Access the full text.
Sign up today, get DeepDyve free for 14 days.
Michelle Garrison, D. Christakis (2001)
A systematic review of treatments for infant colic.Pediatrics, 106 1 Pt 2
P. Lucassen, W. Assendelft, J. Eijk, J. Gubbels, A. Douwes, W. Geldrop (2001)
Systematic review of the occurrence of infantile colic in the communityArchives of Disease in Childhood, 84
B. Danielsson, C. Hwang (1985)
Treatment of Infantile Colic with Surface Active Substance (Simethicone)Acta Pædiatrica, 74
Justine Cohen-Silver, S. Ratnapalan (2009)
Management of Infantile Colic: A ReviewClinical Pediatrics, 48
K. Kukkonen, E. Savilahti, T. Haahtela, K. Juntunen‐Backman, R. Korpela, T. Poussa, T. Tuure, M. Kuitunen (2008)
Long-Term Safety and Impact on Infection Rates of Postnatal Probiotic and Prebiotic (Synbiotic) Treatment: Randomized, Double-Blind, Placebo-Controlled TrialPediatrics, 122
D. Moher, A. Liberati, J. Tetzlaff, D. Altman (2009)
Preferred reporting items for systematic reviews and meta-analyses: the PRISMA StatementOpen Medicine, 3
A. Vlieger, Afke Robroch, S. Buuren, J. Kiers, G. Rijkers, M. Benninga, R. Biesebeke (2009)
Tolerance and safety of Lactobacillus paracasei ssp. paracasei in combination with Bifidobacterium animalis ssp. lactis in a prebiotic-containing infant formula: a randomised controlled trial.The British journal of nutrition, 102 6
R. Barr, R. Trent, Julie Cross (2006)
Age-related incidence curve of hospitalized Shaken Baby Syndrome cases: convergent evidence for crying as a trigger to shaking.Child abuse & neglect, 30 1
F. Indrio, G. Riezzo, F. Raimondi, M. Bisceglia, L. Cavallo, R. Francavilla (2008)
The effects of probiotics on feeding tolerance, bowel habits, and gastrointestinal motility in preterm newborns.The Journal of pediatrics, 152 6
S. Mentula, T. Tuure, R. Koskenala, R. Korpela, E. Könönen (2008)
Microbial composition and fecal fermentation end products from colicky infants – a probiotic supplementation pilotMicrobial Ecology in Health and Disease, 20
F. Savino, E. Castagno, R. Bretto, C. Brondello, E. Palumeri, R. Oggero (2005)
A prospective 10‐year study on children who had severe infantile colicActa Pædiatrica, 94
M. Rinne, M. Kalliomäki, S. Salminen, E. Isolauri (2006)
Probiotic Intervention in the First Months of Life: Short-Term Effects on Gastrointestinal Symptoms and Long-Term Effects on Gut MicrobiotaJournal of Pediatric Gastroenterology and Nutrition, 43
T. Metcalf, T. Irons, L. Sher, P. Young (1994)
Simethicone in the treatment of infant colic: a randomized, placebo-controlled, multicenter trial.Pediatrics, 94 1
Ronald Barr, M. Kramer, C. Boisjoly, L. McVey-White, Pless Ib (1988)
Parental diary of infant cry and fuss behaviour.Archives of Disease in Childhood, 63
J. Rozé, S. Barbarot, M. Butel, N. Kapel, A. Waligora-Dupriet, I. Montgolfier, M. Leblanc, N. Godon, P. Soulaines, D. Darmaun, M. Rivero, C. Dupont (2011)
An α-lactalbumin-enriched and symbiotic-supplemented v. a standard infant formula: a multicentre, double-blind, randomised trialBritish Journal of Nutrition, 107
N. Vendt, H. Grunberg, T. Tuure, O. Malminiemi, E. Wuolijoki, V. Tillmann, E. Sepp, R. Korpela (2006)
Growth during the first 6 months of life in infants using formula enriched with Lactobacillus rhamnosus GG: double-blind, randomized trial.Journal of human nutrition and dietetics : the official journal of the British Dietetic Association, 19 1
D. Hill, N. Roy, R. Heine, C. Hosking, D. Francis, J. Brown, B. Speirs, Joel Sadowsky, J. Carlin (2005)
Effect of a Low-Allergen Maternal Diet on Colic Among Breastfed Infants: A Randomized, Controlled TrialPediatrics, 116
G. Biasucci, Belinda Benenati, L. Morelli, Elena Bessi, G. Boehm (2008)
Cesarean delivery may affect the early biodiversity of intestinal bacteria.The Journal of nutrition, 138 9
F. Savino, F. Cresi, S. Pautasso, E. Palumeri, V. Tullio, J. Roana, L. Silvestro, R. Oggero (2004)
Intestinal microflora in breastfed colicky and non‐colicky infantsActa Paediatrica, 93
D. Wolke, P. Rizzo, Sarah Woods (2002)
Persistent infant crying and hyperactivity problems in middle childhood.Pediatrics, 109 6
L. Lehtonen, H. Korvenranta, E. Eerola (1994)
Intestinal Microflora in Colicky and Noncolicky Infants: Bacterial Cultures and Gas‐Liquid ChromatographyJournal of Pediatric Gastroenterology and Nutrition, 19
A. Pärtty, M. Kalliomäki, A. Endo, S. Salminen, E. Isolauri (2012)
Compositional Development of Bifidobacterium and Lactobacillus Microbiota Is Linked with Crying and Fussing in Early InfancyPLoS ONE, 7
P. Lucassen, W. Assendelft, J. Gubbels, J. Eijk, A. Douwes (2000)
Infantile colic: crying time reduction with a whey hydrolysate: A double-blind, randomized, placebo-controlled trial.Pediatrics, 106 6
C. Dupont, M. Rivero, C. Grillon, N. Belaroussi, A. Kalindjian, V. Marín (2010)
α-Lactalbumin-enriched and probiotic-supplemented infant formula in infants with colic: growth and gastrointestinal toleranceEuropean Journal of Clinical Nutrition, 64
M. Brown, R. Heine, Brigid Jordan (2009)
Health and well‐being in school‐age children following persistent crying in infancyJournal of Paediatrics and Child Health, 45
C. McMahon, B. Barnett, N. Kowalenko, C. Tennant, Neville Don (2001)
Postnatal Depression, Anxiety and Unsettled Infant BehaviourAustralian and New Zealand Journal of Psychiatry, 35
F. Savino, E. Pelle, E. Palumeri, R. Oggero, R. Miniero (2007)
Lactobacillus reuteri (American Type Culture Collection Strain 55730) Versus Simethicone in the Treatment of Infantile Colic: A Prospective Randomized StudyPediatrics, 119
Takeshi Kamiya, Lu Wang, P. Forsythe, Gudrun Goettsche, Y. Mao, Yufang Wang, G. Tougas, J. Bienenstock (2005)
Inhibitory effects of Lactobacillus reuteri on visceral pain induced by colorectal distension in Sprague-Dawley ratsGut, 55
F. Savino, Lisa Cordisco, V. Tarasco, E. Palumeri, R. Calabrese, R. Oggero, S. Roos, D. Matteuzzi (2010)
Lactobacillus reuteri DSM 17938 in Infantile Colic: A Randomized, Double-Blind, Placebo-Controlled TrialPediatrics, 126
Z. Weizman, A. Alsheikh (2006)
Safety and Tolerance of a Probiotic Formula in Early Infancy Comparing Two Probiotic Agents: A Pilot StudyJournal of the American College of Nutrition, 25
H. Szajewska, E. Gyrczuk, A. Horváth (2013)
Lactobacillus reuteri DSM 17938 for the management of infantile colic in breastfed infants: a randomized, double-blind, placebo-controlled trial.The Journal of pediatrics, 162 2
P. Lucassen, W. Assendelft (2001)
Systematic review of treatments for infant colic [letter]Pediatrics, 108
F. Penna, L. Péret, L. Vieira, J. Nicoli (2008)
Probiotics and mucosal barrier in childrenCurrent Opinion in Clinical Nutrition and Metabolic Care, 11
D. Altman, J. Bland (2011)
How to obtain the confidence interval from a P valueBMJ : British Medical Journal, 343
O. Thompson-Chagoyán, Matteo Fallani, J. Maldonado, J. Vieites, S. Khanna, C. Edwards, J. Doré, Á. Gil (2011)
Faecal Microbiota and Short-Chain Fatty Acid Levels in Faeces from Infants with Cow‘s Milk Protein AllergyInternational Archives of Allergy and Immunology, 156
Xuelian Ma, Y. Mao, B. Wang, J. Huizinga, J. Bienenstock, W. Kunze (2009)
Lactobacillus reuteri ingestion prevents hyperexcitability of colonic DRG neurons induced by noxious stimuli.American journal of physiology. Gastrointestinal and liver physiology, 296 4
I. Jakobsson, L. Lothe, D. Ley, MW Borschel (2000)
Effectiveness of casein hydrolysate feedings in infants with colicActa Pædiatrica, 89
ImportanceExcessive infant crying is common, distressing, but without proven effective prevention or management options. Probiotics may be a promising solution. ObjectiveTo examine whether probiotics are effective in the prevention/management of crying (“colic”) in infants 3 months or younger. Data SourcesA systematic search of MEDLINE, EMBASE, and the Cochrane Library, supplemented by the metaRegister of Controlled Trials. Study SelectionStudies that randomized infants 3 months or younger to oral probiotics vs placebo or no or standard treatment with the outcome of infant crying, measured as the duration or number of episodes of infant crying/distress or diagnosis of “infant colic.” Twelve of the 1180 initially identified studies were selected. Data Extraction and SynthesisThis review/meta-analysis was conducted according to guidelines from the Cochrane Handbook for Systematic Reviews of Interventions, with reporting following the Preferred Reporting Items for Systematic Reviews and Meta-analyses guidelines. Data were independently extracted by 3 of us. Main Outcome(s) and Measure(s)Infant crying, measured as the duration or number of episodes of infant crying/distress, or diagnosis of “infant colic.” ResultsOf the 12 trials (1825 infants) reviewed, 6 suggested probiotics reduced crying, and 6 did not. Three of the 5 management trials concluded probiotics effectively treat colic in breastfed babies; 1 suggested possible effectiveness in formula-fed babies with colic, and 1 suggested ineffectiveness in breastfed babies with colic. Meta-analysis of 3 small trials of breastfed infants with colic found that Lactobacillus reuteri markedly reduced crying time at 21 days (median difference, −65 minutes/d; 95% CI, −86 to −44). However, all trials had potential biases. Meanwhile, of 7 prevention trials, 2 suggested possible benefits. Considerable variability in the study populations, study type, delivery mode/dose of probiotic supplementation, and outcomes precluded meta-analysis. Conclusions and RelevanceAlthough L reuteri may be effective as treatment for crying in exclusively breastfed infants with colic, there is still insufficient evidence to support probiotic use to manage colic, especially in formula-fed infants, or to prevent infant crying. Results from larger rigorously designed studies applicable to all crying infants will help draw more definitive conclusions.
JAMA Pediatrics – American Medical Association
Published: Dec 1, 2013
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.