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Primary Treatment of Choriocarcinoma With Methotrexate

Primary Treatment of Choriocarcinoma With Methotrexate Abstract IN RECENT years there has been a surge of interest in choriocarcinoma due mainly to the work of Dr. R. Hertz and M. C. Li and their associates with chemotherapeutic agents, particularly methotrexate. Hertz has reported complete remission of one to five year's duration in 47.5% of 63 patients treated with methotrexate.6 Some of the remainder have shown at least transient response to vinblastine sulfate, an oncolytic alkaloid. Presently work is being carried out with the primary use of dactinomycin. The bizarre behavior of trophoblastic growths has been emphasized by many authors.1,2,4,5,7,8,9 This makes premature and overzealous interpretation of new therapeutic measures hazardous. In reviewing the cases of the Albert Mathieu Chorioepithelioma Registry, Brewer and associates3 found five-year survival of 21 out of 147 patients with choriocarcinoma who were treated surgically. Of these 21 patients, six had metastatic lesions. This presentation aims to contribute two cases of References 1. Bardawil, W.A.; Hertig, A.T.; and Velardo, J.T.: Regression of Trophoblast: I. Hydatidiform Mole: A Case of Unusual Features, Possibly Metastasis and Regression: Review of Literature , Obstet Gynec 10:614, 1957.Crossref 2. Bardawil, W.A., and Toy, B.L.: Choriocarcinoma: Problems of Immunity and Spontaneous Regression , Ann NY Acad Sci 80:197, 1959.Crossref 3. Brewer, J.I.; Rhinehart, J.J.; and Dunbar, R.W.: Choriocarcinoma: A Report of the 5 or More Years' Survival From the Albert Mathieu Chorionepithelioma Registry , Amer J Obstet Gynec 81:574-583, 1961. 4. Delfs, E.: Quantitative Chorionic Gonadotrophin: Prognostic Value in Hydatidiform Mole and Chorionepithelioma , Obstet Gynec 9:1, 1957. 5. Dinh, De T., and Minh, H.N.: Hydathidiform Mole With Recurrent Vaginal Metastasis , Amer J Obstet Gynec 82:660, 1961. 6. Hertz, R.; Lewis, J., Jr.; and Lipsett, M.B.: Five Years' Experience With the Chemotherapy of Metastatic Choriocarcinoma and Related Trophoblastic Tumors in Women , Amer J Obstet Gynec 82:631-640 ( (Sept) ) 1961. 7. Kistner, R.W.: Malignant Syncytioma Following Benign Hydatidiform Mole , Amer J Obstet Gynec 63:888, 1952. 8. Novak, E., and Seah, C.S.: Benign Trophoblastic Lesions in Mathieu Chorionepithelioma Registry (Hydatidiform Mole, Syncytial Endometritis) , Amer J Obstet Gynec 68:376, 1954. 9. Schmauch, G.: The Histologic and Clinical Significance of the Malignant Chorioepithelioma: Remarks on Spontaneous Recovery Therefrom Differentiation Between Benign and Malignant Chorioepithelial Proliferations: A Review of 206 Cases , Surg Gynec Obstet 5:259, 1907. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Surgery American Medical Association

Primary Treatment of Choriocarcinoma With Methotrexate

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Publisher
American Medical Association
Copyright
Copyright © 1966 American Medical Association. All Rights Reserved.
ISSN
0004-0010
eISSN
1538-3644
DOI
10.1001/archsurg.1966.01320200141021
Publisher site
See Article on Publisher Site

Abstract

Abstract IN RECENT years there has been a surge of interest in choriocarcinoma due mainly to the work of Dr. R. Hertz and M. C. Li and their associates with chemotherapeutic agents, particularly methotrexate. Hertz has reported complete remission of one to five year's duration in 47.5% of 63 patients treated with methotrexate.6 Some of the remainder have shown at least transient response to vinblastine sulfate, an oncolytic alkaloid. Presently work is being carried out with the primary use of dactinomycin. The bizarre behavior of trophoblastic growths has been emphasized by many authors.1,2,4,5,7,8,9 This makes premature and overzealous interpretation of new therapeutic measures hazardous. In reviewing the cases of the Albert Mathieu Chorioepithelioma Registry, Brewer and associates3 found five-year survival of 21 out of 147 patients with choriocarcinoma who were treated surgically. Of these 21 patients, six had metastatic lesions. This presentation aims to contribute two cases of References 1. Bardawil, W.A.; Hertig, A.T.; and Velardo, J.T.: Regression of Trophoblast: I. Hydatidiform Mole: A Case of Unusual Features, Possibly Metastasis and Regression: Review of Literature , Obstet Gynec 10:614, 1957.Crossref 2. Bardawil, W.A., and Toy, B.L.: Choriocarcinoma: Problems of Immunity and Spontaneous Regression , Ann NY Acad Sci 80:197, 1959.Crossref 3. Brewer, J.I.; Rhinehart, J.J.; and Dunbar, R.W.: Choriocarcinoma: A Report of the 5 or More Years' Survival From the Albert Mathieu Chorionepithelioma Registry , Amer J Obstet Gynec 81:574-583, 1961. 4. Delfs, E.: Quantitative Chorionic Gonadotrophin: Prognostic Value in Hydatidiform Mole and Chorionepithelioma , Obstet Gynec 9:1, 1957. 5. Dinh, De T., and Minh, H.N.: Hydathidiform Mole With Recurrent Vaginal Metastasis , Amer J Obstet Gynec 82:660, 1961. 6. Hertz, R.; Lewis, J., Jr.; and Lipsett, M.B.: Five Years' Experience With the Chemotherapy of Metastatic Choriocarcinoma and Related Trophoblastic Tumors in Women , Amer J Obstet Gynec 82:631-640 ( (Sept) ) 1961. 7. Kistner, R.W.: Malignant Syncytioma Following Benign Hydatidiform Mole , Amer J Obstet Gynec 63:888, 1952. 8. Novak, E., and Seah, C.S.: Benign Trophoblastic Lesions in Mathieu Chorionepithelioma Registry (Hydatidiform Mole, Syncytial Endometritis) , Amer J Obstet Gynec 68:376, 1954. 9. Schmauch, G.: The Histologic and Clinical Significance of the Malignant Chorioepithelioma: Remarks on Spontaneous Recovery Therefrom Differentiation Between Benign and Malignant Chorioepithelial Proliferations: A Review of 206 Cases , Surg Gynec Obstet 5:259, 1907.

Journal

Archives of SurgeryAmerican Medical Association

Published: Feb 1, 1966

References