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Primary Mycobacterial Infection of the Pharynx

Primary Mycobacterial Infection of the Pharynx Abstract The pathogenesis of mycobacterial lymphadenitis is not completely understood despite the association of Mycobacterium tuberculosis with scrofula for centuries1 and of the "atypical" mycobacteria, or mycobacteria other than tuberculosis (MOTT), with cervical adenitis for more than 20 years.2 Because of the present day rarity of mycobacterial disease, the role of these microorganisms in childhood lymphadenitis is frequently overlooked. This report describes a patient whose unique site of infection and rapid progression of symptoms prompted an evaluation for lymphoma. Although the role of primary oral infections have been implicated in the pathogenesis of MOTT cervical adenitis,3 this patient represents the first case in which the relationship has been confirmed histologically and microbiologically. Report of a Case.—A 7-year-old girl was admitted to the University of Virginia Hospital with a five-week history of fever, malaise, sore throat, and painless, cervical lymphadenopathy. Her medical history was unremarkable except for a References 1. Cantrell RW, Jensen JH, Reid D: Diagnosis and management of tuberculous cervical adenitis . Arch Otolaryngol 101:53-57, 1975.Crossref 2. Prissick FH, Masson AM: Cervical lymphadenitis in children caused by chromogenic mycobacteria . Can Med Assoc J 75:798-803, 1956. 3. MacKellar A: Diagnosis and management of atypical mycobacterial lymphadenitis in children . J Pediatr Surg 11:85-89, 1976.Crossref 4. Lee KJ, Fidler W, Kelly J, et al: Retropharyngeal swelling of unexpected etiologies . Conn Med 38:452-457, 1974. 5. Neumann JL, Schlueter DP: Retropharyngeal abscess as the presenting feature of tuberculosis of the cervical spine . Am Rev Respir Dis 110:508-511, 1974. 6. Lincoln EM, Gilbert LA: Disease in children due to mycobacteria other than Mycobacterium tuberculosis . Am Rev Respir Dis 105:683-714, 1972. 7. Barton LL, Feigin RD: Childhood cervical lymphadenitis: A reappraisal . J Pediatr 84:846-852, 1974.Crossref 8. Belin RP, Richardson JD, Richardson DL, et al: Diagnosis and management of scrofula in children . J Pediatr Surg 9:103-107, 1974.Crossref 9. Mandell F, Wright PF: Treatment of atypical mycobacterial cervical adenitis with rifampin . Pediatrics 55:39-43, 1975. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of Diseases of Children American Medical Association

Primary Mycobacterial Infection of the Pharynx

Primary Mycobacterial Infection of the Pharynx

Abstract

Abstract The pathogenesis of mycobacterial lymphadenitis is not completely understood despite the association of Mycobacterium tuberculosis with scrofula for centuries1 and of the "atypical" mycobacteria, or mycobacteria other than tuberculosis (MOTT), with cervical adenitis for more than 20 years.2 Because of the present day rarity of mycobacterial disease, the role of these microorganisms in childhood lymphadenitis is frequently overlooked. This report describes a patient whose...
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Publisher
American Medical Association
Copyright
Copyright © 1978 American Medical Association. All Rights Reserved.
ISSN
0002-922X
DOI
10.1001/archpedi.1978.02120270108026
Publisher site
See Article on Publisher Site

Abstract

Abstract The pathogenesis of mycobacterial lymphadenitis is not completely understood despite the association of Mycobacterium tuberculosis with scrofula for centuries1 and of the "atypical" mycobacteria, or mycobacteria other than tuberculosis (MOTT), with cervical adenitis for more than 20 years.2 Because of the present day rarity of mycobacterial disease, the role of these microorganisms in childhood lymphadenitis is frequently overlooked. This report describes a patient whose unique site of infection and rapid progression of symptoms prompted an evaluation for lymphoma. Although the role of primary oral infections have been implicated in the pathogenesis of MOTT cervical adenitis,3 this patient represents the first case in which the relationship has been confirmed histologically and microbiologically. Report of a Case.—A 7-year-old girl was admitted to the University of Virginia Hospital with a five-week history of fever, malaise, sore throat, and painless, cervical lymphadenopathy. Her medical history was unremarkable except for a References 1. Cantrell RW, Jensen JH, Reid D: Diagnosis and management of tuberculous cervical adenitis . Arch Otolaryngol 101:53-57, 1975.Crossref 2. Prissick FH, Masson AM: Cervical lymphadenitis in children caused by chromogenic mycobacteria . Can Med Assoc J 75:798-803, 1956. 3. MacKellar A: Diagnosis and management of atypical mycobacterial lymphadenitis in children . J Pediatr Surg 11:85-89, 1976.Crossref 4. Lee KJ, Fidler W, Kelly J, et al: Retropharyngeal swelling of unexpected etiologies . Conn Med 38:452-457, 1974. 5. Neumann JL, Schlueter DP: Retropharyngeal abscess as the presenting feature of tuberculosis of the cervical spine . Am Rev Respir Dis 110:508-511, 1974. 6. Lincoln EM, Gilbert LA: Disease in children due to mycobacteria other than Mycobacterium tuberculosis . Am Rev Respir Dis 105:683-714, 1972. 7. Barton LL, Feigin RD: Childhood cervical lymphadenitis: A reappraisal . J Pediatr 84:846-852, 1974.Crossref 8. Belin RP, Richardson JD, Richardson DL, et al: Diagnosis and management of scrofula in children . J Pediatr Surg 9:103-107, 1974.Crossref 9. Mandell F, Wright PF: Treatment of atypical mycobacterial cervical adenitis with rifampin . Pediatrics 55:39-43, 1975.

Journal

American Journal of Diseases of ChildrenAmerican Medical Association

Published: Feb 1, 1978

References