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Problematic End Points in a Trial of Topical Fluorouracil, 5%, for Chemoprevention of Keratinocyte Carcinoma

Problematic End Points in a Trial of Topical Fluorouracil, 5%, for Chemoprevention of... Letters Institute of Medical Education and Research, Chandigarh, India (Vishwajeet, etiology can cause grotesque enlargement of the affected body 2 Saikia); Department of Pediatrics, Postgraduate Institute of Medical Education part, referred to as elephantiasis. The impeded lymphatic and Research, Chandigarh, India (Panigrahi). drainage in elephantiasis can rarely manifest on the skin with Corresponding Author: Muthu Sendhil Kumaran, MD, DNB, MNAMS, translucent papulovesicular lesions (acquired lymphangiec- Department of Dermatology, Venereology, and Leprology, Postgraduate tasia), which eventually progress to confluent, hyperkera- Institute of Medical Education and Research, Sector 12, Chandigarh, 160012 India (drsen_2000@yahoo.com). totic, macerated, cobblestoned plaques resembling moss, called Published Online: April 18, 2018. doi:10.1001/jamadermatol.2018.0210 ENV. Elephantiasis nostras verrucosa commonly occurs over the lower limbs, although other body sites can rarely be af- Conflict of Interest Disclosures: None reported. fected. One previous report describes the development of scro- 1. Van Balkom ID, Alders M, Allanson J, et al. Lymphedema-lymphangiectasia- mental retardation (Hennekam) syndrome: a review. Am J Med Genet. 2002;112 tal lymphangiectasia in Hennekam syndrome. (4):412-421. Elephantiasis nostras verrucosa should be differentiated 2. Sisto K, Khachemoune A. Elephantiasis nostras verrucosa: a review. Am J Clin from close clinical simulators like verruca vulgaris (espe- Dermatol. 2008;9(3):141-146. cially over periungual areas) and http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA Dermatology American Medical Association

Problematic End Points in a Trial of Topical Fluorouracil, 5%, for Chemoprevention of Keratinocyte Carcinoma

JAMA Dermatology , Volume 154 (7) – Jul 13, 2018

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Publisher
American Medical Association
Copyright
Copyright 2018 American Medical Association. All Rights Reserved.
ISSN
2168-6068
eISSN
2168-6084
DOI
10.1001/jamadermatol.2018.1229
Publisher site
See Article on Publisher Site

Abstract

Letters Institute of Medical Education and Research, Chandigarh, India (Vishwajeet, etiology can cause grotesque enlargement of the affected body 2 Saikia); Department of Pediatrics, Postgraduate Institute of Medical Education part, referred to as elephantiasis. The impeded lymphatic and Research, Chandigarh, India (Panigrahi). drainage in elephantiasis can rarely manifest on the skin with Corresponding Author: Muthu Sendhil Kumaran, MD, DNB, MNAMS, translucent papulovesicular lesions (acquired lymphangiec- Department of Dermatology, Venereology, and Leprology, Postgraduate tasia), which eventually progress to confluent, hyperkera- Institute of Medical Education and Research, Sector 12, Chandigarh, 160012 India (drsen_2000@yahoo.com). totic, macerated, cobblestoned plaques resembling moss, called Published Online: April 18, 2018. doi:10.1001/jamadermatol.2018.0210 ENV. Elephantiasis nostras verrucosa commonly occurs over the lower limbs, although other body sites can rarely be af- Conflict of Interest Disclosures: None reported. fected. One previous report describes the development of scro- 1. Van Balkom ID, Alders M, Allanson J, et al. Lymphedema-lymphangiectasia- mental retardation (Hennekam) syndrome: a review. Am J Med Genet. 2002;112 tal lymphangiectasia in Hennekam syndrome. (4):412-421. Elephantiasis nostras verrucosa should be differentiated 2. Sisto K, Khachemoune A. Elephantiasis nostras verrucosa: a review. Am J Clin from close clinical simulators like verruca vulgaris (espe- Dermatol. 2008;9(3):141-146. cially over periungual areas) and

Journal

JAMA DermatologyAmerican Medical Association

Published: Jul 13, 2018

References