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Prognostic Factors in Pneumococcal Meningitis

Prognostic Factors in Pneumococcal Meningitis Abstract DESPITE the availability of an effective therapy, the prognosis of pneumococcal meningitis has been quite variable from one institution to another, even in recent years. Lepper and Spies 1 reported a 10% case fatality rate for 68 patients. Olsson et al2 recorded 65% deaths in 43 cases. Swartz and Dodge 3 had 29% mortality for 56 cases. Since the therapeutic regimens in these hospitals were similar, the differences in outcome must have been due to differences in case material. For example, age is an important characteristic in relation to results. The series with the lowest fatality rate 1 had a large proportion of young patients while the series with the highest mortality rate 2 had many old patients. Barring changes in admission policy, trends in prognosis for a given disease at a single institution over a period of time are likely to reflect the influence of changes in therapy References 1. Lepper, M.H., and Spies, H.W.: Treatment of Pneumococcic Meningitis , Arch Intern Med 104: 253-259 ( (Aug) ) 1959.Crossref 2. Olsson, R.A.; Kirby, J.C.; and Romansky, M.J.: Pneumococcal Meningitis in the Adult: Clinical, Therapeutic and Prognostic Aspects in Forty-three Patients , Ann Intern Med 55:545-549 ( (Oct) ) 1961.Crossref 3. Swartz, M.N., and Dodge, P.R.: Bacterial Meningitis: A Review of Selected Aspects , N Eng J Med 272:725-731, 779-787, 842-848, 898-902, 954-960, 1003-1010 and ( (April 8) , 15, 22, 29; May 6, 13) 1965.Crossref 4. Alexander, J.D., Jr.; Flippin, H.F.; and Eisenberg, G.M.: Pneumococcic Meningitis; Study of One Hundred Two Cases , Arch Intern Med 91:440-447 ( (April) ) 1953.Crossref 5. "Significance Limits for the Four-Fold Table Test," Documenta Geigy Scientific Tables , ed 6, Ardsley, NY: Geigy Pharmaceuticals, 1962, pp 109-123. 6. Haggerty, R.J., and Ziai, M.: Acute Bacterial Meningitis , Advances Pediat 13:129-181, 1964. 7. Austrian, R.: The Role of Toxemia and of Neural Injury in the Outcome of Pneumococcal Meningitis , Amer J Med Sci 247:257-262 ( (March) ) 964.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Internal Medicine American Medical Association

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Publisher
American Medical Association
Copyright
Copyright © 1967 American Medical Association. All Rights Reserved.
ISSN
0003-9926
eISSN
1538-3679
DOI
10.1001/archinte.1967.00300040001001
Publisher site
See Article on Publisher Site

Abstract

Abstract DESPITE the availability of an effective therapy, the prognosis of pneumococcal meningitis has been quite variable from one institution to another, even in recent years. Lepper and Spies 1 reported a 10% case fatality rate for 68 patients. Olsson et al2 recorded 65% deaths in 43 cases. Swartz and Dodge 3 had 29% mortality for 56 cases. Since the therapeutic regimens in these hospitals were similar, the differences in outcome must have been due to differences in case material. For example, age is an important characteristic in relation to results. The series with the lowest fatality rate 1 had a large proportion of young patients while the series with the highest mortality rate 2 had many old patients. Barring changes in admission policy, trends in prognosis for a given disease at a single institution over a period of time are likely to reflect the influence of changes in therapy References 1. Lepper, M.H., and Spies, H.W.: Treatment of Pneumococcic Meningitis , Arch Intern Med 104: 253-259 ( (Aug) ) 1959.Crossref 2. Olsson, R.A.; Kirby, J.C.; and Romansky, M.J.: Pneumococcal Meningitis in the Adult: Clinical, Therapeutic and Prognostic Aspects in Forty-three Patients , Ann Intern Med 55:545-549 ( (Oct) ) 1961.Crossref 3. Swartz, M.N., and Dodge, P.R.: Bacterial Meningitis: A Review of Selected Aspects , N Eng J Med 272:725-731, 779-787, 842-848, 898-902, 954-960, 1003-1010 and ( (April 8) , 15, 22, 29; May 6, 13) 1965.Crossref 4. Alexander, J.D., Jr.; Flippin, H.F.; and Eisenberg, G.M.: Pneumococcic Meningitis; Study of One Hundred Two Cases , Arch Intern Med 91:440-447 ( (April) ) 1953.Crossref 5. "Significance Limits for the Four-Fold Table Test," Documenta Geigy Scientific Tables , ed 6, Ardsley, NY: Geigy Pharmaceuticals, 1962, pp 109-123. 6. Haggerty, R.J., and Ziai, M.: Acute Bacterial Meningitis , Advances Pediat 13:129-181, 1964. 7. Austrian, R.: The Role of Toxemia and of Neural Injury in the Outcome of Pneumococcal Meningitis , Amer J Med Sci 247:257-262 ( (March) ) 964.Crossref

Journal

Archives of Internal MedicineAmerican Medical Association

Published: Nov 1, 1967

References