ann M. O’Hare, MD, MA; Susan M. Hailpern, DrPH, MS; Meda E. Pavkov, MD, PhD; Nilka Rios-Burrows, MPH; Indra Gupta, PhD; Charles Maynard, PhD; Jeff Todd-Stenberg, BA; Rudolph A. Rodriguez, MD; Brenda R. Hemmelgarn, MD, PhD; Rajiv Saran, MD; Desmond E. Williams, MD, PhD Background: Albuminuria is associated with an in- tients with an eGFR less than 60 mL/min/1.73 m , 72% creased risk of death independent of level of renal func- of those younger than 65 years, 74% of those 65 to 74 tion. Whether this association is similar for adults of all years old, and 59% of those 75 years and older had an ages is not known. eGFR of 45 to 59 mL/min/1.73 m . In all age groups, less than 35% of these patients had albuminuria (ie, ACR30 Methods: We examined the association between the al- mg/g). In patients 75 years and older, the ACR was in- bumin to creatinine ratio (ACR) and all-cause mortality dependently associated with an increased risk of death after stratification by estimated glomerular filtration rate at all levels of eGFR after adjusting
JAMA Internal Medicine – American Medical Association
Published: Jun 14, 2010
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